LEADER 05171nam 2200625Ia 450 001 9910828661303321 005 20240314025200.0 010 $a1-61705-140-3 035 $a(CKB)2670000000402555 035 $a(EBL)1336608 035 $a(OCoLC)855505060 035 $a(SSID)ssj0000949818 035 $a(PQKBManifestationID)12412553 035 $a(PQKBTitleCode)TC0000949818 035 $a(PQKBWorkID)11003400 035 $a(PQKB)11703070 035 $a(MiAaPQ)EBC1336608 035 $a(Au-PeEL)EBL1336608 035 $a(CaPaEBR)ebr10742089 035 $a(CaONFJC)MIL539920 035 $a(OCoLC)857064804 035 $a(EXLCZ)992670000000402555 100 $a20130520d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCancer biology review $ea case-based approach /$feditor, Walter M. Stadler 205 $a1st ed. 210 $aNew York $cDemos Medical Publishing, LLC$d2014 215 $a1 online resource (208 p.) 300 $aDescription based upon print version of record. 311 $a1-936287-85-4 320 $aIncludes bibliographical references and index. 327 $aCover; Title; Copyright; Contents; Contributors; Preface; 1. DNA Synthesis and Repair; A. Fundamentals of DNA Synthesis; Manish Sharma and Blase Polite; Overview; Clinical Translation: Mechanism of Action for Nucleotide Analog Agents and Antifolates; Clinical Translation: Mechanism of Action for Topoisomerase-Interacting Agents; Key Concepts; References; B. Fundamentals of DNA Damage and Repair; Philip Connell and Rita Nanda; Overview; Clinical Translation: Mechanism of Action for Radiotherapy; Clinical Translation: Mechanism of Action for Platinum Analogs 327 $aClinical Translation: BRCA1/2: Cancer Predisposition and Interaction With PARP InhibitorsClinical Translation: Hereditary Nonpolyposis Colorectal Cancer Predisposition Syndromes; Key Concepts; References; C. DNA Mutations and Alterations: Applications to Cancer Therapy; Amy L. Kaufman and Peter H. O'Donnell; Overview; Clinical Translation: Irinotecan; Clinical Translation: 6-Mercaptopurine; Key Concepts; References; 2. RNA Transcription and Translation; A. Fundamentals of RNA Transcription and Translation; Overview; Clinical Translation: Transcriptional Profiling in Cancer; Key Concepts 327 $aReferencesBibliography; B. microRNAs; Overview; Clinical Translation: microRNAs Diagnostics; Key Concepts; References; Bibliography; 3. Chromosomal Dynamics and Stability; A. Fundamentals of Chromosomal Organization and Epigenetic Modification; Christopher J. Mariani, Erika L. Moen, Kelly R. Ostler, and Lucy A. Godley; Overview; Clinical Translation: Mechanism of Action for Histone Deacetylase Inhibitors; Clinical Translation: Mechanism of Action of Hypomethylating Agents; Key Concepts; References; B. Fundamentals of Chromosome Structure and Segregation 327 $aChristopher J. Mariani, Trisha Macrae, Michael Daunov, and Lucy A. GodleyOverview; Clinical Translation: Cancer Associated Chromosomal Translocations as Diagnostic Markers; Clinical Translation: Mechanism of Tubule Inhibitors; Key Concepts; References; 4. Cell Surface Receptors and Signal Transduction; A. Fundamentals of Growth Factor Receptor Tyrosine Kinase Signaling; Overview; Clinical Translation: Mechanism of Action of EGFR/HER2 and MET Inhibitors; Key Concepts; References; B. Fundamentals of Signal Transduction; Overview 327 $aClinical Translation: Clinical Implications for RAF and RAS MutationsClinical Translation: Mechanism of Action for PI3K and AKT Pathway Inhibitors; Clinical Translation: Mechanism of Action of IL6/JAK/STAT Inhibitors; Key Concepts; References; 5. Nuclear Hormone Receptors; A. Overview of Nuclear Hormone Receptors in Malignancy; Russell Z. Szmulewitz; References; B. Androgen Receptor and Estrogen Receptor; Russell Z. Szmulewitz and James E. Ward; Overview; Clinical Translation: Mechanism of Estrogen Receptor (ER) Antagonism in Breast Cancer 327 $aClinical Translation: Modulation of the AR Axis in Prostate Cancer 330 $aUtilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter to 606 $aCancer$xGenetic aspects$vCase studies 606 $aCancer$xResearch 615 0$aCancer$xGenetic aspects 615 0$aCancer$xResearch. 676 $a362.19699/40072 701 $aStadler$b Walter Michael$01681963 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910828661303321 996 $aCancer biology review$94117404 997 $aUNINA