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Applied mixed models in medicine / / Helen Brown, Robin Prescott
| Applied mixed models in medicine / / Helen Brown, Robin Prescott |
| Autore | Brown Helen <1962-> |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (539 p.) |
| Disciplina | 610.72/7 |
| Collana | Statistics in Practice |
| Soggetto topico | Medicine |
| ISBN |
1-118-77824-3
1-322-52060-7 1-118-77823-5 1-118-77821-9 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface to third edition; Mixed models notation; About the Companion Website; Chapter 1 Introduction; 1.1 The use of mixed models; 1.2 Introductory example; 1.2.1 Simple model to assess the effects of treatment (Model A); 1.2.2 A model taking patient effects into account (Model B); 1.2.3 Random effects model (Model C); 1.2.4 Estimation (or prediction) of random effects; 1.3 A multi-centre hypertension trial; 1.3.1 Modelling the data; 1.3.2 Including a baseline covariate (Model B); 1.3.3 Modelling centre effects (Model C)
1.3.4 Including centre-by-treatment interaction effects (Model D)1.3.5 Modelling centre and centre·treatment effects as random (Model E); 1.4 Repeated measures data; 1.4.1 Covariance pattern models; 1.4.2 Random coefficients models; 1.5 More about mixed models; 1.5.1 What is a mixed model?; 1.5.2 Why use mixed models?; 1.5.3 Communicating results; 1.5.4 Mixed models in medicine; 1.5.5 Mixed models in perspective; 1.6 Some useful definitions; 1.6.1 Containment; 1.6.2 Balance; 1.6.3 Error strata; Chapter 2 Normal mixed models; 2.1 Model definition; 2.1.1 The fixed effects model 2.1.2 The mixed model2.1.3 The random effects model covariance structure; 2.1.4 The random coefficients model covariance structure; 2.1.5 The covariance pattern model covariance structure; 2.2 Model fitting methods; 2.2.1 The likelihood function and approaches to its maximisation; 2.2.2 Estimation of fixed effects; 2.2.3 Estimation (or prediction) of random effects and coefficients; 2.2.4 Estimation of variance parameters; 2.3 The Bayesian approach; 2.3.1 Introduction; 2.3.2 Determining the posterior density; 2.3.3 Parameter estimation, probability intervals and p-values 2.3.4 Specifying non-informative prior distributions2.3.5 Evaluating the posterior distribution; 2.4 Practical application and interpretation; 2.4.1 Negative variance components; 2.4.2 Accuracy of variance parameters; 2.4.3 Bias in fixed and random effects standard errors; 2.4.4 Significance testing; 2.4.5 Confidence intervals; 2.4.6 Checking model assumptions; 2.4.7 Missing data; 2.4.8 Determining whether the simulated posterior distribution has converged; 2.5 Example; 2.5.1 Analysis models; 2.5.2 Results; 2.5.3 Discussion of points from Section 2.4; Chapter 3 Generalised linear mixed models 3.1 Generalised linear models3.1.1 Introduction; 3.1.2 Distributions; 3.1.3 The general form for exponential distributions; 3.1.4 The GLM definition; 3.1.5 Fitting the GLM; 3.1.6 Expressing individual distributions in the general exponential form; 3.1.7 Conditional logistic regression; 3.2 Generalised linear mixed models; 3.2.1 The GLMM definition; 3.2.2 The likelihood and quasi-likelihood functions; 3.2.3 Fitting the GLMM; 3.3 Practical application and interpretation; 3.3.1 Specifying binary data; 3.3.2 Uniform effects categories; 3.3.3 Negative variance components 3.3.4 Presentation of fixed and random effects estimates |
| Record Nr. | UNINA-9910132307003321 |
Brown Helen <1962->
|
||
| Chichester, England : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Applied mixed models in medicine / / Helen Brown, Robin Prescott
| Applied mixed models in medicine / / Helen Brown, Robin Prescott |
| Autore | Brown Helen <1962-> |
| Edizione | [Third edition.] |
| Pubbl/distr/stampa | Chichester, England : , : Wiley, , 2015 |
| Descrizione fisica | 1 online resource (539 p.) |
| Disciplina | 610.72/7 |
| Collana | Statistics in Practice |
| Soggetto topico | Medicine |
| ISBN |
1-118-77824-3
1-322-52060-7 1-118-77823-5 1-118-77821-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover; Title Page; Copyright; Contents; Preface to third edition; Mixed models notation; About the Companion Website; Chapter 1 Introduction; 1.1 The use of mixed models; 1.2 Introductory example; 1.2.1 Simple model to assess the effects of treatment (Model A); 1.2.2 A model taking patient effects into account (Model B); 1.2.3 Random effects model (Model C); 1.2.4 Estimation (or prediction) of random effects; 1.3 A multi-centre hypertension trial; 1.3.1 Modelling the data; 1.3.2 Including a baseline covariate (Model B); 1.3.3 Modelling centre effects (Model C)
1.3.4 Including centre-by-treatment interaction effects (Model D)1.3.5 Modelling centre and centre·treatment effects as random (Model E); 1.4 Repeated measures data; 1.4.1 Covariance pattern models; 1.4.2 Random coefficients models; 1.5 More about mixed models; 1.5.1 What is a mixed model?; 1.5.2 Why use mixed models?; 1.5.3 Communicating results; 1.5.4 Mixed models in medicine; 1.5.5 Mixed models in perspective; 1.6 Some useful definitions; 1.6.1 Containment; 1.6.2 Balance; 1.6.3 Error strata; Chapter 2 Normal mixed models; 2.1 Model definition; 2.1.1 The fixed effects model 2.1.2 The mixed model2.1.3 The random effects model covariance structure; 2.1.4 The random coefficients model covariance structure; 2.1.5 The covariance pattern model covariance structure; 2.2 Model fitting methods; 2.2.1 The likelihood function and approaches to its maximisation; 2.2.2 Estimation of fixed effects; 2.2.3 Estimation (or prediction) of random effects and coefficients; 2.2.4 Estimation of variance parameters; 2.3 The Bayesian approach; 2.3.1 Introduction; 2.3.2 Determining the posterior density; 2.3.3 Parameter estimation, probability intervals and p-values 2.3.4 Specifying non-informative prior distributions2.3.5 Evaluating the posterior distribution; 2.4 Practical application and interpretation; 2.4.1 Negative variance components; 2.4.2 Accuracy of variance parameters; 2.4.3 Bias in fixed and random effects standard errors; 2.4.4 Significance testing; 2.4.5 Confidence intervals; 2.4.6 Checking model assumptions; 2.4.7 Missing data; 2.4.8 Determining whether the simulated posterior distribution has converged; 2.5 Example; 2.5.1 Analysis models; 2.5.2 Results; 2.5.3 Discussion of points from Section 2.4; Chapter 3 Generalised linear mixed models 3.1 Generalised linear models3.1.1 Introduction; 3.1.2 Distributions; 3.1.3 The general form for exponential distributions; 3.1.4 The GLM definition; 3.1.5 Fitting the GLM; 3.1.6 Expressing individual distributions in the general exponential form; 3.1.7 Conditional logistic regression; 3.2 Generalised linear mixed models; 3.2.1 The GLMM definition; 3.2.2 The likelihood and quasi-likelihood functions; 3.2.3 Fitting the GLMM; 3.3 Practical application and interpretation; 3.3.1 Specifying binary data; 3.3.2 Uniform effects categories; 3.3.3 Negative variance components 3.3.4 Presentation of fixed and random effects estimates |
| Record Nr. | UNINA-9910810323603321 |
|
Brown Helen <1962->
|
||
| Chichester, England : , : Wiley, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biological and Medical Data Analysis [[electronic resource] ] : 5th International Symposium, ISBMDA 2004, Barcelona, Spain, November 18-19, 2004, Proceedings / / edited by José María Barreiro, Fernando Martin-Sanchez, Víctor Maojo, Ferran Sanz
| Biological and Medical Data Analysis [[electronic resource] ] : 5th International Symposium, ISBMDA 2004, Barcelona, Spain, November 18-19, 2004, Proceedings / / edited by José María Barreiro, Fernando Martin-Sanchez, Víctor Maojo, Ferran Sanz |
| Edizione | [1st ed. 2004.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004 |
| Descrizione fisica | 1 online resource (XII, 512 p.) |
| Disciplina | 610.72/7 |
| Collana | Lecture Notes in Computer Science |
| Soggetto topico |
Medicine
Database management Health informatics Mathematical statistics Information storage and retrieval Artificial intelligence Biomedicine, general Database Management Health Informatics Probability and Statistics in Computer Science Information Storage and Retrieval Artificial Intelligence |
| ISBN | 3-540-30547-5 |
| Classificazione |
42.11
44.32 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Data Analysis for Image Processing -- RF Inhomogeneity Correction Algorithm in Magnetic Resonance Imaging -- Fully 3D Wavelets MRI Compression -- A New Approach to Automatic Segmentation of Bone in Medical Magnetic Resonance Imaging -- An Accurate and Parallelizable Geometric Projector/Backprojector for 3D PET Image Reconstruction -- Data Visualization -- EEG Data and Data Analysis Visualization -- A Web Information System for Medical Image Management -- Reliable Space Leaping Using Distance Template -- Decision Support Systems -- A Rule-Based Knowledge System for Diagnosis of Mental Retardation -- Case-Based Diagnosis of Dysmorphic Syndromes -- Bayesian Prediction of Down Syndrome Based on Maternal Age and Four Serum Markers -- SOC: A Distributed Decision Support Architecture for Clinical Diagnosis -- Decision Support Server Architecture for Mobile Medical Applications -- Ordered Time-Independent CIG Learning -- SINCO: Intelligent System in Disease Prevention and Control. An Architectural Approach -- Could a Computer Based System for Evaluating Patients with Suspected Myocardial Infarction Improve Ambulance Allocation? -- On the Robustness of Feature Selection with Absent and Non-observed Features -- Design of a Neural Network Model as a Decision Making Aid in Renal Transplant -- Learning the Dose Adjustment for the Oral Anticoagulation Treatment -- Information Retrieval -- Thermal Medical Image Retrieval by Moment Invariants -- Knowledge Discovery and Data Mining -- Employing Maximum Mutual Information for Bayesian Classification -- Model Selection for Support Vector Classifiers via Genetic Algorithms. An Application to Medical Decision Support -- Selective Classifiers Can Be Too Restrictive: A Case-Study in Oesophageal Cancer -- A Performance Comparative Analysis Between Rule-Induction Algorithms and Clustering-Based Constructive Rule-Induction Algorithms. Application to Rheumatoid Arthritis -- Domain-Specific Particularities of Data Mining: Lessons Learned -- Statistical Methods and Tools for Biological and Medical Data Analysis -- A Structural Hierarchical Approach to Longitudinal Modeling of Effects of Air Pollution on Health Outcomes -- Replacing Indicator Variables by Fuzzy Membership Functions in Statistical Regression Models: Examples of Epidemiological Studies -- PCA Representation of ECG Signal as a Useful Tool for Detection of Premature Ventricular Beats in 3-Channel Holter Recording by Neural Network and Support Vector Machine Classifier -- Finding Relations in Medical Diagnoses and Procedures -- An Automatic Filtering Procedure for Processing Biomechanical Kinematic Signals -- Analysis of Cornea Transplant Tissue Rejection Delay in Mice Subjects -- Toward a Model of Clinical Trials -- Time Series Analysis -- Predicting Missing Parts in Time Series Using Uncertainty Theory -- Classification of Long-Term EEG Recordings -- Application of Quantitative Methods of Signal Processing to Automatic Classification of Long-Term EEG Records -- Semantic Reference Model in Medical Time Series -- Control of Artificial Hand via Recognition of EMG Signals -- Bioinformatics: Data Management and Analysis in Bioinformatics -- SEQPACKER: A Biologist-Friendly User Interface to Manipulate Nucleotide Sequences in Genomic Epidemiology -- Performing Ontology-Driven Gene Prediction Queries in a Multi-agent Environment -- Protein Folding in 2-Dimensional Lattices with Estimation of Distribution Algorithms -- Bioinformatics: Integration of Biological and Medical Data -- Quantitative Evaluation of Established Clustering Methods for Gene Expression Data -- DiseaseCard: A Web-Based Tool for the Collaborative Integration of Genetic and Medical Information -- Biomedical Informatics: From Past Experiences to the Infobiomed Network of Excellence -- Bioinformatics: Metabolic Data and Pathways -- Network Analysis of the Kinetics of Amino Acid Metabolism in a Liver Cell Bioreactor -- Model Selection and Adaptation for Biochemical Pathways -- NeoScreen: A Software Application for MS/MS Newborn Screening Analysis -- Bioinformatics: Microarray Data Analysis and Visualization -- Technological Platform to Aid the Exchange of Information and Applications Using Web Services -- Visualization of Biological Information with Circular Drawings -- Gene Selection Using Genetic Algorithms -- Knowledgeable Clustering of Microarray Data -- Correlation of Expression Between Different IMAGE Clones from the Same UniGene Cluster. |
| Record Nr. | UNISA-996466364903316 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Biological and Medical Data Analysis : 5th International Symposium, ISBMDA 2004, Barcelona, Spain, November 18-19, 2004, Proceedings / / edited by José María Barreiro, Fernando Martin-Sanchez, Víctor Maojo, Ferran Sanz
| Biological and Medical Data Analysis : 5th International Symposium, ISBMDA 2004, Barcelona, Spain, November 18-19, 2004, Proceedings / / edited by José María Barreiro, Fernando Martin-Sanchez, Víctor Maojo, Ferran Sanz |
| Edizione | [1st ed. 2004.] |
| Pubbl/distr/stampa | Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004 |
| Descrizione fisica | 1 online resource (XII, 512 p.) |
| Disciplina | 610.72/7 |
| Collana | Lecture Notes in Computer Science |
| Soggetto topico |
Medicine
Database management Health informatics Mathematical statistics Information storage and retrieval Artificial intelligence Biomedicine, general Database Management Health Informatics Probability and Statistics in Computer Science Information Storage and Retrieval Artificial Intelligence |
| ISBN | 3-540-30547-5 |
| Classificazione |
42.11
44.32 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Data Analysis for Image Processing -- RF Inhomogeneity Correction Algorithm in Magnetic Resonance Imaging -- Fully 3D Wavelets MRI Compression -- A New Approach to Automatic Segmentation of Bone in Medical Magnetic Resonance Imaging -- An Accurate and Parallelizable Geometric Projector/Backprojector for 3D PET Image Reconstruction -- Data Visualization -- EEG Data and Data Analysis Visualization -- A Web Information System for Medical Image Management -- Reliable Space Leaping Using Distance Template -- Decision Support Systems -- A Rule-Based Knowledge System for Diagnosis of Mental Retardation -- Case-Based Diagnosis of Dysmorphic Syndromes -- Bayesian Prediction of Down Syndrome Based on Maternal Age and Four Serum Markers -- SOC: A Distributed Decision Support Architecture for Clinical Diagnosis -- Decision Support Server Architecture for Mobile Medical Applications -- Ordered Time-Independent CIG Learning -- SINCO: Intelligent System in Disease Prevention and Control. An Architectural Approach -- Could a Computer Based System for Evaluating Patients with Suspected Myocardial Infarction Improve Ambulance Allocation? -- On the Robustness of Feature Selection with Absent and Non-observed Features -- Design of a Neural Network Model as a Decision Making Aid in Renal Transplant -- Learning the Dose Adjustment for the Oral Anticoagulation Treatment -- Information Retrieval -- Thermal Medical Image Retrieval by Moment Invariants -- Knowledge Discovery and Data Mining -- Employing Maximum Mutual Information for Bayesian Classification -- Model Selection for Support Vector Classifiers via Genetic Algorithms. An Application to Medical Decision Support -- Selective Classifiers Can Be Too Restrictive: A Case-Study in Oesophageal Cancer -- A Performance Comparative Analysis Between Rule-Induction Algorithms and Clustering-Based Constructive Rule-Induction Algorithms. Application to Rheumatoid Arthritis -- Domain-Specific Particularities of Data Mining: Lessons Learned -- Statistical Methods and Tools for Biological and Medical Data Analysis -- A Structural Hierarchical Approach to Longitudinal Modeling of Effects of Air Pollution on Health Outcomes -- Replacing Indicator Variables by Fuzzy Membership Functions in Statistical Regression Models: Examples of Epidemiological Studies -- PCA Representation of ECG Signal as a Useful Tool for Detection of Premature Ventricular Beats in 3-Channel Holter Recording by Neural Network and Support Vector Machine Classifier -- Finding Relations in Medical Diagnoses and Procedures -- An Automatic Filtering Procedure for Processing Biomechanical Kinematic Signals -- Analysis of Cornea Transplant Tissue Rejection Delay in Mice Subjects -- Toward a Model of Clinical Trials -- Time Series Analysis -- Predicting Missing Parts in Time Series Using Uncertainty Theory -- Classification of Long-Term EEG Recordings -- Application of Quantitative Methods of Signal Processing to Automatic Classification of Long-Term EEG Records -- Semantic Reference Model in Medical Time Series -- Control of Artificial Hand via Recognition of EMG Signals -- Bioinformatics: Data Management and Analysis in Bioinformatics -- SEQPACKER: A Biologist-Friendly User Interface to Manipulate Nucleotide Sequences in Genomic Epidemiology -- Performing Ontology-Driven Gene Prediction Queries in a Multi-agent Environment -- Protein Folding in 2-Dimensional Lattices with Estimation of Distribution Algorithms -- Bioinformatics: Integration of Biological and Medical Data -- Quantitative Evaluation of Established Clustering Methods for Gene Expression Data -- DiseaseCard: A Web-Based Tool for the Collaborative Integration of Genetic and Medical Information -- Biomedical Informatics: From Past Experiences to the Infobiomed Network of Excellence -- Bioinformatics: Metabolic Data and Pathways -- Network Analysis of the Kinetics of Amino Acid Metabolism in a Liver Cell Bioreactor -- Model Selection and Adaptation for Biochemical Pathways -- NeoScreen: A Software Application for MS/MS Newborn Screening Analysis -- Bioinformatics: Microarray Data Analysis and Visualization -- Technological Platform to Aid the Exchange of Information and Applications Using Web Services -- Visualization of Biological Information with Circular Drawings -- Gene Selection Using Genetic Algorithms -- Knowledgeable Clustering of Microarray Data -- Correlation of Expression Between Different IMAGE Clones from the Same UniGene Cluster. |
| Record Nr. | UNINA-9910144333503321 |
| Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2004 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biostatistics decoded [[electronic resource]] / A. Gouveia Oliveira
| Biostatistics decoded [[electronic resource]] / A. Gouveia Oliveira |
| Autore | Oliveira A. Gouveia de |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, England, : Wiley, c2013 |
| Descrizione fisica | 1 online resource (347 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico | Biometry |
| ISBN |
1-118-67079-5
1-118-67076-0 1-118-67078-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Basic concepts -- Statistical inference -- Descriptive studies -- Analytical studies -- Statistical tests -- Issues with statistical tests -- Longitudinal studies -- Statistical modelling -- Measurement -- Experimental studies -- The analysis of experimental studies -- Meta-analysis of clinical trials. |
| Record Nr. | UNINA-9910787564603321 |
|
Oliveira A. Gouveia de
|
||
| Chichester, England, : Wiley, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Biostatistics decoded / / A. Gouveia Oliveira
| Biostatistics decoded / / A. Gouveia Oliveira |
| Autore | Oliveira A. Gouveia de |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, England, : Wiley, c2013 |
| Descrizione fisica | 1 online resource (347 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico | Biometry |
| ISBN |
1-118-67079-5
1-118-67076-0 1-118-67078-7 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Basic concepts -- Statistical inference -- Descriptive studies -- Analytical studies -- Statistical tests -- Issues with statistical tests -- Longitudinal studies -- Statistical modelling -- Measurement -- Experimental studies -- The analysis of experimental studies -- Meta-analysis of clinical trials. |
| Record Nr. | UNINA-9910811758203321 |
|
Oliveira A. Gouveia de
|
||
| Chichester, England, : Wiley, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen
| Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico |
Medicine - Research - Statistical methods
Clinical trials - Methodology |
| ISBN |
0-429-17306-7
1-4822-1219-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
| Record Nr. | UNINA-9910787961903321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen
| Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico |
Medicine - Research - Statistical methods
Clinical trials - Methodology |
| ISBN |
0-429-17306-7
1-4822-1219-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
| Record Nr. | UNINA-9910800183903321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen
| Clinical trial biostatistics and biopharmaceutical applications / / editors, Walter R. Young, Ding-Geng (Din) Chen |
| Pubbl/distr/stampa | Boca Raton : , : CRC Press, , [2015] |
| Descrizione fisica | 1 online resource (574 p.) |
| Disciplina | 610.72/7 |
| Soggetto topico |
Medicine - Research - Statistical methods
Clinical trials - Methodology |
| ISBN |
0-429-17306-7
1-4822-1219-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; List of Figures; List of Tables; Preface; Early History of the DemingConference; Some Nonstatistical Reminiscences of My 44 Years of Chairing the Deming Conference; Contributors; Section I: Emerging Issues in ClinicalTrial Design and Analysis; Chapter 1: Emerging Challenges of Clinical Trial Methodologies in Regulatory Applications; Chapter 2: Review of Randomization Methodsin Clinical Trials; Chapter 3: First Dose Ranging Clinical Trial Design:More Doses? Or aWider Range?; Chapter 4: Thorough QT/QTc Clinical Trials
Chapter 5: Controversial (Unresolved) Issues in Noninferiority TrialsSection II: Adaptive Clinical Trials; Chapter 6: Adaptive Designs in Drug Development; Chapter 7: Optimizing Group-Sequential Designs with Focus on Adaptability: Implications of Nonproportional Hazards in Clinical Trials; Chapter 8: Group Sequential Design in R; Section III: Clinical Trials in Oncology; Chapter 9: Issues in the Design and Analysis of Oncology Clinical Trials; Chapter 10: Competing Risks and Their Applications in Cancer Clinical Trials Chapter 11: Dose Finding with Escalation with Overdose Control in Cancer Clinical TrialsChapter 12: Interval-Censored Time-to-Event Data andT heir Applications in Clinical Trials; Section IV: Multiple Comparisons in Clinical Trials; Chapter 13: Introduction to Multiple Test Problems, with Applications to Adaptive Designs; Chapter 14: Graphical Approaches to Multiple Testing; Chapter 15: Pairwise Comparisons with Binary Responses: Multiplicity-Adjusted P-Values and Simultaneous Confidence Intervals Chapter 16: Comparative Study of Five Weighted Parametric Multiple Testing Methods for Correlated Multiple Endpoints in Clinical TrialsSection V: Clinical Trials in a Genomic Era; Chapter 17: Statistical Analysis of Biomarkers from -Omics Technologies; Chapter 18: Understanding Therapeutic Pathways via Biomarkers and Other Uses of Biomarkers in Clinical Studies; Chapter 19: Statistical Evaluation of Surrogate Endpoints in Clinical Studies; Back Cover |
| Record Nr. | UNINA-9910827747203321 |
| Boca Raton : , : CRC Press, , [2015] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Confidence intervals for proportions and related measures of effect size / / Robert G. Newcombe
| Confidence intervals for proportions and related measures of effect size / / Robert G. Newcombe |
| Autore | Newcombe Robert G. |
| Pubbl/distr/stampa | Boca Raton, Fla. : , : CRC Press, , 2013 |
| Descrizione fisica | 1 online resource (463 p.) |
| Disciplina | 610.72/7 |
| Collana | Chapman & Hall/CRC biostatistics series |
| Soggetto topico |
Biometry
Statistics |
| Soggetto genere / forma | Electronic books. |
| ISBN |
0-429-09261-X
1-4398-1279-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Front Cover; Contents; Preface; Acknowledgments; Author; Acronyms; Chapter 1 - Hypothesis Tests and Confidence Intervals; Chapter 2 - Means and Their Differences; Chapter 3 - Confidence Intervals for a Simple Binomial Proportion; Chapter 4 - Criteria for Optimality; Chapter 5 - Evaluation of Performance of Confidence Interval Methods; Chapter 6 - Intervals for the Poisson Parameter and the Substitution Approach; Chapter 7 - Difference between Independent Proportions and the Square-and-Add Approach; Chapter 8 - Difference between Proportions Based on Individually Paired Data
Chapter 9 - Methods for Triads of ProportionsChapter 10 - Relative Risk and Rate Ratio; Chapter 11 - The Odds Ratio and Logistic Regression; Chapter 12 - Screening and Diagnostic Tests; Chapter 13 - Widening the Applicability of Confidence Interval Methods: The Propagating Imprecision Approach; Chapter 14 - Several Applications of the MOVER and PropImp Approaches; Chapter 15 - Generalised Mann-Whitney Measure; Chapter 16 - Generalised Wilcoxon Measure; References; Appendix 1: Glossary of Some Statistical Terms; Appendix 2: Introduction to Logarithms and Exponentials; Back Cover |
| Record Nr. | UNINA-9910465449903321 |
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Newcombe Robert G.
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| Boca Raton, Fla. : , : CRC Press, , 2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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