The basics of molecular biology / / Alexander Vologodskii

• Autore: Vologodskiĭ A. V (Aleksandr Vadimovich)
• Pubblicazione: Cham, Switzerland : , : Springer International Publishing, , c2023; ©2022
• Descrizione fisica: 1 online resource (188 pages)
• Disciplina: 572.8
• Soggetto topico: Molecular biology; Molecular biology - Research
• Nota di contenuto: Intro -- Preface -- Recommended Literature -- Introduction -- Acknowledgments -- Contents -- Chapter 1: The Major Processes in the Biological World -- 1.1 Cells as Basic Units of Life -- 1.2 Important Facts from Chemistry and Physics -- 1.2.1 The Flexibility of Polymer Chains -- 1.2.2 Noncovalent Interactions Between Atoms -- 1.3 Structure of DNA and Inheritance of Genetic Information -- 1.3.1 The General Principles -- 1.3.2 Chemical Structure of DNA -- 1.3.3 The Double Helix -- 1.4 RNA Molecules -- 1.5 Proteins -- 1.5.1 The General Principles -- 1.5.2 Structure of Proteins -- 1.6 Genetic Code -- 1.7 From DNA to Proteins -- 1.8 Concluding Remarks -- Chapter 2: Enzymes, Conformational Changes, Energy, and Molecular Motors -- 2.1 The Motion of Macromolecules in Water -- 2.2 Enzymes -- 2.3 Conformational Flexibility of Proteins and Allosteric Transitions -- 2.4 The Energy in Cell Life -- 2.5 Molecular Motors -- 2.6 Energy Transfer from Food to ATP -- Chapter 3: The Cells -- 3.1 The Lipid Membrane -- 3.2 Membrane Proteins -- 3.2.1 General View -- 3.2.2 Channels -- 3.2.3 Osmotic Pressure -- 3.2.4 Transporters -- 3.3 Prokaryotic and Eukaryotic Cells -- 3.4 The Cell Cycle -- Chapter 4: Genome -- 4.1 Preliminary Remarks -- 4.2 Prokaryotic Genome -- 4.3 Eukaryotic Genome -- 4.3.1 RNA Splicing -- 4.3.2 Mobile Genetic Elements -- 4.4 Chromosomes -- 4.4.1 General Features of Eukaryotic Chromosomes -- 4.4.2 Nucleosomes and Epigenetic Inheritance -- 4.4.3 Higher Orders of Chromatin Structure -- 4.5 DNA Sequencing -- 4.6 Genome Editing -- 4.6.1 Plasmids and Genetic Engineering -- 4.6.2 CRISPR-Cas9 and Editing of Large Genomes -- Chapter 5: Regulation of Gene Expression and Protein Activity -- 5.1 Regulation of Transcription -- 5.1.1 Transcription Regulation in Prokaryotes -- 5.1.2 Eukaryotic Transcription -- 5.1.3 Cell Memory. ; 5.2 Posttranscriptional Changes of mRNAs -- 5.2.1 Degradation of mRNA -- 5.2.2 Alternative RNA Splicing -- 5.2.3 Editing of mRNA -- 5.3 Suppression of Gene Expression by Small Noncoding RNA Molecules -- Chapter 6: DNA Replication, Its Fidelity, Mutations, and Repair -- 6.1 Replication of the Double Helix -- 6.1.1 Directionality and Proofreading of DNA Synthesis -- 6.1.2 Replication of Leading and Lagging Strands -- 6.1.3 Telomeres and the Organism Aging -- 6.1.4 Replication Complex and Epigenetic Inheritance -- 6.2 DNA Damage and Repair -- 6.3 Evolution of Species -- 6.3.1 The Theory of Evolution -- 6.3.2 The Evolution Tree -- 6.3.3 Conserved Regions of Eukaryotic Genomes -- 6.3.4 Genomes and the Human History -- 6.4 Accumulation of Mutations in Human Individuals and Populations -- 6.4.1 Mutations in Somatic Cells -- 6.4.2 Mutations in Germ Cells and the Age of Parents -- 6.4.3 Tracing the Past and Predicting the Future -- Chapter 7: Transduction of Signals -- 7.1 The General Principle -- 7.2 How Receptors Receive Signal Molecules -- 7.3 Intracellular Signaling Molecules -- 7.4 G-Protein-Coupled Receptors -- 7.5 Signal Transduction in Neurons -- 7.5.1 Electrical Properties of the Membrane -- 7.5.2 The Action Potential -- 7.6 Sensing Smell -- Chapter 8: Multicellular Organisms and Their Development -- 8.1 Body Tissues and Connections Between the Cells -- 8.2 Development of Multicellular Organisms -- 8.2.1 The Basic Mechanism of the Development -- 8.2.2 Differentiation of Cells in the Development of the Organism -- 8.2.3 Morphogenesis -- 8.2.4 Sizing and Timing -- 8.3 Stem Cells -- 8.3.1 General Properties of the Stem Cells -- 8.3.2 Blood Regeneration -- 8.3.3 Embryonic and Induced Pluripotent Stem Cells -- 8.4 Death of the Cells -- 8.4.1 Basic Steps of Apoptosis -- 8.4.2 Apoptotic Signaling Chains. ; Chapter 9: Biological Defense I: Protection from Foreign Nucleic Acids -- 9.1 General Remarks -- 9.2 The Restriction-Modification System -- 9.3 CRISPR-Cas System -- 9.4 RNA-Induced Silencing Complexes -- Chapter 10: Biological Defense II: The Immune Systems of Vertebrates -- 10.1 The Adaptive Immune System -- 10.1.1 B Cells -- 10.1.2 Antibodies -- 10.1.3 T Cells -- 10.2 The Innate Immune System -- 10.2.1 Epithelium and Defensins -- 10.2.2 Phagocytic Cells -- 10.2.3 Antiviral Defense -- 10.2.4 Natural Killer Cells -- 10.2.5 Dendritic Cells -- Chapter 11: Pathogens -- 11.1 Viruses -- 11.1.1 General Properties -- 11.1.2 RNA Viruses -- 11.1.3 Evolution of Viruses -- 11.1.4 Prevention and Cure -- 11.2 Bacteria -- 11.2.1 Invading into a Human Body -- 11.2.2 Pathogenesis -- 11.2.3 Antibiotics -- 11.3 Eukaryotic Parasites -- Chapter 12: Cancer -- 12.1 General Remarks -- 12.2 Basic Features of Cancer -- 12.3 Cancer-Critical Genes -- 12.3.1 Two Types of Genes Are Critical for the Disease Development -- 12.3.2 Changes in Regulatory Pathways -- 12.4 External Causes of Cancers -- 12.4.1 Carcinogens -- 12.4.2 Lifestyle -- 12.4.3 Viruses and Other Pathogens -- 12.5 Cures of Cancers -- 12.5.1 Inhibiting of Proteins Crucial for Cancer Development -- 12.5.2 Immunotherapy of Cancer -- 12.5.3 Multidrug Therapy -- Glossary -- Index.
• Titolo autorizzato: The basics of molecular biology
• ISBN: 9783031194047; 9783031194030
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910634040803321
• Lo trovi qui: Univ. Federico II