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Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1995
Descrizione fisica 1 online resource (367 p.)
Disciplina 615.10285
615.1900285
Altri autori (Persone) WaterbeemdHan van de
Collana Methods and principles in medicinal chemistry
Soggetto topico Pharmaceutical chemistry - Data processing
Drugs - Design - Data processing
Drugs - Research - Data processing
QSAR (Biochemistry)
Soggetto genere / forma Electronic books.
ISBN 1-281-84288-5
9786611842888
3-527-61567-9
3-527-61566-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples
2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; 2.2.3.1 Results of the Analysis
2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References
3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods
3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies
3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques
Record Nr. UNINA-9910144110203321
Weinheim ; ; New York, : VCH, c1995
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1995
Descrizione fisica 1 online resource (367 p.)
Disciplina 615.10285
615.1900285
Altri autori (Persone) WaterbeemdHan van de
Collana Methods and principles in medicinal chemistry
Soggetto topico Pharmaceutical chemistry - Data processing
Drugs - Design - Data processing
Drugs - Research - Data processing
QSAR (Biochemistry)
ISBN 1-281-84288-5
9786611842888
3-527-61567-9
3-527-61566-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples
2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; 2.2.3.1 Results of the Analysis
2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References
3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods
3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies
3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques
Record Nr. UNISA-996217063403316
Weinheim ; ; New York, : VCH, c1995
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1995
Descrizione fisica 1 online resource (367 p.)
Disciplina 615.10285
615.1900285
Altri autori (Persone) WaterbeemdHan van de
Collana Methods and principles in medicinal chemistry
Soggetto topico Pharmaceutical chemistry - Data processing
Drugs - Design - Data processing
Drugs - Research - Data processing
QSAR (Biochemistry)
ISBN 1-281-84288-5
9786611842888
3-527-61567-9
3-527-61566-0
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples
2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; 2.2.3.1 Results of the Analysis
2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References
3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods
3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies
3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques
Record Nr. UNINA-9910830440503321
Weinheim ; ; New York, : VCH, c1995
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced computer-assisted techniques in drug discovery / / edited by Han van de Waterbeemd
Advanced computer-assisted techniques in drug discovery / / edited by Han van de Waterbeemd
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1995
Descrizione fisica 1 online resource (367 p.)
Disciplina 615/.19/00285
Altri autori (Persone) WaterbeemdHan van de
Collana Methods and principles in medicinal chemistry
Soggetto topico Pharmaceutical chemistry - Data processing
Drugs - Design - Data processing
Drugs - Research - Data processing
QSAR (Biochemistry)
ISBN 9786611842888
9781281842886
1281842885
9783527615674
3527615679
9783527615667
3527615660
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples
2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; 2.2.3.1 Results of the Analysis
2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References
3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods
3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies
3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques
Record Nr. UNINA-9911019502003321
Weinheim ; ; New York, : VCH, c1995
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced materials
Advanced materials
Pubbl/distr/stampa Weinhem, : VCH
ISSN 0935-9648
Formato Materiale a stampa
Livello bibliografico Periodico
Lingua di pubblicazione eng
Note periodicità Mensile
Record Nr. UNINA-990008886240403321
Weinhem, : VCH
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced organic chemistry of nucleic acids [[electronic resource] /] / Z. Shabarova, A. Bogdanov
Advanced organic chemistry of nucleic acids [[electronic resource] /] / Z. Shabarova, A. Bogdanov
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim ; ; New York, : VCH, c1994
Descrizione fisica 1 online resource (606 p.)
Disciplina 547.79
574.87328
Altri autori (Persone) BogdanovA (Alexey)
Soggetto topico Nucleic acids
Chemistry, Organic
Soggetto genere / forma Electronic books.
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNINA-9910144008903321
Shabarova Z (Zoe)  
Weinheim ; ; New York, : VCH, c1994
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Descrizione fisica 1 online resource (606 p.)
Disciplina 574.87328
Soggetto topico Nucleic acids
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNISA-996197616303316
Shabarova Z (Zoe)  
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Materiale a stampa
Lo trovi qui: Univ. di Salerno
Opac: Controlla la disponibilità qui
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Advanced organic chemistry of nucleic acids / / Z. Shabarova, A. Bogdanov, translated by Vladimir Vopyan
Autore Shabarova Z (Zoe)
Pubbl/distr/stampa Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Descrizione fisica 1 online resource (606 p.)
Disciplina 574.87328
Soggetto topico Nucleic acids
ISBN 1-281-75881-7
9786611758813
3-527-61593-8
3-527-61592-X
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advanced Organic Chemistry of Nucleic Acids; Contents; 1 Structure of Nucleosides; 1.1 Introduction; 1.2 Pyrimidine and Purine Bases; 1.2.1 Pyrimidines; 1.2.2 Purines; 1.2.3 Nomenclature of Pyrimidines and Purines; 1.2.4 Abbreviations; 1.3 Carbohydrate Moieties of Nucleosides; 1.4 Bonding Between Carbohydrate Moiety and Heterocyclic Base; 1.4.1 Purine Nucleosides; 1.4.2 Pyrimidine Nucleosides; 1.5 Size of the Oxide Ring in the Sugar; 1.6 Configuration of the Glycoside (Anomeric) Center; 1.7 Nomenclature and Abridged Formulas of Nucleosides; 1.8 Minor Nucleosides; 1.9 Pseudouridine
1.10 Nucleoside Antibiotics1.10.1 Purine Nucleosides; 1.10.2 Pyrimidine Nucleosides; 1.11 Other Nucleosides; References; 2 Properties of Nucleosides; 2.1 Heterocyclic Bases; 2.1.1 General Concepts; 2.1.2 Tautomerism; 2.1.3 Reactions with Electrophilic Reagents; 2.1.4 Reactions with Nucleophilic Reagents; 2.1.5 Addition Reactions; 2.1.6 Reactions Involving Exocyclic Amino Groups; 2.2 Reactions at the Carbohydrate Moiety; 2.2.1 Substitution for Hydrogen Atoms in Hydroxyl Groups; 2.2.2 Oxidation; 2.3 Reactions Involving Heterocyclic Bases and the Carbohydrate Moiety
2.4 Stability of N-Glycosidic Bonds2.4.1 Effect of the Heterocyclic Base Species; 2.4.2 Effect of Substituents in the Carbohydrate Moiety; 2.4.3 Mechanism of Hydrolysis of N-Glycosidic Bonds; 2.5 Properties of Pseudouridine; References; 3 Structure of Nucleotides; 3.1 Introduction; 3.2 Nomenclature and Isomerism; 3.3 Structure of Nucleotides; 3.3.1 Nucleoside 5'-Phosphates; 3.3.2 Nucleoside 3'- and 2'-Phosphates; 3.3.3 Nucleoside Cyclic Phosphates; 3.3.4 Nucleoside 3'(2').5'-Diphosphates; 3.4 General Comments Regarding the Structure of Monomer Units in Nucleic Acids; References
4 Properties of Nucleotides4.1 Acid-Base Behavior; 4.1.1 Ionization of Bases; 4.1.2 Ionization of Hydroxyl Groups in Pentose; 4.1.3 Ionization of the Phosphate Group; 4.2 Formation of Derivatives with Metals; 4.3 Reactions at Heterocyclic Bases and Pentose; 4.4 Some Properties of the Phosphate Group (General Concepts); 4.4.1 Structure of the Phosphate Group and the Mechanism of Nucleophilic Substitution at the Phosphorus Atom; 4.4.2 Catalysis of Nucleophilic Substitution at the Phosphorus Atom; 4.4.3 Hydrolysis of Alkyl Phosphates; 4.4.4 Cyclic Phosphates; 4.4.5 B-Elimination Reactions
4.5 Reactions of Nucleotides Involving the Phosphate Group4.5.1 Chemical and Enzymatic Dephosphorylation; 4.5.2 Migration of the Phosphate Group; 4.5.3 Alkylation of the Phosphate Group; 4.5.4 Activation of the Phosphate Group in Nucleotides . Synthesis of Some Derivatives with Respect to the Phosphate Group; 4.5.5 Acylation of the Phosphate Group; 4.6 Properties of Nucleotide Derivatives with Substituents in the Phosphate Group; 4.6.1 Nucleoside Cyclic Phosphates; 4.6.2 Alkyl Esters of Nucleotides; 4.6.3 Mixed Anhydrides of Nucleotides; 4.6.4 Amides of Nucleotides
4.7 Hydrolysis of N-Glycosidic Bonds
Record Nr. UNINA-9910830338503321
Shabarova Z (Zoe)  
Weinheim, Germany ; ; New York, New York : , : VCH, , [1994]
Materiale a stampa
Lo trovi qui: Univ. Federico II
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Advanced organic chenistry of nucleic acids / [by] Z. Shabarova, A. Bogdanov ; [translator Vladimir Vopyan
Advanced organic chenistry of nucleic acids / [by] Z. Shabarova, A. Bogdanov ; [translator Vladimir Vopyan
Autore Shabarova, Zoe
Pubbl/distr/stampa Weinheim : VCH, 1994
Descrizione fisica XV, 588 p. ; 24 cm
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione ita
Record Nr. UNINA-990002231220403321
Shabarova, Zoe  
Weinheim : VCH, 1994
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui
Advances in electrochemical science and engineering . Volume 7 [[electronic resource] /] / edited by Richard C. Alkire and Dieter M. Kolb
Advances in electrochemical science and engineering . Volume 7 [[electronic resource] /] / edited by Richard C. Alkire and Dieter M. Kolb
Pubbl/distr/stampa Weinheim ; ; New York, NY, USA, : VCH, 2002
Descrizione fisica 1 online resource (363 p.)
Disciplina 541.37
Altri autori (Persone) AlkireR. C. <1941->
KolbDieter M
Collana Advances in electrochemical science and engineering
Soggetto topico Electrochemistry
Chemistry, Physical and theoretical
Soggetto genere / forma Electronic books.
ISBN 1-280-55770-2
9786610557707
3-527-61690-X
3-527-60026-4
Formato Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione eng
Nota di contenuto Advances in Electrochemical Science and Engineering; Contents; Electrochemical Atomic Layer Epitaxy (EC-ALE): Nanoscale Control in the Electrodeposition of Compound Semiconductors; The Initial Stages of Metal Deposition as Viewed by Scanning Tunneling Microscopy; Structure and Pattern Formation in Electrodeposition; Review of Electrocodeposition; Fundamental and Practical Aspects of the Electroless Deposition Reaction; Electrodeposition of Transition Metal-Aluminum Alloys from Chloroaluminate Molten Salts; Index
Record Nr. UNINA-9910146053903321
Weinheim ; ; New York, NY, USA, : VCH, 2002
Materiale a stampa
Lo trovi qui: Univ. Federico II
Opac: Controlla la disponibilità qui