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ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910133588303321 |
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide
| ADMET for Medicinal Chemists [[electronic resource] ] : A Practical Guide |
| Autore | Tsaioun Katya |
| Pubbl/distr/stampa | Hoboken, : Wiley, 2012 |
| Descrizione fisica | 1 online resource (524 p.) |
| Disciplina |
615.19
615/.19 |
| Altri autori (Persone) | KatesSteven A |
| Soggetto topico |
Drug Design
Drug Toxicity Drugs - Testing Drugs --Testing --Juvenile literature Pharmaceutical Preparations - chemistry Pharmacokinetics Metabolic Phenomena Drug Discovery Pharmacological Phenomena Natural Science Disciplines Kinetics Chemicals and Drugs Poisoning Biochemical Phenomena Chemistry, Pharmaceutical Substance-Related Disorders Disciplines and Occupations Investigative Techniques Physiological Phenomena Phenomena and Processes Chemical Phenomena Diseases Pharmacology Analytical, Diagnostic and Therapeutic Techniques and Equipment Biological Science Disciplines Chemistry Pharmaceutical Preparations Health & Biological Sciences Pharmacy, Therapeutics, & Pharmacology |
| ISBN |
1-280-59122-6
9786613621054 0-470-91509-9 0-470-91511-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
ADMET for Medicinal Chemists: A Practical Guide; CONTENTS; Preface; Contributors; 1 Introduction; 1.1 Introduction; 1.2 Voyage Through The Digestive System; 1.2.1 The Mouth; 1.2.2 The Stomach; 1.2.3 The Small Intestine: Duodenum; 1.2.4 The Small and Large Intestine: Jejunum, Ileum, Colon; 1.2.5 Hepatic-Portal Vein; 1.3 The Liver Metabolism; 1.3.1 CYP450 (CYPs); 1.4 The Kidneys; 1.4.1 Active Tubular Secretion; 1.4.2 Passive Tubular Reabsorption; 1.5 Conclusions; References; 2 In Silico ADME/Tox Predictions; 2.1 Introduction; 2.2 Key Computer Methods for ADME/Tox Predictions
2.2.1 Drug Discovery2.2.2 Applying or Not ADME/Tox Predictions, Divided Opinions; 2.2.3 In Silico ADME/Tox Methods and Modeling Approaches; 2.2.4 Physicochemistry, Pharmacokinetics, Drug-Like and Lead-Like Concepts; 2.2.5 Lipophilicity; 2.2.6 pKa; 2.2.7 Transport Proteins; 2.2.8 Plasma Protein Binding; 2.2.9 Metabolism; 2.2.10 Elimination; 2.2.11 Toxicity; 2.3 Preparation of Compound Collections and Computer Programs, Challenging ADME/Tox Predictions and Statistical Methods; 2.3.1 Preparation of Compound Collections and Computer Programs 2.3.2 Preparing a Compound Collection: Materials and Methods2.3.3 Cleaning and Designing the Compound Collection; 2.3.4 Searching for Similarity; 2.3.5 Generating 3D Structures; 2.4 ADME/Tox Predictions within Pharmaceutics Companies; 2.4.1 Actelion Pharmaceuticals Ltd.; 2.4.2 Bayer; 2.4.3 Bristol-Myers Squibb; 2.4.4 Hoffmann-La Roche Ltd.; 2.4.5 Neurogen Corporation; 2.4.6 Novartis; 2.4.7 Schering AG; 2.4.8 Vertex Pharmaceuticals; 2.5 Challenging ADME/Tox Predictions; 2.5.1 Tolcapone; 2.5.2 Factor V Inhibitors; 2.5.3 CRF-1 Receptor Antagonists; 2.6 Statistical Methods 2.6.1 Principal Component Analysis2.6.2 Partial Least Square; 2.6.3 Support Vector Machine; 2.6.4 Decision Trees; 2.6.5 Neural Networks; 2.7 Conclusions; References; 3 Absorption and Physicochemical Properties of the NCE; 3.1. Introduction; 3.2. Physicochemical Properties; 3.3. Stability; 3.4. Dissolution and Solubility; 3.4.1. Dissolution Rate, Particle Size, and Solubility; 3.4.2. pH and Salts; 3.4.3. In Vivo Solubilization; 3.5. Solid State; References; 4 ADME; 4.1 Introduction; 4.2 Absorption; 4.2.1 Route of Administration; 4.2.2 Factors Determining Oral Bioavailability; 4.3 Distribution 4.3.1 Drug Distribution4.3.2 Volume of Distribution; 4.3.3 Free Drug Concentration; 4.3.4 CNS Penetration; 4.4 Elimination; 4.4.1 Elimination Versus Clearance; 4.4.2 Metabolism Versus Excretion; 4.4.3 Drug-Free Fraction and Clearance; 4.4.4 Lipophilicity and Clearance; 4.4.5 Transporters and Clearance; 4.4.6 Metabolism; 4.4.7 Excretion; 4.5 Drug Interactions; 4.5.1 Absorption-Driven DDI; 4.5.2 Distribution-Driven DDI; 4.5.3 Excretion-Driven DDI; 4.5.4 Metabolism-Driven DDI; 4.5.5 Tools for Studying Drug Metabolism; 4.5.6 Applications of Drug Metabolism Tools 4.5.7 Tools for Studying Drug Excretion |
| Record Nr. | UNINA-9910830164603321 |
|
Tsaioun Katya
|
||
| Hoboken, : Wiley, 2012 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Chemical kinetics and transport / Peter C. Jordan
| Chemical kinetics and transport / Peter C. Jordan |
| Autore | Jordan, Peter C. |
| Pubbl/distr/stampa | New York : Plenum Press, c1979 |
| Descrizione fisica | xvi, 368 p. : ill. ; 24 cm. |
| Soggetto topico |
Chemical kinetics
Chemistry, physical Kinetics Transport theory |
| Classificazione |
53.1.67
53.6 53.9.2 54 541'.39 QD501 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991000849129707536 |
|
Jordan, Peter C.
|
||
| New York : Plenum Press, c1979 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
Clinical pharmacokinetics
| Clinical pharmacokinetics |
| Pubbl/distr/stampa | [Langhorne, PA], : Adis International |
| Descrizione fisica | 1 online resource (volumes) |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Pharmacokinetics Kinetics Pharmacocinétique Pharmacologie pharmacology |
| Soggetto genere / forma |
Periodical
Periodicals. |
| Soggetto non controllato |
Pharmacology
Pharmacy |
| ISSN | 1179-1926 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-996202236403316 |
| [Langhorne, PA], : Adis International | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Clinical pharmacokinetics
| Clinical pharmacokinetics |
| Pubbl/distr/stampa | [Langhorne, PA], : Adis International |
| Descrizione fisica | 1 online resource (volumes) |
| Disciplina | 615 |
| Soggetto topico |
Pharmacology
Pharmacokinetics Kinetics pharmacology |
| Soggetto genere / forma |
Periodical
Periodicals |
| ISSN | 1179-1926 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910482002203321 |
| [Langhorne, PA], : Adis International | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Crystallization kinetics of calcium-magnesium aluminosilicate (CMAS) glass / / Valerie L. Wiesner and Narottam P. Bansal
| Crystallization kinetics of calcium-magnesium aluminosilicate (CMAS) glass / / Valerie L. Wiesner and Narottam P. Bansal |
| Autore | Wiesner Valerie L. |
| Pubbl/distr/stampa | Cleveland, Ohio : , : National Aeronautics and Space Administration, Glenn Research Center, , February 2015 |
| Descrizione fisica | 1 online resource (15 pages) : illustrations |
| Collana | NASA/TM |
| Soggetto topico |
Crystallization
Kinetics Calcium Magnesium Glass |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Crystallization kinetics of calcium-magnesium aluminosilicate |
| Record Nr. | UNINA-9910703782103321 |
|
Wiesner Valerie L.
|
||
| Cleveland, Ohio : , : National Aeronautics and Space Administration, Glenn Research Center, , February 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Engineering and programming manual [[electronic resource] ] : two-dimensional kinetic reference computer program (TDK) / / by G.R. Nickerson, L.D. Dang, D.E. Coats
| Engineering and programming manual [[electronic resource] ] : two-dimensional kinetic reference computer program (TDK) / / by G.R. Nickerson, L.D. Dang, D.E. Coats |
| Autore | Nickerson Gary R |
| Pubbl/distr/stampa | [Huntsville], Al. : , : National Aeronautics and Space Administration, George C. Marshall Space Flight Center, , [1985] |
| Descrizione fisica | 1 online resource (494 unnumbered pages) : illustrations |
| Altri autori (Persone) |
DangLahn D
CoatsD. E |
| Collana | NASA-CR |
| Soggetto topico |
Computer programs
Kinetics Liquid rocket propellants Performance prediction Thrust chambers User manuals (computer programs) Mechanics, Analytic Liquid propellants |
| Soggetto genere / forma | Computer programs. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Engineering and programming manual |
| Record Nr. | UNINA-9910701478903321 |
|
Nickerson Gary R
|
||
| [Huntsville], Al. : , : National Aeronautics and Space Administration, George C. Marshall Space Flight Center, , [1985] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enzyme kinetics (Michaelis-Menten) / / Gerald W. Feigenson
| Enzyme kinetics (Michaelis-Menten) / / Gerald W. Feigenson |
| Autore | Feigenson Gerald W. (Cornell University, USA) |
| Pubbl/distr/stampa | London, : Henry Stewart Talks, 2020 |
| Descrizione fisica | 1 online resource (1 streaming video file (41 min.) : color, sound) |
| Collana | Principles of biochemistry |
| Soggetto topico |
Biomathematics
Catalysis Enzyme kinetics Enzymes - Chemistry Enzymes - chemistry Enzymes - metabolism Kinetics Models, Chemical |
| Formato | Videoregistrazioni  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Contents: Initial reaction velocity -- Catalysed vs. uncatalysed reaction pathways -- Enzyme saturation/Maximum reaction velocity -- Michaelis-Menten equation -- Energy barriers and rate constants -- Measuring Km and Vmax -- The Lineweaver-Burk plot. |
| Record Nr. | UNINA-9910597099303321 |
|
Feigenson Gerald W. (Cornell University, USA)
|
||
| London, : Henry Stewart Talks, 2020 | ||
| Videoregistrazioni | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
European journal of drug metabolism and pharmacokinetics
| European journal of drug metabolism and pharmacokinetics |
| Pubbl/distr/stampa | [Paris], : [Edifor], [1976]- |
| Soggetto topico |
Drugs - Metabolism
Pharmacokinetics Médicaments - Métabolisme Pharmacocinétique Kinetics Pharmaceutical Preparations - metabolism Pharmacology |
| Soggetto genere / forma |
Periodicals.
Fulltext Internet Resources. Periodical |
| Soggetto non controllato | Titles of journals |
| ISSN | 2107-0180 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Drug metabolism and pharmacokinetics
Eur. j. drug metab. pharmacokinet |
| Record Nr. | UNISA-996214881303316 |
| [Paris], : [Edifor], [1976]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
European journal of drug metabolism and pharmacokinetics
| European journal of drug metabolism and pharmacokinetics |
| Pubbl/distr/stampa | [Paris], : [Edifor], [1976]- |
| Soggetto topico |
Drugs - Metabolism
Pharmacokinetics Kinetics Pharmaceutical Preparations - metabolism Pharmacology Médicaments - Métabolisme Pharmacocinétique Metabolisme dels medicaments Farmacocinètica |
| Soggetto genere / forma |
Periodical
Fulltext Internet Resources. Periodicals. Revistes electròniques. |
| ISSN | 2107-0180 |
| Formato | Materiale a stampa |
| Livello bibliografico | Periodico |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Drug metabolism and pharmacokinetics
Eur. j. drug metab. pharmacokinet |
| Record Nr. | UNINA-9910307947803321 |
| [Paris], : [Edifor], [1976]- | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
