Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
Drug discovery [[electronic resource] ] : practices, processes, and perspectives / / edited by Jie Jack Li, E.J. Corey
| Drug discovery [[electronic resource] ] : practices, processes, and perspectives / / edited by Jie Jack Li, E.J. Corey |
| Pubbl/distr/stampa | Hoboken, N.J., : John Wiley & Sons, c2013 |
| Descrizione fisica | 1 online resource (572 p.) |
| Disciplina | 615.1/9 |
| Altri autori (Persone) |
LiJie Jack
CoreyE. J |
| Soggetto topico |
Drug development
Pharmaceutical chemistry |
| ISBN |
1-118-35447-8
1-118-35448-6 1-299-46484-X 1-118-35446-X |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | History of drug discovery -- Target identification and validation -- In vitro and in vivo assays -- Drug metabolism and pharmacokinetics in drug discovery -- Cardiovascular drugs -- Diabetes drugs -- CNS drugs -- Cancer drugs -- Antiinflammatory and immunomodulatory drugs -- Anti-bacterial drugs -- Antiviral drug discovery. |
| Record Nr. | UNINA-9910139018803321 |
| Hoboken, N.J., : John Wiley & Sons, c2013 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Enantioselective chemical synthesis : methods, logic and practice / E.J. Corey and László Kürti
| Enantioselective chemical synthesis : methods, logic and practice / E.J. Corey and László Kürti |
| Autore | Corey, E. J |
| Pubbl/distr/stampa | Dallas (Texas) : Direct Book Publishing, 2010 |
| Descrizione fisica | VI, 328 p. : ill. ; 26 cm. |
| Disciplina |
547.2
547.1223 |
| Altri autori (Persone) | Kürti, László |
| Soggetto topico | Reazioni chimiche organiche - Sintesi |
| ISBN | 978-0-615-39515-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNIBAS-000039015 |
Corey, E. J
|
||
| Dallas (Texas) : Direct Book Publishing, 2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. della Basilicata | ||
| ||
Erythronolide B.p. 167-184
| Erythronolide B.p. 167-184 |
| Altri autori (Persone) | Corey, E.J. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | und |
| Record Nr. | UNINA-990002353560403321 |
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
|
Ginkgolide B.p. 451-464
| Ginkgolide B.p. 451-464 |
| Altri autori (Persone) | Corey, E.J. |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | und |
| Record Nr. | UNINA-990002353700403321 |
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
|
The logic of chemical synthesis / E. J. Corey and Xue-Min Cheng
| The logic of chemical synthesis / E. J. Corey and Xue-Min Cheng |
| Autore | Corey, E. J. |
| Pubbl/distr/stampa | New York : John Wiley & Sons, c1989 |
| Descrizione fisica | [18], 436 p. : ill. ; 26 cm |
| Disciplina | 547.2 |
| Altri autori (Persone) | Cheng, Xue-Minauthor |
| Soggetto topico |
Chemistry, Organic - Synthesis
Organic compounds - Synthesis |
| ISBN | 0471509795 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991003506249707536 |
|
Corey, E. J.
|
||
| New York : John Wiley & Sons, c1989 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
Molecules and medicine / E.J. Corey, Barbara Czakò, Laszlo Kurti
| Molecules and medicine / E.J. Corey, Barbara Czakò, Laszlo Kurti |
| Autore | COREY, E.J. |
| Pubbl/distr/stampa | Hoboken : Wiley, copyr. 2007 |
| Descrizione fisica | XII, 254 p. : ill. ; 26 cm |
| Disciplina | 615.1 |
| Altri autori (Persone) |
CZAKO, Barbara
KURTI, Laszlo |
| Soggetto topico |
Biologia molecolare
Farmaci - Analisi chimica |
| ISBN | 978-0-470-26096-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISA-990003127170203316 |
|
COREY, E.J.
|
||
| Hoboken : Wiley, copyr. 2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Molecules and medicine / E. J. Corey, B. Czakâo and L. Kèurti
| Molecules and medicine / E. J. Corey, B. Czakâo and L. Kèurti |
| Autore | Corey, E. J. |
| Pubbl/distr/stampa | Hoboken, N. J. : John Wiley & Sons, c2007 |
| Descrizione fisica | xii, 254 p. : ill. (some col.) ; 26 cm |
| Disciplina | 615.1 |
| Altri autori (Persone) |
Czakâo, Barbara
Kèurti, Lâaszlâo |
| Soggetto topico |
Drugs
Molecular biology Pharmaceutical Preparations Molecular Biology - Methods |
| ISBN | 9780470227497 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNISALENTO-991002380249707536 |
|
Corey, E. J.
|
||
| Hoboken, N. J. : John Wiley & Sons, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. del Salento | ||
| ||
Molecules Engineered Against Oncogenic Proteins and Cancer : Discovery, Design, and Development
| Molecules Engineered Against Oncogenic Proteins and Cancer : Discovery, Design, and Development |
| Autore | Corey E. J |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Newark : , : John Wiley & Sons, Incorporated, , 2023 |
| Descrizione fisica | 1 online resource (391 pages) |
| Altri autori (Persone) | WuYong-Jin |
| ISBN |
1-394-20714-X
1-394-20709-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1. Introduction -- 1.1 Types of Protein Kinases -- 1.2 Protein Kinase Domains -- 1.3 ATP-Binding Site -- 1.4 Types of Kinase Inhibitors -- 1.5 Brief History of Small-molecule kinase Inhibitors -- 1.6 Peak 12-Month Sales for Leading Kinase Inhibitors -- 1.7 Approved Kinase Inhibitors -- Chapter 2. BCR-ABL Inhibitors -- 2.1 Imatinib* -- 2.2 Nilotinib* -- 2.3 Dasatinib* -- 2.4 Bosutinib* -- 2.5 Ponatinib* -- 2.6 Olvermbatinib** -- 2.7 Asciminib* -- Chapter 3. BTK Inhibitors -- 3.1 Ibrutinib* -- 3.2 Acalabrutinib* -- 3.3 Zanubrutinib* -- 3.4 Tirabrutinib** -- 3.5 Orelabrutinib** -- Chapter 4. EGFR/HER Family Inhibitors -- 4.1 Gefitinib* -- 4.2 Erlotinib * -- 4.3 Icotinib** -- 4.4 Afatinib* -- 4.5 Dacomitinib* -- 4.6 Osimertinib* -- 4.7 Mobocertinib* -- 4.8 Lapatinib* -- 4.9 Tucatinib* -- 4.10 Neratinib* -- Chapter 5. VEGFR/Multikinase Inhibitors -- 5.1 Sorafenib* -- 5.2 Regorafenib* -- 5.3 Sunitinib* -- 5.4 Pazopanib* -- 5.5 Axitinib* -- 5.6 Nintedanib* -- 5.7 Apatinib** -- 5.8 Lenvatinib* -- 5.9 Tovozanib* -- Chapter 6. CDK4/6 Inhibitors -- 6.1 Palbociclib* -- 6.2 Ribociclib* -- 6.3 Abemaciclib* -- 6.4 Trilaciclib* -- Chapter 7. JAK Inhibitors -- 7.1 Tofacitinib* -- 7.2 Baricitinib* -- 7.3 Peficitinib** -- 7.4 Upadacitinib* -- 7.5 Delgocitinib** -- 7.6 Filgotinib** -- 7.7 Abrocitinib* -- 7.8 Ruxolitinib* -- 7.9 Fedratinib* -- 7.10 Pacritinib* -- 7.11 Ritlecitinib# -- 7.12 Brepocitinib# -- 7.13 Ropsacitinib# -- Chapter 8. Allosteric TYK2 Inhibitors -- 8.1 Deucravacitinib* -- Chapter 9. ALK/multikinase Inhibitors -- 9.1 Crizotinib* -- 9.2 Ceritinib* -- 9.3 Alectinib* -- 9.4 Brigatinib* -- 9.5 Lorlatinib* -- Chapter 10. BRAF/Multikinase Inhibitors -- 10.1 Vemurafenib* -- 10.2 Dabrafenib* -- 10.3 Encorafenib* -- Chapter 11. MEK Inhibitors -- 11.1 Trametinib* -- 11.2 Cobimetinib*.
11.3 Binimetinib* -- 11.4 Selumetinib* -- Chapter 12. RET/Multikinase Inhibitors -- 12.1 Vandetanib* -- 12.2 Cabozantinib* -- 12.3 Selpercatinib* -- 12.4 Pralsetinib* -- Chapter 13. FGFR Inhibitors -- 13.1 Erdafitinib* -- 13.2 Pemigatinib* -- 13.3 Infigratinib* -- 13.4 Futibatinib* -- Chapter 14. PI3K Inhibitors -- 14.1 Alpelisib* -- 14.2 Idelalisib* -- 14.3 Duvelisib* -- 14.4 Umbralisib* -- 14.5 Copanlisib* -- Chapter 15. TRK/Multikinase Inhibitors -- 15.1 Larotrectinib* -- 15.2 Entrectinib* -- 15.3 Repotrectinib# -- Chapter 16. MET Inhibitors -- 16.1 Capmatinib* -- 16.2 Tepotinib* -- Chapter 17. KIT/PDGFR/Multkinase Inhibitors -- 17.1 Avapritinib* -- 17.2 Ripretinib* -- Chapter 18. FLT3 Inhibitors -- 18.1 Midostaurin* -- 18.2 Gilteritinib* -- Chapter 19. mTOR Inhibitors -- 19.1 Sirolimus* and Analogs -- Chapter 20. Other Kinase Inhibitors -- 20.1 Netarsudil* -- 20.2 Belumosudil* -- 20.3 Fostamatinib* -- 20.4 Pexidartinib* -- Chapter 21. KRAS Inhibitors -- 21.1 Sotorasib* -- 21.2 Adagrasib* -- 21.3 JDQ443# -- Chapter 22. An Overview of the Discovery Process for Medically Useful Inhibitors of Oncogenic Protein Kinases -- 22.1 High-quality Leads -- 22.2 Integrating Substructures from Different High Quality Leads or Established Inhibitors -- 22.3 Variation of Hinge-binding Nucleus -- 22.4 Macrocyclization -- 22.5 Fragment-based Approach -- 22.6 Covalent Inhibitors -- 22.7 Strategic Structural Modification of Prior Drugs -- 22.8 Exploiting Specific Kinase Pocket to Optimize Selectivity -- 22.9 Solvent-exposed Appendages to Enhance Solubility and PK Properties -- Chapter 23. Targeted Molecular Anticancer Therapies - Successes and Challenges -- 23.1 The Beginning -- 23.2 Further Developments -- 23.3 Biomarker-driven Drug Development -- 23.4 Mitigation of Drug Resistance -- 23.5 Miscellaneous Approaches -- 23.6 Discovery Chemistry. Appendix 1. First FDA Approvals by Year -- Appendix 2. Kinase/KRAS Inhibitors in Development -- Appendix 3. Visualization of Differentially Expressed Kinases in Cancer -- Appendix 4. M & -- A Transactions Driven by Oncology-focused Kinase and KRAS Inhibitors -- Appendix 5. Alphabetic List of Oncogenic Protein Inhibitors -- EULA. |
| Record Nr. | UNINA-9910746901003321 |
|
Corey E. J
|
||
| Newark : , : John Wiley & Sons, Incorporated, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Name reactions for carbocyclic ring formations [[electronic resource] /] / edited by Jie Jack Li ; foreword by E.J. Corey
| Name reactions for carbocyclic ring formations [[electronic resource] /] / edited by Jie Jack Li ; foreword by E.J. Corey |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley, c2010 |
| Descrizione fisica | 1 online resource (774 p.) |
| Disciplina | 547/.2 |
| Altri autori (Persone) |
LiJie Jack
CoreyE. J |
| Collana | Wiley series on comprehensive name reactions |
| Soggetto topico | Ring formation (Chemistry) |
| ISBN |
1-299-31411-2
0-470-87221-7 0-470-87220-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Name Reactions for Carbocyclic Ring Formations; Contents; Foreword; Preface; Contributing Authors; Chapter 1 Three-Membered Carbocycles; 1.1 Freund Reaction; 1.2 Kishner Cyclopropane Synthesis; 1.3 Kulinovich Cyclopropanol Synthesis; 1.4 Simmons-Smith Cyclopropanation; Chapter 2 Four-Membered Carbocycles; 2.1 Staudinger Ketene Cycloaddition; Chapter 3 Five-Membered Carbocycles; 3.1 Danheiser Annulation; 3.2 Dieckmann Condensation; 3.3 Favorskii Rearrangement; 3.4 Nazarov Cyclization; 3.5 Pauson-Khand Reaction; 3.6 Weiss-Cook Reaction; Chapter 4 Six-Membered Carbocycles
4.1 Bardhan-Sengupta Pheantherene Synthesis4.2 Bergman Cyclization; 4.3 Bogert-Cook Reaction; 4.4 Bradsher Cycloaddition and Bradsher Reaction; 4.5 Bradsher Reaction; 4.6 Darzens Synthesis of Tetralin Derivatives; 4.7 Diels-Alder Reaction; 4.8 Dötz Benzannulation; 4.9 Elbs Reaction; 4.10 Fujimoto-Belleau Reaction; 4.11 Haworth Reaction; 4.12 Moore Cyclization; 4.13 Myers-Saito Cyclization; 4.14 Robinson Annulation; 4.15 Scholl Reaction; Chapter 5 Large-Ring Carbocycles; 5.1 Buchner Reaction; 5.2 de Mayo Reaction; 5.3 Ring-closing Metathesis (RCM); 5.4 Thorpe-Ziegler Reaction Chapter 6 Transformations of Carbocycles 6.1 Blanc Chloromethylation Reaction; 6.2 Asymmetric Friedel-Crafts Reactions: Past to Present; 6.3 Houben-Hoesch Reaction; 6.4 Kolbe-Schmitt Reaction; 6.5 Vilsmeier-Haack Reaction; 6.6 von Richter Reaction; Appendices; 1, Contents Volume 1: Name Reactions in Heterocyclic Chemistry; 2, Contents Volume 2: Name Reactions for Functional Group Transformations; 3, Contents Volume 3: Name Reactions for Homologations-Part I; 4, Contents Volume 4: Name Reactions for Homologations-Part II; 5, Contents Volume 6: Name Reactions in Heterocyclic Chemistry-Part II Subject Index |
| Record Nr. | UNINA-9910140873403321 |
| Hoboken, N.J., : Wiley, c2010 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Name reactions for functional group transformations [[electronic resource] /] / edited by Jie Jack Li, E.J. Corey
| Name reactions for functional group transformations [[electronic resource] /] / edited by Jie Jack Li, E.J. Corey |
| Pubbl/distr/stampa | Hoboken, N.J., : Wiley-Interscience, c2007 |
| Descrizione fisica | 1 online resource (769 p.) |
| Disciplina |
547
547/.2 |
| Altri autori (Persone) |
LiJie Jack
CoreyE. J |
| Collana | Comprehensive Name Reactions |
| Soggetto topico |
Organic compounds - Synthesis
Chemical reactions |
| Soggetto genere / forma | Electronic books. |
| ISBN |
1-280-93539-1
9786610935390 0-470-17651-2 0-470-17650-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Asymmetric synthesis. CBS reduction ; Davis chiral oxaziridine reagents ; Midland reduction ; Noyori catalytic asymmetric hydrogenation ; Sharpless asymmetric hydroxylation reactions -- Reduction. Eschweiler-Clark reductive alkylation of amines ; Gribble reduction of diaryl ketones ; Luche reduction ; Meerwein-Ponndorf-Verley reduction ; Staudinger reaction ; Wharton reaction -- Oxidation. Baeyer-Villiger oxidation ; Brown hydroboration reaction ; Burgess dehydrating reagent ; Corey-Kim oxidation ; Dess-Martin periodinane oxidation ; Tamao-Kumada-Fleming oxidation ; Martin's sulfurane dehydrating reagent ; Oppenauer oxidation ; Prilezhaev reaction ; Rubottom oxidation ; Swern oxidation ; Wacker-Tsuji oxidation ; Woodward cis-dihydroxylation --
Olefination. Chugaev elimination ; Cope elimination reaction ; Corey-Winter olefin synthesis ; Perkin reaction (cinnamic acid synthesis) ; Perkow vinyl phosphate synthesis ; Ramberg-Bäcklund olefin synthesis ; Shapiro reaction ; Zaitsev elimination -- Amine synthesis. Fukuyama amine synthesis ; Gabriel synthesis ; Leuckart-Wallach reaction -- Carboxylic acid derivatives synthesis. Fischer-Speier esterification ; Mukaiyama esterification ; Ritter reaction ; Strecker amino acid synthesis ; Yamada coupling reagent ; Yamaguchi esterification -- Miscellaneous functional group manipulations. Balz-Schiemann reaction ; Buchwald-Hartwig reactions ; Haloform reaction ; Hunsdiecker reaction ; Japp-Klingemann hydrazone synthesis ; Krapcho decarboxylation ; Nef reaction ; Prins reaction ; Regitz diazo synthesis ; Sommelet reaction. |
| Record Nr. | UNINA-9910143425703321 |
| Hoboken, N.J., : Wiley-Interscience, c2007 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
