| Autore |
Williams Gareth R.
|
| Pubbl/distr/stampa |
London, England : , : UCL Press, , 2018
|
| Descrizione fisica |
1 online resource (242 pages)
|
| Disciplina |
615.6
|
| Soggetto topico |
Drug delivery systems
|
| Formato |
Materiale a stampa  |
| Livello bibliografico |
Monografia |
| Lingua di pubblicazione |
eng
|
| Nota di contenuto |
Intro; Half Title; Title Page; Copyright Page; Acknowledgements; Contents; List of figures; List of abbreviations; 1 Introduction; 1.1 Preamble; 1.2 Nanofibres; 1.3 Key concepts in drug delivery; 1.3.1 The therapeutic window and bioavailability; 1.3.2 Modified-release systems; 1.3.3 Dissolution, solubility and permeability; 1.3.4 Physical form; 1.4 Nanofibre characterisation; 1.4.1 Electron microscopy; 1.4.2 X-ray diffraction; 1.4.3 Thermal methods; 1.4.4 Infrared spectroscopy; 1.4.5 Functional performance; 1.4.5.1 Dissolution and permeability testing; 1.4.5.2 API quantification 1.4.6 Stability studies1.5 An overview of contemporary pharmaceutical technology; 1.5.1 Hot melt extrusion; 1.5.2 Spray drying; 1.5.3 Freeze drying; 1.5.4 Nanofibre manufacturing; 1.6 Summary; References; 2 Electrospinning fundamentals; 2.1 Background; 2.2 A brief history of electrospinning; 2.3 EHD fundamentals; 2.4 Understanding the electrospinning process; 2.4.1 Jet initiation; 2.4.2 Electrospinning vs. electrospraying; 2.4.3 Jet elongation: bending and whipping; 2.4.4 Jet solidification; 2.5 The parameters affecting electrospinning; 2.5.1 Solution parameters; 2.5.2 Processing parameters 2.5.3 Environmental parameters2.5.4 Solvent and polymer selection; 2.6 The experimental set-up; 2.6.1 Basics; 2.6.2 The power supply and syringe pump; 2.6.3 The spinneret; 2.6.4 The collector; 2.6.5 Other considerations; 2.6.6 Establishing and troubleshooting an electrospinning process; 2.7 Fibre properties; 2.8 Characterisation; 2.9 Summary; References; 3 Monoaxial electrospinning; 3.1 Introduction; 3.2 Experimental considerations; 3.2.1 Solution parameters; 3.2.2 Processing parameters; 3.2.3 The spinneret; 3.2.4 Polymer choice; 3.2.5 Starting experimental work; 3.3 Fibre properties 3.4 Some typical results3.5 Fast-dissolving drug delivery systems; 3.5.1 Electrospun fast-dissolving drug delivery systems; 3.5.2 Caveats; 3.5.3 Multicomponent formulations; 3.5.4 Stability; 3.6 Extended-release systems; 3.6.1 Applications; 3.6.2 Drawbacks and release mechanisms; 3.7 pH-controlled delivery; 3.7.1 Oral administration; 3.7.2 Anticancer applications; 3.8 Pulsatile release; 3.9 Multilayer materials; 3.10 Thermoresponsive systems; 3.11 Emulsion and suspension electrospinning; 3.11.1 Emulsions; 3.11.2 Suspensions; 3.12 Tissue-engineering applications 3.13 Using fibres as sacrificial templates3.14 Conclusions; References; 4 Coaxial and multi-axial electrospinning; 4.1 Introduction; 4.2 Experimental considerations; 4.2.1 Handling two liquids; 4.2.2 The spinneret and electrodes; 4.2.3 Establishing a coaxial process; 4.3 Extended-release systems; 4.3.1 Preventing burst release; 4.3.2 Biphasic release; 4.4 Targeted drug delivery; 4.5 Multifunctional materials; 4.6 Other applications; 4.7 Protein delivery systems; 4.8 Cell electrospinning; 4.9 Modified coaxial spinning; 4.10 Triaxial and quad-axial systems; 4.11 Conclusions; References.
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| Record Nr. | UNINA-9910682516103321 |
Info
Nanofibres in Drug Delivery
