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Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression / / Lucy W. Barrett, Sue Fletcher, Steve D. Wilton



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Autore: Barrett Lucy W Visualizza persona
Titolo: Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression / / Lucy W. Barrett, Sue Fletcher, Steve D. Wilton Visualizza cluster
Pubblicazione: Basel, : Springer, 2013
Edizione: 1st ed. 2013.
Descrizione fisica: 1 online resource (63 p.)
Disciplina: 570
572.88
Soggetto topico: Gene expression
Genetic regulation
Altri autori: FletcherSue  
WiltonSteve D  
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references.
Nota di contenuto: Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
Sommario/riassunto: There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Titolo autorizzato: Untranslated gene regions and other non-coding elements  Visualizza cluster
ISBN: 3-0348-0679-5
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910437608003321
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Serie: SpringerBriefs in Biochemistry and Molecular Biology, . 2211-9353