Nanotechnology in Therapeutics : Basics and Trends

• Autore: Demetzos Costas
• Pubblicazione: Newark : , : John Wiley & Sons, Incorporated, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (303 pages)
• Disciplina: 615/.6
• Soggetto topico: Nanomedicine; Nanoparticles
• Altri autori: DouroumisDennis SnowdenMartin J FahrAlfred SiepmannJuergen TorchilinVladimir P
• Nota di contenuto: Cover -- Series Page -- Title Page -- Copyright Page -- Dedication Page -- Contents -- About the Author -- Foreword -- Advances in Pharmaceutical Technology: Series Preface -- Preface -- Acknowledgments -- List of Abbreviations -- List of Figures -- List of Tables -- Part A Nanotechnology: Introduction and Brief Historical Overview -- Chapter 1 Introduction and Applications of Nanotechnology -- 1.1 Nanotechnology: Introduction and Brief Historical Overview -- 1.2 An Overview of Nanomedicines -- 1.3 Nanomedicine -- 1.4 The Strategic Research and Innovation Agenda for anomedicine (SRIA) 2016-2030 (www.etp-nanomedicine.eu) -- References -- Chapter 2 Biophysics, Thermodynamics, and Stability of Colloidal Dispersion Nanosystems -- 2.1 The Eukaryotic Cell Membranes -- 2.1.1 Structure and Function of Cell Membranes -- 2.1.2 Thermodynamic Properties of the Lipid Bilayers of Cell Membranes -- 2.2 Liquid Crystals (LCs) -- 2.2.1 Thermotropic and Lyotropic Liquid Crystals -- 2.3 Liquid Crystals in Biological Systems -- 2.4 The Role of Lipidic Domains in Cell Membranes -- 2.4.1 Lipid Conformational and Motional Properties -- 2.5 Dispersion Nanosystems -- 2.6 Stability of Nanocolloidal Dispersion Systems -- 2.6.1 Fundamentals of DLVO Theory -- 2.7 The DLVO Theory -- 2.7.1 Historical Background in Brief -- 2.7.2 Extension of the Classic DLVO Theory -- 2.7.3 Classification of Hydration Forces During the Interaction of Nanoparticles of a Colloidal Dispersion System -- 2.7.4 Entropic Effect -- 2.7.5 Osmotic Effect -- 2.7.6 Enthalpic Stabilization -- 2.8 Introduction to Applied Thermodynamics and Biothermodynamics -- 2.8.1 Introduction to Thermodynamics -- 2.8.2 Small System Thermodynamics -- 2.8.3 Comparison of Thermal Analysis with Other Analytical Techniques -- 2.8.4 Classification of Thermal Analysis Techniques. ; 2.8.5 Differential Scanning Calorimetry: Basic Principles -- 2.8.6 Polymorphism - Lyotropism -- 2.8.7 Differential Scanning Calorimetry (DSC) Types -- 2.9 Light Scattering Techniques -- 2.9.1 Photon Correlation Spectroscopy (PCS) -- 2.10 Microscopy -- 2.10.1 Optical Microscopy -- 2.10.2 Electron Microscopy -- 2.10.3 Scanning Probe Microscopy -- References -- Part B Lipid and Polymeric Nanostructures in Medicine -- Chapter 3 Liposomes: An Overview -- 3.1 Introduction and Historical Issues of Liposomal Technology -- 3.2 Types of Liposomes -- 3.3 Entrapment of Bioactive Molecules in Multilamellar Lipid Vesicles and Liposomes -- 3.4 Advantages of Liposomes -- 3.5 Liposomes as Model of the Cell Membrane and Properties of Their Liquid Crystalline State of Matter -- 3.6 Liposome Physicochemical Characterization and Their Physical Stability -- 3.6.1 Summary of Liposome Preparation Methods -- 3.7 Liposomes as Analytical Tool -- 3.7.1 Biosensors Based on Liposome Technology -- 3.7.2 Future Perspectives in Lipidic Drug Delivery Nanosystems -- References -- Chapter 4 Lipidic and Polymeric Nanomedicines in Clinical Applications -- 4.1 Liposomal Nanomedicines -- 4.1.1 Anticancer Liposomal Medicines -- 4.1.2 Antifungal Liposomal and Lipidic-based Nanomedicines. Case Study of Liposomal and Lipidic-based Amphotericin B -- 4.1.3 Lipid Nanoparticles -- 4.2 Advanced Liposomal Nanomedicines -- 4.2.1 Stimuli-responsive Liposomal Nanosystems -- 4.2.2 Immunoliposomes -- 4.2.3 Mitochondria as Target Domain -- 4.3 Polymers -- 4.3.1 Polyelectrolytes -- 4.4 Polymersomes -- 4.4.1 Polymersome Size and Size Distribution Evaluation -- 4.4.2 Polymersome Properties and Applications -- 4.4.3 Polymersome Surface Chemistry -- 4.4.4 Polymerosome Applications -- 4.5 Biodegradable Polymeric Nanoparticles -- 4.6 Polymeric Micelles -- 4.7 Dendrimers -- 4.7.1 Dendrimer Use in Biomedicine. ; 4.7.2 Dendrimer Applications -- 4.7.3 Dendrimer Application in Diagnostics with Magnetic Resonance Imaging Technique -- References -- Chapter 5 Applied Nanotechnology -- 5.1 Nanotechnology in Therapeutics -- 5.2 Nanotechnology and Cancer -- 5.3 Nanooncology and Gene Transfer -- 5.4 Nanobiotechnology -- 5.5 Nanogenomics and Nanoproteomics -- 5.6 Delivery Nanosystems for Therapeutic Biological Products -- 5.7 New Therapies Based on Nanotechnology -- 5.8 Theranostics -- 5.8.1 Theranostics: Applications in the Treatment, Diagnosis of Diseases, and Tissue Monitoring -- References -- Chapter 6 Nanotechnology in Vaccines -- 6.1 Introduction to Vaccines -- 6.2 Development of Novel Nanovaccines -- 6.3 Liposomes, Lipid Nanoparticles, and Nonviral Lipid Nanoparticles (Virosomes) -- 6.4 Vaccines Against SARS‐CoV‐2 Virus -- 6.4.1 Stability of Nanovaccines as Nanocolloids -- 6.5 Future Perspectives and the Concept of the "Thermodynamic Epitope" -- 6.6 LNPs‐based Nanovaccines in Clinical Applications -- 6.6.1 Comirnaty® -- 6.6.2 Spikevax -- References -- Part C Nanotechnology and Nanomedicine: The Regulatory Landscape -- Chapter 7 New Health Technologies and Regulatory Approaches -- 7.1 New Health Technologies and the Regulatory Landscape for the Approval Process -- 7.2 Nanoinformatics -- 7.2.1 Artificial Intelligence (AI) -- 7.3 Complex Systems, Complexity, and Artificial Bionanosystems -- 7.4 Chaos and Nonlinear Dynamics in Nanocolloids -- 7.4.1 Chaotic Dynamic Systems -- 7.4.2 Lyapunov Approximation -- 7.4.3 Linking Lyapunov Exponents to Information -- 7.5 Nanocolloids. Complexity, Chaos, and Stability -- 7.6 Regulatory Agencies -- 7.6.1 Medicine Approval Processes -- 7.7 Advanced Therapy Medicinal Products (ATMPs) -- 7.8 Approval Process for Advanced Therapy Medicinal Products. ; 7.9 The Regulatory Framework for the Nanobiotechnological Products in the United States and the Role of the FDA -- 7.10 Regulatory Issues for Biotechnological Medicines. The Role of the EMA -- 7.11 Committee for Advanced Therapies (CAT) -- 7.12 Nanosimilars -- 7.13 Generics and Biosimilar Therapeutic Products -- References -- Index -- EULA.
• Sommario/riassunto: "Nanotechnology delivers a unique approach, which promises higher drug efficacy, targeted drug delivery, on demand delivery, biocompatibility, etc. For example, nanotechnology-based delivery systems can protect drugs from degradation and help reduce the number of doses required, make treatment a better experience and reduce treatment expenses and a number of nano-based systems allow delivery of insoluble drugs, allowing the use of previously rejected drugs or drugs which are difficult to administer. Market description (Please include secondary markets)"--
• Titolo autorizzato: Nanotechnology in Therapeutics
• ISBN: 1-394-27408-4; 1-394-27406-8
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910878995403321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Pharmaceutical Technology Series