Protein conformation

• Pubblicazione: Chichester [England] ; ; New York, : Wiley, 1991
• Descrizione fisica: 1 online resource (288 p.)
• Disciplina: 574.19/245
• Soggetto topico: Proteins - Conformation
• Note generali: Proceedings of the Symposium on Protein Conformation, held Jan. 22-24, 1991 at the Ciba Foundation, London, England.; "A Wiley-Interscience publication".
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: PROTEIN CONFORMATION; Contents; Introduction; Mechanisms of enzyme catalysis from crystal structure analyses; Comparative analysis of protein three-dimensional structures and an approach to the inverse folding problem; Structural and genetic analysis of electrostatic and other interactions in bacteriophage T4 lysozyme; Simulation analysis of the stability mutants R96H of bacteriophage T4 lysozyme and I96A of barnase; Towards time-resolved diffraction studies with glycogen phosphorylase ; The application of computational methods to the study of enzyme catalysis by triose-phosphate isomerase and stabilities of variants of bacteriophage T4 lysozymeMultidimensional triple resonance NMR spectroscopy of isotopically uniformly enriched proteins: a powerful new strategy for structure determination; Six years of protein structure determination by NMR spectroscopy: what have we learned?; On deriving spatial protein structure from NMR or X-ray diffraction data; NMR spectroscopy and protein folding: studies of lysozyme and a-lactalbumin ; Experimental studies of pathways of protein foldingProtein stability and protein folding; Ca2+ binding in proteins of the calmodulin superfamily: cooperativity, electrostatic contributions and molecular mechanisms; Protein-protein interaction: an analysis by computer simulation; General discussion; Index of contributors; Subject index
• Sommario/riassunto: How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.
• Titolo autorizzato: Protein conformation
• ISBN: 1-282-34774-8; 9786612347740; 0-470-51414-0; 0-470-51415-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910876503203321
• Lo trovi qui: Univ. Federico II
• Serie: Ciba Foundation symposium ; ; 161.