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Intro -- Foreword -- Preface -- Contents -- 1: Deciphering the Nexus Between Oxidative Stress and Spermatogenesis: A Compendious Overview -- 1.1 Introduction -- 1.2 Oxidative Stress and Male Infertility -- 1.3 Biochemistry of Reactive Oxygen Species (ROS) -- 1.4 Influence of ROS on Spermatogenesis -- 1.4.1 Lipid Peroxidation -- 1.4.1.1 Lipid Peroxidation -- 1.4.1.2 Strategies for Prevention of Lipid Peroxidation -- 1.4.2 Sperm DNA Fragmentation -- 1.4.2.1 Prevention of Sperm DNA Fragmentation -- 1.4.3 Effect on Sperm Motility -- 1.4.4 Apoptosis -- 1.4.5 Capacitation and Hyperactivation -- 1.5 Idiopathic Male Infertility: A Case Study -- 1.6 Abnormalities That Arise Due to Idiopathic Male Infertility -- 1.7 Peculiarities Among Global Populations -- 1.8 Diagnosis and Treatment -- 1.9 Conclusions -- References -- 2: The Role of Environmental Toxicant-Induced Oxidative Stress in Male Infertility -- 2.1 Introduction to Male Infertility -- 2.2 Environmental Risk Factors and Male Infertility -- 2.3 Pesticides Exposure and Risk of Male Infertility -- 2.3.1 Organophosphate Pesticides (OPs) -- 2.3.2 Organochlorine Pesticides (OCPs) -- 2.3.3 Bisphenol A (BPA) -- 2.4 Phthalates: Steroidogenesis and Spermatogenesis -- 2.4.1 Dioxins -- 2.4.2 Polychlorinated Biphenyls (PCBs) -- 2.4.3 Heavy Metals and Male Infertility -- 2.5 Metabolism of Environmental Pollutants -- 2.6 Environmental Toxicant-Induced Oxidative Stress -- 2.7 Formation of Free Radicals -- 2.8 Sources of ROS -- 2.9 Oxidative Damage to Sperm DNA -- 2.10 Endocrine-Disrupting Chemicals (EDCs) and Male Infertility -- 2.11 Conclusion -- References -- 3: Effect of Environmental Stressors, Xenobiotics, and Oxidative Stress on Male Reproductive and Sexual Health -- 3.1 Introduction -- 3.2 Methods -- 3.3 Environmentally Linked DNA Methylation.
3.3.1 Influence of Environmental Epigenetics in Metals Exposure -- 3.3.1.1 Arsenic -- 3.3.1.2 Nickel -- 3.3.1.3 Lead -- 3.3.1.4 Chromium -- 3.3.1.5 Copper -- 3.3.1.6 Mercury -- 3.3.1.7 Cadmium -- 3.4 Air Pollution and Oxidative Stress (OS) -- 3.4.1 Particulate Matter (PM) -- 3.4.2 Polycyclic Aromatic Hydrocarbons (PAHs) -- 3.4.3 Benzene -- 3.4.4 Volatile Organic Compounds (VOCs) -- 3.5 Persistent Organic Pollutants (POPs) and Endocrine Disruptors (EDs) -- 3.6 Drug-Induced Oxidative Stress (OS) -- 3.7 Tobacco Smoke and Male Infertility -- 3.8 Xenobiotics and Male Infertility -- 3.9 Discussion -- 3.10 Conclusions and Future Perspectives -- References -- 4: Pesticide Toxicity Associated with Infertility -- 4.1 Introduction -- 4.2 Male-Mediated Reproductive Effects -- 4.2.1 Effects on the Testes -- 4.2.2 Effects on Sperm Count and Morphology -- 4.2.3 Effects on Sperm Concentration and Motility -- 4.2.4 Effects on Male Sex Hormones -- 4.3 Female-Mediated Reproductive Effects -- 4.3.1 Effects on Hypothalamus and Pituitary -- 4.3.2 Effects on the Ovary -- 4.3.3 Effects on the Uterus -- 4.3.4 Effects on Fertility -- 4.3.5 Reproductive Senescence -- 4.3.6 Breast Milk Contamination -- 4.4 Insecticides-Induced Toxicity Mitigation Strategies -- 4.5 Conclusion -- References -- 5: Impact of Radiation on Male Fertility -- 5.1 Introduction -- 5.1.1 Ionizing Radiation -- 5.1.2 Non-ionizing Radiation -- 5.2 Ionizing Radiation and Spermatogenesis -- 5.3 Non-ionizing Radiation and Spermatogenesis -- 5.4 Pathophysiology -- 5.4.1 Generation of Oxidative Stress -- 5.4.2 Thermal Effect -- 5.4.3 Calcium Ion Concentration -- 5.4.4 Endocrine Effects -- 5.5 Radiation and Genotoxicity -- 5.5.1 Direct Action -- 5.5.2 Indirect Action -- 5.6 Effects on Semen Parameters -- 5.7 Conclusion -- References.
6: Arsenic-Induced Sex Hormone Disruption: An Insight into Male Infertility -- 6.1 Introduction -- 6.2 Sources of Exposure and Geographical Distribution -- 6.3 Arsenic: Pathways to Disrupt Physiological Functions -- 6.4 Effects of Arsenic on Male Reproduction -- 6.4.1 Effects of Arsenic on Male Gonadal Tissue and Sperm Quality -- 6.4.2 Effects of Arsenic on Male Reproductive Hormones -- 6.5 Arsenic, Oxidative Stress, and Male Reproduction -- 6.6 Oxidative Stress and Sex Hormones: Connecting Link in Male Infertility -- 6.7 Conclusions and Future Perspectives -- References -- 7: A Perspective on Reproductive Toxicity of Metallic Nanomaterials -- 7.1 Introduction -- 7.2 Manganese Nanoparticles (Mn NPs) -- 7.2.1 Effect of Mn NPs on Male Reproductive System -- 7.2.2 Effect of Mn NPs on Embryotoxicity and Teratogenicity -- 7.2.3 In Vitro Toxicity of Mn NPs -- 7.2.4 Mechanism of Mn NPs Toxicity -- 7.2.5 Effect of Mn NPs on Fertility -- 7.3 Silver Nanoparticles (AgNPs) -- 7.3.1 In Vitro Effect of AgNPs -- 7.3.2 Effect of AgNPs on Male Reproductive System -- 7.3.3 Effect of AgNPs on Female Reproductive System -- 7.3.4 Effect of AgNPs on Fertility and Development -- 7.3.5 Reproductive Toxicity of AgNPs on Zebrafish -- 7.4 Gold Nanoparticles (AuNPs) -- 7.4.1 Effect of AuNPs on Male Reproductive System -- 7.4.2 Effect of AuNPs on Female Reproductive System -- 7.4.3 Mechanism of AuNPs Toxicity on Ovarian Follicle -- 7.4.4 Toxicity of AuNPs to Placental Barriers and Embryonic Development -- 7.4.5 Mechanism of AuNPs Toxicity -- 7.5 Titanium Nanoparticles (TiNPs) -- 7.5.1 Effect of TiNPs on Male Reproductive System -- 7.5.2 Biphasic Effect of TiNPs on the Sperm and Testis -- 7.5.3 Effect of TiNPs on Female Reproductive System -- 7.6 Cadmium Nanoparticles (Cd NPs) -- 7.6.1 Effect of Cd NPs on Male Reproductive System.
7.6.2 Effect of Cd NPs on Fertility, Embryo, and Post-natal Development -- 7.7 Conclusion -- References -- 8: Bisphenol A and Male Infertility: Role of Oxidative Stress -- 8.1 Introduction -- 8.2 Bisphenol -- 8.2.1 Overview of Bisphenol -- 8.2.2 Bisphenol A -- 8.3 Toxicokinetics of Bisphenol A -- 8.4 Bisphenol A, Sex Hormones, and Male Fertility -- 8.5 Evidence of Bisphenol A-Induced Male Infertility: The Role of Oxidative Stress -- 8.6 Mechanisms Through Which BPA Impairs Male Fertility -- 8.7 Summary of the Mechanisms Through Which BPA Impairs Male Infertility -- 8.8 Reactive Oxygen Species (ROS) -- 8.8.1 Pathophysiology of ROS in Human Semen -- 8.9 Oxidative Stress -- 8.9.1 Origin of Oxidative Stress -- 8.9.2 Idiopathic -- 8.9.3 Iatrogenic -- 8.9.4 Effect of Oxidative Stress on Male Fertility -- 8.10 Methods of Assessing Oxidative Stress-Related Male Infertility -- 8.10.1 Direct Methods of Identification -- 8.10.2 Indirect Methods of Identification -- 8.11 Male Infertility Treatments and Oxidative Stress Management -- 8.11.1 Antioxidants -- 8.11.2 Testicular Sperm Extraction -- 8.11.3 Cryopreservation -- 8.12 Conclusion -- References -- 9: Oxidative Stress and Male Infertility: Role of Herbal Drugs -- 9.1 Introduction -- 9.2 Pathophysiological Factors of Male Infertility -- 9.2.1 Hormonal Defects -- 9.2.2 Physical Reasons and Sexual Problems -- 9.2.3 Lifestyle and Environment -- 9.2.4 Genetic and Epigenetic Factors -- 9.2.5 Oxidative Stress (OS) -- 9.3 Some Common Plants Used to Treat Male Infertility -- 9.3.1 Nigella sativa (Family: Ranunculaceae) -- 9.3.2 Mucuna pruriens (Family: Fabaceae) -- 9.3.3 Asparagus racemosus (Family: Asparagaceae) -- 9.3.4 Withania somnifera (Family: Solanaceae) -- 9.3.5 Panax ginseng (Family: Araliaceae) -- 9.3.6 Trigonella foenum-graecum (Family: Fabaceae).
9.3.7 Allium sativum (Family: Liliaceae) -- 9.3.8 Shilajit (Asphaltum, Mineral Pitch) -- 9.4 Conclusion -- References -- 10: Natural Products as the Modulators of Oxidative Stress: An Herbal Approach in the Management of Prostate Cancer -- 10.1 Introduction -- 10.2 ROS and Its Signaling in Prostate Cancer Cell Death -- 10.2.1 Apoptosis -- 10.2.2 Autophagy -- 10.2.3 Necrosis -- 10.3 ROS-Mediated Cell Death in Prostate Cancer Through Phytocompounds -- 10.3.1 Apigenin -- 10.3.2 Artesunate -- 10.3.3 Andrographolide -- 10.3.4 Carvacrol -- 10.3.5 Curcumin -- 10.3.6 Guggulsterone -- 10.3.7 Isoalantolactone -- 10.3.8 Parthenolide -- 10.3.9 Plumbagin -- 10.3.10 Sparstolonin B -- 10.4 Structures of the Phytocompounds -- 10.5 Conclusion -- References -- 11: Heat Shock Factors in Protein Quality Control and Spermatogenesis -- 11.1 Introduction -- 11.2 Heat Shock Factors (HSFs) -- 11.3 Heat Shock Proteins (HSPs) -- 11.3.1 HSP27 -- 11.3.2 HSP60 -- 11.3.3 HSP70 -- 11.3.4 HSP90 -- 11.3.5 GRP78 -- 11.4 Phytochemicals as Upregulators of Cellular Protein Quality Control Mechanism -- 11.5 Conclusion and Future Perspective -- References -- 12: Pathological Role of Reactive Oxygen Species on Female Reproduction -- 12.1 Introduction -- 12.2 Pathological Effect of ROS on Female Reproductive System -- 12.2.1 Reduced Growth and Development of Oocycte -- 12.2.2 Ovarian Steroidogenesis -- 12.2.3 Ovulation -- 12.2.4 Formation of Blastocysts -- 12.2.5 Implantation -- 12.3 Luteolysis and Luteal Maintenance of Pregnancy -- 12.4 Endothelial Dysfunction in the Uterus -- 12.5 Fertilization of Eggs -- 12.6 Diseases Caused by ROS in Female Reproductive System -- 12.6.1 Endometriosis -- 12.6.2 Preeclampsia -- 12.6.3 Maternal Diabetes -- 12.6.4 PCOS -- 12.6.5 Hydatidiform Mole -- 12.6.6 Ovarian Epithelial Cancer.
12.6.7 Spontaneous Abortion and Recurrent Pregnancy Loss.
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Oxidative stress and toxicity in reproductive biology and medicine . Volume 2 : a comprehensive update on male infertility / / edited by Shubhadeep Roychoudhury, Kavindra Kumar Kesari
