Metal ions and neurodegenerative disorders / / editor, Paolo Zatta

• Pubblicazione: New Jersey, : World Scientific, c2003
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (538 p.)
• Disciplina: 616.80471
• Soggetto topico: Metal ions - Physiological effect; Molecular neurobiology; Nervous system - Degeneration; Neurotoxicology
• Altri autori: ZattaPaolo
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Contents ; Preface ; List of Contributors ; Chapter 1. Metal-Catalyzed Redox Activity in Neurodegenerative Disease ; 1. INTRODUCTION ; 1.1. Redox-Active Transition Metals in AD ; 1.2. Aggregation of Amyloid-B and Amyloid B Protein Precursor/Amyloid-p-Linked ROS Production ; 1.3. Iron in Neurodegenerative Disease 1.4. Iron-Mediated Oxidative Stress in Parkinson's Disease ; 1.5. Manganese and Parkinson's Disease ; 1.6. Antioxidant and Transition Metal Homeostasis ; 1.7. CuZnSOD Mutations and Familial Amyotrophic Lateral Sclerosis ; 2. CONCLUSIONS ; Chapter 2. Metals Distribution and Regionalization in the Brain 1. TRACE ELEMENT DISTRIBUTION IN NORMAL HUMAN BRAIN ; 1.1. Aluminum Iron Copper and Zinc Distribution in Normal Human Brain Sites in Relation to Age ; 1.2. Aluminum ; 1.3. Iron ; 1.4. Copper ; 1.5. Zinc ; 2. TRACE ELEMENT IMBALANCES IN NEURODEGENERATIVE DISEASES 2.1. Aluminum Iron Copper and Zinc in Alzheimer's Disease ; 2.2. Factors Affecting the Final Results ; 2.3. Aluminum Iron Copper and Zinc in Parkinson's Disease ; 2.4. Aluminum Iron Copper and Zinc in Western Pacific Parkinsonism-Dementia 2.5. Aluminum Iron Copper and Zinc in Amyotrophic Lateral Sclerosis ; 3. FINAL REMARKS ; Chapter 3. The Olfactory Pathway as a Route of Entry of Metals into the Brain ; 1. INTRODUCTION ; 2. ANATOMY OF THE OLFACTORY SYSTEM
• Sommario/riassunto: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences
• Titolo autorizzato: Metal ions and neurodegenerative disorders
• ISBN: 1-281-95608-2; 9786611956080; 981-279-669-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910814637303321
• Lo trovi qui: Univ. Federico II