The OMICs : applications in neuroscience / / edited by Giovanni Coppola

• Pubblicazione: Oxford, England : , : Oxford University Press, , 2014; ©2014
• Descrizione fisica: 1 online resource (385 p.)
• Disciplina: 612.8/2
• Soggetto topico: Brain - Physiology; Genomics
• Soggetto genere / forma: Electronic books.
• Altri autori: CoppolaGiovanni
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Cover; THE OMICs; Copyright; CONTENTS; CONTRIBUTORS; PART ONE: DNA; 1. Medical DNA Sequencing in Neuroscience; 2 . Epigenomics: An Overview; 3. The Role of Epigenomics in Genetically Identical Individuals; PART TWO: RNA; 4. Transcriptomics; 5. Decoding Alternative mRNAs in the "Omics" Age; 6. Transcriptomics: From Differential Expression to Coexpression; 7. High-Throughput RNA Interference as a Tool for Discovery in Neuroscience; 8. The Genetics of Gene Expression: Multiple Layers and Multiple Players; PART THREE: PROTEIN; 9. Proteomics ; 10. Focused Plasma Proteomics for the Study of Brain Aging and NeurodegenerationPART FOUR: CELLS AND CONNECTIONS; 11. Cellomics: Characterization of Neural Subtypes by High-Throughput Methods and Transgenic Mouse Models; 12. Neuroscience and Metabolomics; 13. Brain Connectomics in Man and Mouse; 14. Optogenetics; 15. Characterizing the Gut Microbiome: Role in Brain-Gut Function; PART FIVE: THERAPEUTICS; 16. OMICs in Drug Discovery: From Small Molecule Leads to Clinical Candidates; 17. Pharmacogenomics; PART SIX: OMICsOME: INTEGRATION OF OMICs DATA ; 18. Multidimensional Databases of Model Organisms19. Network Biology and Molecular Medicine in the Postgenomic Era: The Systems Pathobiology of Network Medicine; Links to Helpful Resources; Index
• Sommario/riassunto: The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications
• Titolo autorizzato: The OMICs
• ISBN: 0-19-938980-2; 0-19-935499-5
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910463440103321
• Lo trovi qui: Univ. Federico II