Spatiotemporal Modeling of Cancer Immunotherapy : Partial Differential Equation Analysis in R / / by William E. Schiesser
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| Autore: |
Schiesser W. E.
|
| Titolo: |
Spatiotemporal Modeling of Cancer Immunotherapy : Partial Differential Equation Analysis in R / / by William E. Schiesser
|
| Pubblicazione: | Cham : , : Springer International Publishing : , : Imprint : Springer, , 2019 |
| Edizione: | 1st ed. 2019. |
| Descrizione fisica: | 1 online resource (116 pages) : illustrations |
| Disciplina: | 515.353 |
| Soggetto topico: | Biomedical engineering |
| Mathematical models | |
| Cancer - Research | |
| R (Computer program language) | |
| Biomedical Engineering/Biotechnology | |
| Mathematical Modeling and Industrial Mathematics | |
| Cancer Research | |
| Biomedical Engineering and Bioengineering | |
| Nota di contenuto: | Fixed Boundary PDE Model Formulation -- Fixed Boundary PDE Model Implementation -- Fixed Boundary PDE Model Output -- Moving Boundary PDE Model Implementation -- Moving Boundary PDE Model Output -- Index. |
| Sommario/riassunto: | The focus of this book is a detailed discussion of a dual cancer vaccine (CV)-immune checkpoint inhibitor (ICI) mathematical model formulated as a system of partial differential equations (PDEs) defining the spatiotemporal distribution of cells and biochemicals during tumor growth. A computer implementation of the model is discussed in detail for the quantitative evaluation of CV-ICI therapy. The coding (programming) consists of a series of routines in R, a quality, open-source scientific computing system that is readily available from the internet. The routines are based on the method of lines (MOL), a general PDE algorithm that can be executed on modest computers within the basic R system. The reader can download and use the routines to confirm the model solutions reported in the book, then experiment with the model by varying the parameters and modifying/extending the equations, and even studying alternative models with the PDE methodology demonstrated by the CV-ICI model. Spatiotemporal Modeling of Cancer Immunotherapy: Partial Differential Equation Analysis in R facilitates the use of the model, and more generally, computer- based analysis of cancer immunotherapy mathematical models, as a step toward the development and quantitative evaluation of the immunotherapy approach to the treatment of cancer. |
| Titolo autorizzato: | Spatiotemporal Modeling of Cancer Immunotherapy |
| ISBN: | 3-030-19080-3 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910337938503321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |