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Current opinion in cell biology
Current opinion in cell biology
Pubbl/distr/stampa [New York], : Current Science, [1989]-
Disciplina 571.6
Soggetto topico Cells
Cytology
Cells - Periodicals
Cytology - Periodicals
Biology
Review Literature as Topic
Cell Biology
Cellules - Périodiques
Cytologie - Périodiques
Cellules
Cytologie
Revues de la littérature
Biologie
biology
Soggetto genere / forma Periodical
Periodicals.
ISSN 1879-0410
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNISA-996204838703316
[New York], : Current Science, [1989]-
Materiale a stampa
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Current opinion in cell biology
Current opinion in cell biology
Pubbl/distr/stampa [New York], : Current Science, [1989]-
Disciplina 571.6
Soggetto topico Cells
Cytology
Cells - Periodicals
Cytology - Periodicals
Biology
Review Literature as Topic
Cell Biology
Cellules - Périodiques
Cytologie - Périodiques
Cellules
Cytologie
Revues de la littérature
Biologie
biology
Soggetto genere / forma Periodical
Periodicals.
ISSN 1879-0410
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910142564103321
[New York], : Current Science, [1989]-
Materiale a stampa
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Cytologia
Cytologia
Pubbl/distr/stampa Tokyo, : K. Fujii
Descrizione fisica 1 online resource
Disciplina 442.8
Altri autori (Persone) FujiiKenjiro
Soggetto topico Cells
Cytology
Cell Biology
Cytologie
Cellules
Celbiologie
Soggetto genere / forma Periodical
Periodicals.
ISSN 1348-7019
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910555230803321
Tokyo, : K. Fujii
Materiale a stampa
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Developmental cell
Developmental cell
Pubbl/distr/stampa Cambridge, Mass., : Cell Press, ©2001-
Soggetto topico Cytology
Developmental biology
Cells
Developmental Biology
Soggetto genere / forma Periodical
Fulltext
Internet Resources.
Periodicals.
Soggetto non controllato Cytology
ISSN 1878-1551
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910134106503321
Cambridge, Mass., : Cell Press, ©2001-
Materiale a stampa
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Developmental cell
Developmental cell
Pubbl/distr/stampa Cambridge, Mass., : Cell Press, ©2001-
Soggetto topico Cytology
Developmental biology
Cells
Developmental Biology
Soggetto genere / forma Periodical
Fulltext
Internet Resources.
Periodicals.
Soggetto non controllato Cytology
ISSN 1878-1551
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNISA-996540072503316
Cambridge, Mass., : Cell Press, ©2001-
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Differentiated lymphocyte functions
Differentiated lymphocyte functions
Pubbl/distr/stampa [Place of publication not identified], : Karger, 1981
Descrizione fisica 1 online resource (X + 286 pages) : : 47 figures, 26 tables
Soggetto topico Leukocytes, Mononuclear
Leukocytes
Immune System
Blood Cells
Blood
Cells
Hemic and Immune Systems
Anatomy
Lymphocytes
ISBN 3-318-01538-5
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Record Nr. UNINA-9910155291603321
[Place of publication not identified], : Karger, 1981
Materiale a stampa
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Engineering Translational Models of Lung Homeostasis and Disease [[electronic resource] /] / edited by Chelsea M. Magin
Engineering Translational Models of Lung Homeostasis and Disease [[electronic resource] /] / edited by Chelsea M. Magin
Edizione [1st ed. 2023.]
Pubbl/distr/stampa Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Descrizione fisica 1 online resource (328 pages)
Disciplina 262
Collana Advances in Experimental Medicine and Biology
Soggetto topico Regenerative medicine
Biomedical engineering
Cytology
Biomaterials
Cells
Biotechnology
Regenerative Medicine and Tissue Engineering
Biomedical Engineering and Bioengineering
Cell Biology
Biomaterials-Cells
Soggetto non controllato Physiology
Science
ISBN 9783031266256
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Intro -- Foreword -- Preface -- Contents -- Chapter 1: An Introduction to Engineering and Modeling the Lung -- 1.1 Introduction -- 1.2 Broader Impacts of Understanding Lung Biology in Health and Disease -- 1.3 Lung Physiology in Homeostasis and Disease -- 1.4 Engineering Translational Models of Lung Homeostasis and Disease -- 1.5 Conclusion -- References -- Part I: Engineering and Modeling the Developing Lung -- Chapter 2: Simple Models of Lung Development -- 2.1 Introduction -- 2.1.1 Basics of Lung Development -- 2.2 Models to Study Lung Development -- 2.3 Models of Early Lung Development (Airways) -- 2.3.1 Explant Cultures -- 2.3.2 2D and 3D Imaging of Branching Morphogenesis -- 2.3.3 Time-Lapse Imaging -- 2.3.4 Organoids -- 2.4 Models of Late Lung Development -- 2.4.1 Saccular Phase Models -- 2.4.2 Alveologenesis -- 2.4.3 Other 3D Models of Alveologenesis -- 2.5 Conclusion -- References -- Chapter 3: Lung Development in a Dish: Models to Interrogate the Cellular Niche and the Role of Mechanical Forces in Development -- 3.1 Introduction -- 3.2 Self-Assembled Organoid and Spheroid Models -- 3.2.1 Creating Lung Organoid Models That Represent Regional Composition and Heterogeneity -- 3.2.2 Advancing the Complexity of Organoids to Investigate Tissue Crosstalk -- 3.2.3 Induction of Lung Organoids to Create Multiple Tissue Compartments -- 3.3 Microfluidic and Organ-on-a-Chip Models to Study Lung Development -- 3.3.1 Moving Toward More Complex Physiology with Multiple Channels -- 3.3.2 Integration of Dimensionality and Biomaterials into Organ-on-a-Chip Platforms -- 3.4 Whole Organ Models to Understand the Mechanics of Lung Development -- 3.5 Conclusion -- References -- Chapter 4: Multipotent Embryonic Lung Progenitors: Foundational Units of In Vitro and In Vivo Lung Organogenesis -- 4.1 Introduction -- 4.2 Overview of Embryonic Lung Progenitors.
4.2.1 Stage-Specific Epithelial Progenitors (Primordial, Distal Tip, Basal) -- Lung Primordial Progenitors -- Distal Tip Progenitors -- Airway Basal Cells -- 4.2.2 Stage-Specific Mesenchymal Progenitors -- 4.3 Ex Vivo Culture of Multipotent Embryonic Lung Progenitors -- 4.3.1 Ex Vivo Culture of Mouse Embryonic Progenitors -- 4.3.2 Ex Vivo Culture of Human Embryonic Progenitors -- 4.4 In Vitro Derivation of Multipotent Embryonic Lung Progenitors -- 4.5 Progenitor Cell Similarity Models -- 4.6 Conclusion -- References -- Part II: Engineering and Modeling Large Airways -- Chapter 5: Basic Science Perspective on Engineering and Modeling the Large Airways -- 5.1 Introduction -- 5.2 Proximal Airways: Composition and Function -- 5.3 Regeneration of the Airways -- 5.3.1 Endogenous Stem Cells -- 5.3.2 The Stem Cell Niche -- 5.3.3 Stem Cell Attrition with Disease and Aging -- 5.4 Developing Cellular Therapies for Regeneration of Airway Tissues -- 5.5 In Vitro Models of the Human Airways -- 5.5.1 Transwell Air-Liquid Interface (ALI) Cultures -- 5.5.2 Airway Spheroids: Tracheo/Bronchospheres -- 5.5.3 Organoids -- 5.5.4 Lung-on-a-Chip -- 5.5.5 Xenografts -- 5.6 Cell-Matrix Interactions -- 5.7 Conclusion -- References -- Chapter 6: Computational, Ex Vivo, and Tissue Engineering Techniques for Modeling Large Airways -- 6.1 Large Airways: Structure-Function Relationship -- 6.2 Pathologies and the Need for Modeling the Large Airways -- 6.2.1 Conditions That Cause Large Airway Dysfunction -- 6.2.2 Need for Computational and Physiological Models of the Large Airways -- 6.3 Computational Modeling -- 6.4 Ex Vivo Testing -- 6.5 Tissue Engineering Techniques for Modeling the Large Airways -- 6.5.1 Biomaterial Scaffolds -- Decellularized Scaffolds -- Cellular, Synthetic, or Hybrid Biomaterial Approaches -- 6.5.2 Manufacturing Techniques for Large Airway Models.
6.6 Tools for Functional Assessment of Large Airway Models -- 6.7 Limitations and Future Considerations -- References -- Chapter 7: Engineering Large Airways -- 7.1 Introduction -- 7.2 Forces During Respiration and How They Can Influence Construct Design -- 7.3 The Structure of the Trachea and Its Mechanical Properties -- 7.3.1 Tracheal Cartilage -- 7.3.2 Trachealis Muscle -- 7.3.3 Annular Ligament -- 7.4 Mechanical Properties of the Whole Trachea and the Implications of Mechanical Property Mismatch -- 7.4.1 Compliance -- 7.4.2 Extension and Bending -- 7.5 Key Considerations and Summary of Recommended Mechanical Tests -- 7.6 Conclusion -- References -- Part III: Engineering and Modeling the Mesenchyme and Parenchyma -- Chapter 8: Engineering and Modeling the Lung Mesenchyme -- 8.1 Introduction -- 8.2 Advancing the Discovery of Fibroblast Heterogeneity -- 8.3 The Organization and Heterogeneity of Lung Fibroblasts -- 8.3.1 Platelet-Derived Growth Factor Receptor Alpha (PDGFRα)-Expressing Alveolar Fibroblasts 1 and 2 -- 8.3.2 Platelet-Derived Growth Factor Beta (PDGFRβ)-Expressing Pericytes -- 8.3.3 Airway and Vascular Smooth Muscle (ASM and VSM) -- 8.4 Other Fibroblast Subtypes -- 8.4.1 Developmental Secondary Crest Myofibroblasts (SCMF) -- 8.4.2 Fibrotic Disease-Associated Myofibroblasts (MyoF) -- 8.5 Bioengineering Approaches to Characterize Complex Fibroblast Behaviors -- 8.5.1 Organoids to Model Mesenchymal-Epithelial Interactions -- 8.5.2 Lung-on-a-Chip to Model Human Lung Architecture and Environmental Forces -- 8.5.3 Acellular Tissue Scaffolds to Model Fibroblast and ECM Interactions -- 8.6 Targeting Fibroblasts with Nanoparticles as Strategy for Intervention -- 8.7 Conclusion -- References -- Chapter 9: Engineering Dynamic 3D Models of Lung -- 9.1 Introduction -- 9.2 Building the Extracellular Microenvironment -- 9.2.1 Biomaterials.
9.2.2 Lung Decellularization and Recellularization -- 9.2.3 dECM Hydrogels -- 9.2.4 Synthetic Hydrogels -- 9.2.5 Hybrid-Hydrogels -- 9.3 Constructing Relevant Tissue Geometries -- 9.3.1 Precision-Cut Lung Slices -- 9.3.2 Organoids -- 9.3.3 Engineered 3D Hydrogel Constructs -- 9.3.4 3D Bioprinting -- 9.4 Incorporating Dynamic Mechanical Forces -- 9.4.1 Biomechanical Modeling -- 9.4.2 Lung-on-a-Chip -- 9.5 Conclusion -- References -- Chapter 10: Lung-on-a-Chip Models of the Lung Parenchyma -- 10.1 Introduction -- 10.2 Lung Alveolar Cells and the Alveolar Environment -- 10.2.1 Lung Alveolar Cells and Their Environment -- 10.2.2 Lung Alveolar Epithelial Cells In Vitro -- 10.3 Reproducing the Alveolar Barrier with a Lung-on-a-Chip -- 10.3.1 Reproducing the Lung Alveolar Environment on Chip -- Scaffolds for the Alveolar Barrier: Engineering a Thin, Flexible and Soft Basement Membrane -- Mechanical Stress Induced by the Respiratory Movements -- 10.3.2 Effects of Biochemical and Physical Cues on the Lung Alveolar Barrier -- Effects of Mechanical Forces on Alveolar Epithelial Cells -- Effects of Mechanical Forces on Lung Endothelial Cells -- Lung Alveolar Extracellular Matrix (ECM) -- Effects Induced by the Air-Liquid Interface -- 10.3.3 Read-Outs: Extracting Information from a Lung-on-a-Chip -- 10.4 Lung Disease-on-a-Chip Models -- 10.4.1 Idiopathic Pulmonary Fibrosis (IPF) -- 10.4.2 Emphysema -- 10.4.3 Acute Respiratory Distress Syndrome (ARDS) -- 10.4.4 COVID -- 10.4.5 Lung Adenocarcinoma -- 10.5 Challenges of Lung-on-a-Chip Technologies -- 10.6 Perspectives for Lung-on-a-Chip Technologies -- References -- Chapter 11: Assessment of Collagen in Translational Models of Lung Research -- 11.1 Introduction -- 11.2 Quantification of Collagen -- 11.2.1 The Sircol Assay -- 11.2.2 Hydroxyproline Quantification -- 11.2.3 Immuno-Based Methods.
11.3 Mass Spectrometry Characterization of Collagen -- 11.3.1 Assessment of Collagens in Proteomics Analyses of Pulmonary ECM -- 11.3.2 Analysis of Posttranslational Modifications of Collagen -- 11.3.3 Assessment of Enzymatic Crosslinks in Collagen -- 11.4 Assessment of Collagen Architecture In Situ -- 11.4.1 Masson's Trichrome Staining -- 11.4.2 Picrosirius Red Staining -- 11.4.3 Second Harmonic Generation Microscopy -- 11.4.4 Immunohistochemistry -- 11.4.5 Transmission Electron Microscopy -- 11.4.6 Selected Complementary and Emerging Techniques -- Confocal Reflection Microscopy (CRM) -- Atomic Force Microscopy (AFM) -- Imaging Probes for Magnetic Resonance Imaging (MRI) -- 11.5 Monitoring Fibril Formation in Real Time Using Purified Collagen -- 11.6 Assessment of Collagen Turnover by Peripheral Markers -- 11.7 Conclusion -- References -- Part IV: Engineering and Modeling the Pulmonary Vasculature -- Chapter 12: Understanding and Engineering the Pulmonary Vasculature -- 12.1 Pulmonary Vasculature in Development and Diseases -- 12.2 Pulmonary ECs and Their Angiocrine Functions -- 12.3 Engineering the Pulmonary Vasculature -- 12.3.1 Generation of Vascularized Organoids -- 12.3.2 Bioengineered Lung and Vasculature Using Acellular Native Lung Scaffold -- 12.3.3 Vascularized Lung-on-a-Chip -- 12.3.4 Guided Vascularization Through 3D Bioprinting -- 12.4 Pulmonary Vascular Diseases -- 12.5 Conclusion -- References -- Chapter 13: An Overview of Organ-on-a-Chip Models for Recapitulating Human Pulmonary Vascular Diseases -- 13.1 Introduction -- 13.2 Microfluidics and Organ-on-a-Chip -- 13.2.1 Concepts -- Microfluidics in Vascular Biology -- Patterning Microvascular Networks -- 13.3 OoC for Pulmonary Vascular Diseases -- 13.4 Conclusion -- References -- Chapter 14: Clinical Translation of Engineered Pulmonary Vascular Models -- 14.1 Introduction.
14.2 Brief Overview of Pulmonary Vascular Physiology.
Record Nr. UNINA-9910733729003321
Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023
Materiale a stampa
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Frontiers in cell and developmental biology
Frontiers in cell and developmental biology
Pubbl/distr/stampa Lausanne : , : Frontiers Media S.A., , [2013]-
Descrizione fisica 1 online resource
Soggetto topico Cells
Developmental biology
Developmental Biology
Soggetto genere / forma Fulltext
Internet Resources.
Periodicals.
Periodical
Soggetto non controllato Cytology
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNISA-996321886403316
Lausanne : , : Frontiers Media S.A., , [2013]-
Materiale a stampa
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Frontiers in cell and developmental biology
Frontiers in cell and developmental biology
Pubbl/distr/stampa Lausanne : , : Frontiers Media S.A., , [2013]-
Descrizione fisica 1 online resource
Soggetto topico Cells
Developmental biology
Developmental Biology
Soggetto genere / forma Fulltext
Internet Resources.
Periodicals.
Periodical
Soggetto non controllato Cytology
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Record Nr. UNINA-9910140357903321
Lausanne : , : Frontiers Media S.A., , [2013]-
Materiale a stampa
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Genes to cells
Genes to cells
Pubbl/distr/stampa [Oxford, England] : , : Blackwell Science Limited
Descrizione fisica 1 online resource
Soggetto topico Cytogenetics
Cells - Mechanical properties
Molecular genetics
Genes
Molecular biology
Cytology
Biomechanics
Cells
Gene expression
Gene rearrangement
Cellular signal transduction
Cell Division
Gene Expression
Gene Rearrangement
Molecular Biology
Signal Transduction
Cytogénétique
Cellules - Propriétés mécaniques
Génétique moléculaire
Gènes
Biologie moléculaire
Cytologie
Biomécanique
Cellules
Expression génique
Réarrangement des gènes
Transduction du signal cellulaire
Histology
Soggetto genere / forma Periodical
periodicals.
Periodicals.
Périodique électronique (Descripteur de forme)
Ressource Internet (Descripteur de forme)
Périodiques.
ISSN 1365-2443
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Altri titoli varianti Genes cells
Record Nr. UNISA-996213443303316
[Oxford, England] : , : Blackwell Science Limited
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