05871nam 2200673 450 991058304150332120201211195543.00-444-63446-0(CKB)3710000000614737(EBL)4451480(SSID)ssj0001674789(PQKBManifestationID)16477680(PQKBTitleCode)TC0001674789(PQKBWorkID)15017165(PQKB)10179534(MiAaPQ)EBC4451480(PPN)195538471(EXLCZ)99371000000061473720160328h20162016 uy 0engur|n|---|||||txtccrAutoimmune neurology /volume editors, Sean J. Pittock and Angela Vincent ; designer, Alan StudholmeAmsterdam, [Netherlands] :Elsevier,2016.©20161 online resource (569 p.)Handbook of Clinical Neurology. 3rd Series ;Volume 133Description based upon print version of record.0-444-63432-0 Includes bibliographical references at the end of each chapters and index.Front Cover; Autoimmune Neurology; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Introduction; Chapter 1: Introduction to Autoimmune Neurology; Autoimmune Neurology: A New Subspecialty; Neural Antibodies Resulting From the Body's Immune Response To cancer; Some Autoantibodies Targeting Intracellular Antigens are Not Closely Linked to Tumors; Pathogenic Autoantibodies; New Associations and Challenges; Which Drug, How Much, and for How long?; Understanding Immunopathogenesis will Lead to New TherapiesToward a Molecularly Defined ClassificationMeasuring and Interpreting Antibodies: Predicting Outcome and Guiding Therapeutic Decision Making; How Do Autoimmune Neurologic Disorders Arise? What is the Trigger? What Role Do Genetic and Environmental Factors play?...; Why are Specific Regions of the Nervous System Targeted, When the Autoantigen is Widely Expressed? What are the Factors That D.; Conclusion; Acknowledgments; References; Section 2: Basic neurobiology; Chapter 2: Signaling Molecules of the CNS as Targets of Autoimmunity; Basic Principles of Neuronal SignalingBasic Principles of ElectrophysiologyGeneral Features of Ion Channels; Classic Neurotransmission Vs Neuromodulation; Ion Channels and Shaping of Electrophysiologic Behavior of Neurons; Voltage-gated Sodium (Nav) Channels; Structure and Classification; Function; Voltage-gated Calcium Channels (Cav); Structure and Classification; Function; Voltage-gated K+ Channels (Kv); Structure and Classification; Function; Kv1 Channels; Kv2 Channels; Kv3 Channels; Kv4 Channels; Kv7 (Kcnq) Channels; Other K+ Channels; Calcium-activated K+ Channels (Kca); Inward Rectifying K+ ChannelsThe two-pore Channels (K2P)Hyperpolarization-gated, Cyclic nucleotide-regulated Channels; Excitatory Neurotransmission; Anatomy and Neurochemistry of the Glutamatergic System; Glutamatergic Pathways in the Central Nervous System; Biosynthesis, Storage, and Release of L-glutamate; Ionotropic Glutamate Receptors; AMPA Receptors; Structure and Dynamics; Function; NMDA Receptors; Structure; Activation and Allosteric Modulation; Functions; Synaptic Vs Extrasynaptic NMDA Receptors; Metabotropic Glutamate Receptors; Group I mGluRs; Distribution and Transduction Mechanisms; EffectsGroup II and III MGluRsDistribution and Transduction Mechanisms; Effects; Inhibitory Neurotransmission; GABAergic System; Anatomic Distribution of GABAergic Neurons; Biosynthesis, Storage, Release, Uptake, and Metabolism of GABA; GABAA Receptors; Structure and Dynamics; Effects; Phasic and Tonic Gabaergic Inhibition; Modulation of GABAA Receptors; GABAB Receptors; Structure and Distribution; Effects; Glycine as a Neurotransmitter; Synthesis, Uptake, and Metabolism; Glycine Receptors; Structure and Distribution; Synaptic Effects; Glycine and GABA as Inhibitory CotransmittersClinical Correlations"Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders"--Publisher's description.Handbook of Clinical NeurologyAutoimmune diseasesNeurologyAutoimmune Diseases of the Nervous SystemimmunologyAutoimmune Diseases of the Nervous SystemimmunologyAutoimmune diseases.Neurology.Autoimmune Diseases of the Nervous Systemimmunology.Autoimmune Diseases of the Nervous Systemimmunology.616.978Pittock Sean J.Vincent AngelaStudholme AlanMiAaPQMiAaPQMiAaPQBOOK9910583041503321Autoimmune neurology1922044UNINA