Handbook of Oncobiology

• Autore: Sobti R. C
• Pubblicazione: Singapore : , : Springer, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (1584 pages)
• Disciplina: 616.994
• Altri autori: GangulyNirmal K KumarRakesh
• Nota di contenuto: Intro -- Preface -- Acknowledgments -- Contents -- About the Editors -- About the Section Editors -- Contributors -- Part I: Understanding, Milestones, and Advancements in Cancer Biology -- 1 An Introduction to Recent Approaches Underlying Mechanistic Insights Harboring Oncobiology -- Introduction -- Factors Harboring Oncogenesis -- Cancer Staging and Diagnosis -- Carcinogens and Carcinogenesis -- Genomics Genetic Instability and DNA Mutations -- Intriguing Avenues Within the Realm of Oncobiology -- Telomerase -- TGF-β -- E-cadherin -- Protein Kinase, Cell Cycle Alterations -- p53 -- miRNA in Cancer -- Epigenetic Alterations -- Modified Angiogenesis and Metastasis -- Warburg Metabolism -- Treatment Protocols -- Immune Evasion and Immunotherapy -- Potential Future Trajectories in Oncobiology -- New and Emerging Technologies -- Immunogenomics and Immunotherapy -- Personalized Medicine (Precision Oncology and Its Significance) -- Artificial Intelligence in Oncology -- Stem Cell Therapy and Development of Vaccines -- Epigenetic Alterations and Tumor Microenvironment -- Metabolomics -- Gut Microbiota -- Nanotechnology -- Conclusion -- References -- 2 Types of Cancers, Epidemiology, and Molecular Insights -- Introduction -- Differences Between Normal Cells and Cancer Cells -- Common and Rare Cancers -- Breast Cancer -- Lung Cancer -- Colorectal Cancer -- Prostate Cancer -- Skin Cancer -- Leukemia -- Lymphoma -- Ovarian Cancer -- Pancreatic Cancer -- Bladder Cancer -- Rare Cancers -- Esophageal Cancer -- Chronic Myeloid Leukemia (Also Called as Chronic Myelogenous Leukemia) (CML) -- Childhood Acute Lymphoblastic Leukemia -- Anal Cancer -- Merkel Cell Carcinoma -- Thymic Carcinoma -- Hepatoblastoma -- Glioblastoma -- Ewing Sarcoma -- Kaposi Sarcoma -- Characteristics of Cancer -- Ability for Self-Sufficiency in Growth Signals -- Evading Apoptosis. ; Insensitivity to Anti-Growth Signals -- Sustained Angiogenesis -- Tissue Invasion and Metastasis -- Limitless Replication Potentials -- Reprogramming of Energy Metabolism -- Evasion of the Immune System -- Genome Instability -- Tumor-Promoting Inflammation -- Epidemiological and Etiological Advances in Understanding Cancers -- Oncogenes and Cancer Formation -- Etiological Factors in Cancer -- Understanding Cancer Etiology -- Age -- Child and Teen Cancer Incidence -- Infancy´s Impact -- Sexual Transmission -- Hormones -- Modifiable Risk Factors -- Sex -- Dietary Habits -- Socioeconomic Status -- Obesity -- Hygiene -- Microorganisms -- Tumorigenesis -- Cancer Genomics -- Epigenetics of Cancer -- Cancer Stem Cells -- Concluding Remarks -- References -- 3 Current Concepts and Advances in Oncobiology -- Introduction -- Viruses and Cancers -- Small DNA Tumor Viruses -- The Papillomavirus -- Merkel Cell Polyomavirus -- Polyomaviruses, SV40, and Adenoviruses -- Herpesviruses -- Hepatitis B Virus (HBV) -- RNA Oncoviruses -- Hepatitis C Virus (HCV) -- Retroviruses -- Human T-Lymphotropic Virus-1 (HTLV-1) -- Human Immunodeficiency Virus (HIV) -- Micro RNAs as Carcinogens -- Viral Molecule Diagnostic Efficacy in Cancer -- Hepatitis B Virus, Hepatitis C Virus: Hepatocellular Carcinoma -- Advances in Cancer -- Cancer Genetics -- Oncogenes -- Concluding Remarks -- References -- 4 Technological Advancements in Cancer Diagnosis and Prognosis -- Introduction -- Recent Advances in Cancer Diagnosis -- Fluid Biopsy -- Molecular Profiling -- Next-Generation Sequencing -- Role of MRI in Cancer Diagnosis -- Electrochemiluminescence (ECL) Nanosensing Systems -- Aptasensors -- M2 Pyruvate Kinase -- Staging and Grading of Cancers -- Classification of the TNM Staging System -- Staging Systems Other than the TNM System -- Ann Arbor´s Staging System -- FIGO Staging System. ; Importance of Cancer Staging (Cancer Staging Systems | ACS, n.d.) -- Classification of Cancer Grading -- Recent Developments in Prognosis -- MicroRNA as New Prognostic/Diagnostic Markers for Cancer -- Concluding Remarks -- References -- 5 Advanced Therapeutic Approaches in Cancer Therapy -- Introduction -- Precision Oncology -- Precision Surgery -- Recent Developments in Cancer Treatment -- Immunotherapy -- Immunomodulators -- Adoptive Cell Therapy -- CAR Constructs Can Be Divided into Five Generations -- Monoclonal Antibodies -- Dabrafenib-Trametinib -- Alfa-interferon Therapy -- Cancer Vaccines -- CRIPR/Cas9 -- DNA Cages -- HIPEC -- Hormone Therapy -- Nano Oncology -- Radiotherapy -- Oncolytic Virus Therapy -- Artificial Intelligence and Virtual Reality in Cancer Research -- Precision Oncology -- Precision Surgery -- Concluding Remarks -- References -- 6 History, Evolution, and Milestones in Cancer Research and Treatment -- Historical Aspects of Cancer Research and Treatment -- Oldest Descriptions of Cancer -- History of Cancer Research -- Cancer Chemotherapy -- Cancer Prevention with Vaccines -- Evolution of Cancer Research and Treatment -- Milestones in Cancer Research and Treatment -- Chemoprevention -- Nutrient-Related Agents -- Phyto Molecules -- Carotenoids -- Secondary Metabolites -- Molecularly Targeted Agents -- Hormonal Prevention -- Finasteride -- Tumor Microenvironment -- Biologic Transduction Pathways -- Peptide Drug -- Bacillus Calmette-Guérin (BCG) -- Hepatitis B -- Human Papillomavirus -- Oral Contraceptives -- The Major Advancement in Cancer Research and Treatment -- Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) -- Artificial Intelligence (AI) -- Robotic Surgery -- Telemedicine and Telehealth -- Infinium Assay -- Cryo-Electron Microscopy (Cryo-EM) -- Conclusion -- References. ; 7 Cancer Statistics: Geographical and Racial Disparities -- Introduction -- Statistics of Different Types of Cancers in the World -- Statistics of Different Types of Cancers in India -- Statistics of Cancer in Different Racial Groups -- References -- 8 A Comprehensive Overview of Various Cancer Types and Their Progression -- Introduction -- Breast Cancer -- Gene Involved in Aggressive Breast Cancer Progression -- STAT Influence on the TNBC -- Ovarian Cancer -- Lung Cancer -- Non-Small Cell Lung Cancer Signaling Pathway -- PI3K/AKT/mTOR Signaling Pathway -- Pancreatic Cancer -- K-Ras Oncogenic Signaling Pathway -- Wnt/β-Catenin Signaling Pathway -- Childhood Cancer -- Colorectal Cancer -- Wnt-β-Catenine Pathway -- PI3K/Akt/mTOR Signaling Pathways -- Renal Cancer -- PI3K/AKT/mTOR Pathway -- Wnt/β-Catenin Signaling -- Prostate Cancer -- Wnt/β-Catenin Signaling -- PI3-AKT Signaling Pathway -- Conclusion -- References -- 9 Strategies of Early Diagnosis of Cancers -- Introduction -- Characteristics of Cancer -- Progressive Proliferating Signaling -- Inhibiting Apoptosis -- Eluding Growth Inhibitors -- Cancer Screening and Different Markers for Early Cancer Detection -- Early Diagnostic -- Screening -- Constraints of Screening -- Biomarkers -- DNA Methylation -- Blood Biomarkers -- Tumor Biomarkers -- P53 Biomarker -- Scanning and Imaging Tests for Diagnosis of Cancer -- Pap Smear and Human Papillomavirus Testing -- Types of Scanning and Imaging Techniques Used for Diagnosis of Cancer -- X-Ray -- Computed Tomography (CT) -- Mammogram -- Ultrasound -- Magnetic Resonance Imaging (MRI) -- Nuclear Medicine Scan -- PET (Positron Emission Tomography) Scan -- Bone Scans -- MUGA Scans -- Conclusion -- References -- 10 Advancement in Cancer Modeling System: Latest Developments and Trends in Cancer Research and Healthcare Interventions -- Introduction. ; Historical Aspect of the Cancer Model System: Where It Started? -- What Method Should Be Used to Construct the Cancer Models? -- Conceptual Models -- Agent-Based Models, or ABMs -- Deterministic Models -- Machine Learning (ML) -- What Models Can Address? -- Tumor Growth Models -- Drug Dynamics and PKPD Models (Intra-Tumoral Biodistribution) -- Modeling Tumor Heterogeneity -- Tumor Microenvironment and Immune Interactions -- Examples of Specific Modeling Strategies -- Predator-Prey Models -- Evolutionary Game Theory -- Dynamic Precision Medicine -- An Insight into Cancer Model System -- In Vitro Models -- Cell Lines -- Emerging Trends in in Vitro Research -- Vascularization -- Organs on Chip -- Organoids -- In Vivo Models -- Patient-Derived Xenograft -- Genetically Engineered Mouse Models (GEMMs) -- Drosophila Melanogaster -- Pig Cancer Model -- Zebrafish -- Computational Models -- Conclusion -- References -- 11 Point of Care Molecular Diagnostics in Cancer -- Introduction -- Limitations of PoCs -- References -- 12 Genetics of Cancer: Past, Present, and Future -- Introduction -- Cancer Genetics in Past -- Present -- Future Perspectives in Cancer Genetics -- References -- 13 Mechanisms of Oncogenesis -- References -- 14 Recent Developments in Cancer Detection and Treatment -- Introduction -- Recent Advancements in Cancer Detection -- Recent Advancements in Cancer Treatments -- Conclusion -- References -- 15 Circadian Rhythms and Their Association with Cancer Development -- Introduction -- Circadian Clock Genes -- Circadian Clock and Cancer -- Core Circadian Genes and Hallmarks of Cancer -- Cell Proliferation -- Cancer Cell Signaling -- Apoptosis -- Cancer Cell Metabolism -- DNA Damage -- Conclusion -- References -- 16 Advances in Cancer Pain Management -- Introduction -- Pain Definitions -- Pain Classification and Pathophysiology -- Nociceptive Pain. ; Neuropathic Pain.
• Titolo autorizzato: Handbook of Oncobiology
• ISBN: 981-9962-63-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910861093203321
• Lo trovi qui: Univ. Federico II