Autore	Gomperts, Bastien D.
Edizione	[2nd ed.]
Pubbl/distr/stampa	Amsterdam [etc.] : Elsevier, c2009
Descrizione fisica	xxvii, 810 p. : ill. (col.) ; 24 cm
Disciplina	571.6
Altri autori (Persone)	Kramer, Ijsbrand M.
Soggetto non controllato	Biologia cellulare Biochimica
ISBN	978-0-12-369441-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-990009427660403321

Autore	Gomperts B. D
Edizione	[2nd ed.]
Pubbl/distr/stampa	Burlington, M.A. ; ; London, : Elsevier/Academic Press, c2009
Descrizione fisica	xxvii, 810 p. : col. ill
Disciplina	571.6
Altri autori (Persone)	TathamPeter E. R KramerIjsbrand M
Soggetto topico	Cellular signal transduction Cellular control mechanisms
ISBN	1-68015-089-8 0-08-091905-7 1-282-28541-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Record Nr.	UNINA-9911007157003321

Autore	Gomperts B. D
Pubbl/distr/stampa	San Diego, Calif., : Academic Press, c2002
Descrizione fisica	1 online resource (441 p.)
Disciplina	571.6
Altri autori (Persone)	TathamPeter E. R KramerIjsbrand M
Soggetto topico	Cellular signal transduction
ISBN	1-281-07062-9 9786611070625 0-12-289632-7 0-08-054118-6
Formato	Materiale a stampa
Livello bibliografico	Monografia
Lingua di pubblicazione	eng
Nota di contenuto	Front Cover; Signal Transduction; Copyright Page; Contents; Preface; Chapter 1. Prologue: Signal transduction, origins and personalities; Transduction, the word and its meaning: one dictionary, different points of view; Hormones, evolution and history; Hormones: a definition; Neurotransmitters; Ergot; Receptors and ligands; Chapter 2. First messengers; Hormones; Binding of ligands to receptors; Chapter 3. Receptors; Adrenaline (again); a- and ß-adrenergic receptors; Acetylcholine receptors; Ion channel-linked receptors; The 7TM superfamily of G-protein linked receptors Receptor-ligand interaction and receptor activationTransmitting signals into cells; Intracellular 7TM receptor domains and signal transmission; Adrenaline (yet again); Chapter 4. GTP-binding proteins and signal transduction; Nucleotides as metabolic regulators; GTP-binding proteins, G-proteins or GTPases; Ras proteins; Ras-GAPs; Essay: Activation of G-proteins without subunit dissociation; Chapter 5. Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C; Adenylyl cyclase; Phospholipase C; Chapter 6. The regulation of visual transduction Sensitivity of photoreceptorsPhotoreceptor mechanisms; Adaptation: calcium acts as a negative regulator; Photo-excitation of rhodopsin; Switching off the mechanism; A note on phototransduction in invertebrates; Chapter 7. Calcium and signal transduction; A new second messenger is discovered; Calcium and evolution; Distinguishing Ca2+ and Mg2+; Free, bound and trapped Ca2+; Cytosol Ca2+ is kept low; Detecting changes in cytosol Ca2+; Mechanisms that elevate cytosol Ca2+ concentration; The pattern of cytosol Ca2+ changes in single cells; Localization of intracellular second messengers Chapter 8. Calcium signallingCalcium binding by proteins; Effects of elevated calcium; Paradigms of calcium signalling; Chapter 9. Phosphorylation and dephosphorylation: Protein kinases A and C; Protein phosphorylation as a switch in cellular functioning; cAMP and the amplification of signals; Protein kinase A; Protein kinase A and the regulation of transcription; Protein kinase A and the activation of ERK; Actions of cAMP not mediated by PKA; Protein kinase C; The protein kinase C family; Structural domains and activation of protein kinase C Multiple sources of DAG and other lipids to activate PKCDifferential localization of PKC isoforms; PKC anchoring proteins, STICKs, PICKs and RACKs; PKC and cell transformation; PKC and inflammation; Chapter 10. Growth factors: Setting the framework; Viruses and tumours; The discovery of NGF... and EGF; Platelet derived growth factor; Transforming growth factors; Problems with nomenclature; Essay: The cell cycle; Essay: Cancer and cell transformation; Chapter 11. Signalling pathways operated by receptor protein tyrosine kinases; The tyrosine kinase family; Tyrosine kinase-containing receptors Branching of the signalling pathway
Record Nr.	UNINA-9910784528003321