01989nam 2200373 450 991068846680332120230623195621.0(CKB)5400000000040853(NjHacI)995400000000040853(EXLCZ)99540000000004085320230623d2020 uy 0engur|||||||||||txtrdacontentcrdamediacrrdacarrierUbiquitin Proteasome Pathway /Xianquan Zhan, editorLondon :IntechOpen,2020.1 online resource (xi, 95 pages)Biochemistry ;Volume 181-83880-842-6 Includes bibliographical references.The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.Ubiquitin UbiquitinUbiquitin.612.82Zhan XianquanNjHacINjHaclBOOK9910688466803321Ubiquitin2951478UNINA