Oral bioavailability assessment : basics and strategies for drug discovery and development / / Ayman F. El-Kattan

• Autore: El-Kattan Ayman F.
• Pubblicazione: Hoboken, New Jersey : , : Wiley Blackwell, , 2017; ©2017
• Descrizione fisica: 1 online resource (455 pages) : illustrations
• Disciplina: 615.1/9
• Soggetto topico: Dental pharmacology
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
• Titolo autorizzato: Oral bioavailability assessment
• ISBN: 1-118-91693-X; 1-118-91694-8; 1-118-91692-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910809803503321
• Lo trovi qui: Univ. Federico II