Cancer biology review : a case-based approach / / editor, Walter M. Stadler

• Pubblicazione: New York, : Demos Medical Publishing, LLC, 2014
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (208 p.)
• Disciplina: 362.19699/40072
• Soggetto topico: Cancer - Genetic aspects; Cancer - Research
• Altri autori: StadlerWalter Michael
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; Title; Copyright; Contents; Contributors; Preface; 1. DNA Synthesis and Repair; A. Fundamentals of DNA Synthesis; Manish Sharma and Blase Polite; Overview; Clinical Translation: Mechanism of Action for Nucleotide Analog Agents and Antifolates; Clinical Translation: Mechanism of Action for Topoisomerase-Interacting Agents; Key Concepts; References; B. Fundamentals of DNA Damage and Repair; Philip Connell and Rita Nanda; Overview; Clinical Translation: Mechanism of Action for Radiotherapy; Clinical Translation: Mechanism of Action for Platinum Analogs ; Clinical Translation: BRCA1/2: Cancer Predisposition and Interaction With PARP InhibitorsClinical Translation: Hereditary Nonpolyposis Colorectal Cancer Predisposition Syndromes; Key Concepts; References; C. DNA Mutations and Alterations: Applications to Cancer Therapy; Amy L. Kaufman and Peter H. O'Donnell; Overview; Clinical Translation: Irinotecan; Clinical Translation: 6-Mercaptopurine; Key Concepts; References; 2. RNA Transcription and Translation; A. Fundamentals of RNA Transcription and Translation; Overview; Clinical Translation: Transcriptional Profiling in Cancer; Key Concepts ; ReferencesBibliography; B. microRNAs; Overview; Clinical Translation: microRNAs Diagnostics; Key Concepts; References; Bibliography; 3. Chromosomal Dynamics and Stability; A. Fundamentals of Chromosomal Organization and Epigenetic Modification; Christopher J. Mariani, Erika L. Moen, Kelly R. Ostler, and Lucy A. Godley; Overview; Clinical Translation: Mechanism of Action for Histone Deacetylase Inhibitors; Clinical Translation: Mechanism of Action of Hypomethylating Agents; Key Concepts; References; B. Fundamentals of Chromosome Structure and Segregation ; Christopher J. Mariani, Trisha Macrae, Michael Daunov, and Lucy A. GodleyOverview; Clinical Translation: Cancer Associated Chromosomal Translocations as Diagnostic Markers; Clinical Translation: Mechanism of Tubule Inhibitors; Key Concepts; References; 4. Cell Surface Receptors and Signal Transduction; A. Fundamentals of Growth Factor Receptor Tyrosine Kinase Signaling; Overview; Clinical Translation: Mechanism of Action of EGFR/HER2 and MET Inhibitors; Key Concepts; References; B. Fundamentals of Signal Transduction; Overview ; Clinical Translation: Clinical Implications for RAF and RAS MutationsClinical Translation: Mechanism of Action for PI3K and AKT Pathway Inhibitors; Clinical Translation: Mechanism of Action of IL6/JAK/STAT Inhibitors; Key Concepts; References; 5. Nuclear Hormone Receptors; A. Overview of Nuclear Hormone Receptors in Malignancy; Russell Z. Szmulewitz; References; B. Androgen Receptor and Estrogen Receptor; Russell Z. Szmulewitz and James E. Ward; Overview; Clinical Translation: Mechanism of Estrogen Receptor (ER) Antagonism in Breast Cancer ; Clinical Translation: Modulation of the AR Axis in Prostate Cancer
• Sommario/riassunto: Utilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter to
• Titolo autorizzato: Cancer biology review
• ISBN: 1-61705-140-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910828661303321
• Lo trovi qui: Univ. Federico II