Ubiquitin : Proteasome Pathway / / Xianquan Zhan, editor

• Pubblicazione: London : , : IntechOpen, , 2020
• Descrizione fisica: 1 online resource (xi, 95 pages)
• Disciplina: 612.82
• Soggetto topico: Ubiquitin
• Persona (resp. second.): ZhanXianquan
• Nota di bibliografia: Includes bibliographical references.
• Sommario/riassunto: The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.
• Altri titoli varianti: Ubiquitin
• Titolo autorizzato: Ubiquitin
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910688466803321
• Lo trovi qui: Univ. Federico II