Autoimmune neurology / / volume editors, Sean J. Pittock and Angela Vincent ; designer, Alan Studholme

• Pubblicazione: Amsterdam, [Netherlands] : , : Elsevier, , 2016; ©2016
• Descrizione fisica: 1 online resource (569 p.)
• Disciplina: 616.978
• Soggetto topico: Autoimmune diseases; Neurology; Autoimmune Diseases of the Nervous System - immunology
• Persona (resp. second.): PittockSean J.; VincentAngela; StudholmeAlan
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Front Cover; Autoimmune Neurology; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Introduction; Chapter 1: Introduction to Autoimmune Neurology; Autoimmune Neurology: A New Subspecialty; Neural Antibodies Resulting From the Body's Immune Response To cancer; Some Autoantibodies Targeting Intracellular Antigens are Not Closely Linked to Tumors; Pathogenic Autoantibodies; New Associations and Challenges; Which Drug, How Much, and for How long?; Understanding Immunopathogenesis will Lead to New Therapies ; Toward a Molecularly Defined ClassificationMeasuring and Interpreting Antibodies: Predicting Outcome and Guiding Therapeutic Decision Making; How Do Autoimmune Neurologic Disorders Arise? What is the Trigger? What Role Do Genetic and Environmental Factors play?...; Why are Specific Regions of the Nervous System Targeted, When the Autoantigen is Widely Expressed? What are the Factors That D.; Conclusion; Acknowledgments; References; Section 2: Basic neurobiology; Chapter 2: Signaling Molecules of the CNS as Targets of Autoimmunity; Basic Principles of Neuronal Signaling ; Basic Principles of ElectrophysiologyGeneral Features of Ion Channels; Classic Neurotransmission Vs Neuromodulation; Ion Channels and Shaping of Electrophysiologic Behavior of Neurons; Voltage-gated Sodium (Nav) Channels; Structure and Classification; Function; Voltage-gated Calcium Channels (Cav); Structure and Classification; Function; Voltage-gated K+ Channels (Kv); Structure and Classification; Function; Kv1 Channels; Kv2 Channels; Kv3 Channels; Kv4 Channels; Kv7 (Kcnq) Channels; Other K+ Channels; Calcium-activated K+ Channels (Kca); Inward Rectifying K+ Channels ; The two-pore Channels (K2P)Hyperpolarization-gated, Cyclic nucleotide-regulated Channels; Excitatory Neurotransmission; Anatomy and Neurochemistry of the Glutamatergic System; Glutamatergic Pathways in the Central Nervous System; Biosynthesis, Storage, and Release of L-glutamate; Ionotropic Glutamate Receptors; AMPA Receptors; Structure and Dynamics; Function; NMDA Receptors; Structure; Activation and Allosteric Modulation; Functions; Synaptic Vs Extrasynaptic NMDA Receptors; Metabotropic Glutamate Receptors; Group I mGluRs; Distribution and Transduction Mechanisms; Effects ; Group II and III MGluRsDistribution and Transduction Mechanisms; Effects; Inhibitory Neurotransmission; GABAergic System; Anatomic Distribution of GABAergic Neurons; Biosynthesis, Storage, Release, Uptake, and Metabolism of GABA; GABAA Receptors; Structure and Dynamics; Effects; Phasic and Tonic Gabaergic Inhibition; Modulation of GABAA Receptors; GABAB Receptors; Structure and Distribution; Effects; Glycine as a Neurotransmitter; Synthesis, Uptake, and Metabolism; Glycine Receptors; Structure and Distribution; Synaptic Effects; Glycine and GABA as Inhibitory Cotransmitters ; Clinical Correlations
• Sommario/riassunto: "Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders"--Publisher's description.
• Titolo autorizzato: Autoimmune neurology
• ISBN: 0-444-63446-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910583041503321
• Lo trovi qui: Univ. Federico II
• Serie: Handbook of Clinical Neurology