Metabolic Syndrome : A Comprehensive Textbook

• Autore: Ahima Rexford S
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2023
• Edizione: 2nd ed.
• Descrizione fisica: 1 online resource (813 pages)
• Disciplina: 616.398
• Soggetto topico: Metabolic syndrome; Obesity
• Nota di contenuto: Intro -- Preface to the Second Edition -- Preface to the First Edition -- Acknowledgments -- Contents -- About the Editor -- Contributors -- Part I: Epidemiology -- 1 Overview of Metabolic Syndrome -- References -- 2 Obesity and Metabolic Syndrome in the United States -- Introduction -- Epidemiology of Obesity and Metabolic Syndrome in the United States -- Historical Trends in Obesity -- Current Obesity Burden -- Trends in Metabolic Syndrome -- Sociodemographic/Geographic Correlates -- Race/Ethnic Differences -- Environmental/Behavioral Factors -- Behavioral Factors -- Socioeconomic Factors -- Childhood Obesity -- Health Implications and Diseases Associated with Rising Obesity Trends -- Obesity Management -- Lifestyle Modification -- Motivational Interviewing -- Pharmacotherapy for Obesity -- Bariatric Surgery -- Conclusion -- References -- 3 Obesity and Metabolic Syndrome in Latin America -- Introduction -- Characteristics and Metabolic Risk Factors in the Latin American Population -- Epidemiology of Obesity -- Obesity Trends in Latin American Children and Adolescents -- Epidemiology of Metabolic Syndrome -- Metabolic Syndrome Components -- Obesity -- Impaired Fasting Glucose, Glucose Intolerance, Prediabetes, and Diabetes -- Dyslipidemia -- Hypertension -- Regional Strategies Implemented and in Development -- Taxes on Sugar-Sweetened Beverages (SSBs) -- Front of Package Labels -- Food Marketing -- School Food Environment -- Physical Activity Interventions -- Conclusions -- References -- 4 Obesity in Africa: A Silent Public Health Crisis -- Introduction -- Measurement of Overweight and Obesity -- Prevalence of Overweight and Obesity in Africa -- Determinants of Obesity -- Urban and Rural Differences in Overweight and Obesity -- Sociodemographic Factors and Obesity -- Socioeconomic Status and Obesity. ; Regional Differences and Overweight prevalence -- Perceptions of Body Size and Obesity -- Lifestyle Factors and Overweight and Obesity -- Relationship Between Overweight and Obesity, and CVD and Diabetes in Africa -- Obesity Interventions in Sub-Saharan Africa -- Promotion of Physical Activity -- Nutrition and Diet-Related Policies -- Fiscal Policies to Promote Healthy Diets -- Discussion -- Conclusion -- References -- 5 Obesity in Middle East -- Introduction -- Evidence on Obesity in the Middle East and North Africa Region -- Evidence from Official Sources -- Evidence from the Literature -- Low-Income Countries -- Lower-Middle-Income Countries -- Upper-Middle-Income Countries -- High-Income Countries -- Child Obesity in the Middle East and North Africa Region - Most Recent Evidence from the Literature -- Child Obesity -- Correlates of Child Obesity -- Correlates of Obesity in Middle East and North Africa Region -- Gender -- Age -- Income and Socioeconomic Class -- Education -- Exercise/Activity -- Nutrition -- Fat Intake -- Fiber Intake -- Urbanization -- Obesity-Related Noncommunicable Diseases in the MENA Region -- Diabetes Prevalence in the MENA Region -- Evidence from Official Sources -- Evidence from the Literature -- Association between Diabetes and Excess Weight in the MENA Region -- Cardiovascular Disease and Hypertension -- Hypertension -- Evidence from Official Sources -- Evidence from the Literature -- Cardiovascular Disease -- Chronic Kidney Disease -- Cancer -- Conclusion -- References -- 6 Obesity and Metabolic Syndrome in South Asians -- Introduction -- Metabolic Syndrome Definition and Epidemiology in South Asians -- Definition -- Epidemiology -- Pathophysiology of the Metabolic Syndrome in South Asians -- Obesity and Central Adiposity -- Dyslipidemia -- Hypertension -- Hyperglycemia and Insulin Resistance in South Asians. ; Urbanization, Migration, and Acculturation -- Diabetes and Metabolic Syndrome in South Asians -- Cardiovascular Disease and Metabolic Syndrome in South Asians -- Therapeutic Approaches for Metabolic Syndrome in South Asians -- Conclusion -- References -- 7 Obesity in East Asia -- Introduction -- Prevalence and Trends of Obesity in East Asia -- General and Abdominal Obesity in Adults -- China -- Japan -- South Korea -- Taiwan -- General Obesity in Children -- Metabolic Health and Obesity in East Asia -- Epidemiological and Clinical Implications of the MONW Phenotype -- Epidemiological and Clinical Implications of the MHO Phenotype -- Conclusions -- References -- Part II: Genetic Factors -- 8 Evolution of Obesity -- Introduction -- Why Do Animals and Humans Have Adipose Tissue? -- Why Do We Get Obese? -- Adaptive Interpretations of Obesity -- The Neutral Viewpoint -- The Maladaptive Scenario -- Conclusion -- Cross-References -- References -- 9 Genetics of Type 2 Diabetes -- Introduction -- Candidate Gene and Family-Based Studies -- Genome-Wide Association Studies (GWAS) -- T2D Risk Prediction -- Sequencing Efforts: Missense Variants -- GWAS Outcomes for Obesity -- Functional Follow-Up of GWAS-Implicated Loci -- Causal Variant -- Causal Tissue -- TCF7L2 -- Pancreatic Islet -- Liver -- Gastrointestinal Tract -- Adipose Tissue -- Connection to Cancer -- FTO -- Causal Gene -- Genetics of Early Life: Implications for T2D in Later Life -- LADA: A Major Confounder in Genetic Studies of T2D -- Conclusion -- References -- 10 Genetics of Lipid Disorders -- Introduction -- Genetics of HDL-C -- Variation in Genes Involved in HDL-C Synthesis and Metabolism -- Variation in Genes Involved in HDL-C Transport and Binding -- Variation in Genes Involved in Cell Proliferation, Inflammation, and Related Pathways. ; Genetic Variants Associated with HDL-C Identified Through GWAS -- Genetics of LDL-C -- Genetic Variation in Enzymes, Receptors and Transporters, and LDL-C -- Genetic Variation in Lipoproteins and LDL-C -- Genetic Variation in Proteases and LDL-C Levels -- Genetic Variation in Inflammatory and Immune Systems and LDL-C -- GWAS, Exome Sequencing, and LDL-C -- Genetics of Triglycerides (TG) -- Genetic Variation in Apolipoproteins and TG -- Genetic Variation in Enzymes and Transcription Factors and TG -- Genetic Variation in Storage and Inflammatory and Immune Systems and TG -- GWAS and TG -- Genetics of Dyslipidemia -- Genetics of Dyslipidemia Using More Complex Modeling Approaches -- Genetics of Dyslipidemia Using Genetic Risk Scores -- Genetics of Dyslipidemia Using Multi-Locus Burden and Dimension Reduction Methods -- Genetics of Dyslipidemia and MetSyn Using Causal Modeling and Pathway Approaches -- Pharmacogenomics for Dyslipidemia and MetSyn -- Cross-References -- References -- Part III: Environmental Factors -- 11 Diet and Obesity -- Introduction -- Popular Diets in the Lay Literature -- The Weight Loss Equation: Is Math Really That Simple? -- Factors Affecting Weight Loss -- Genetic Factors -- Physical Activity -- Insulin -- Hormones -- Food Supply -- Gut Microbiome -- Intermittent Fasting as a Tool to Change Metabolism -- Dietary Macronutrients -- Low-Carbohydrate and Ketogenic Diets: Metabolic Rationale -- Low-Fat and Very Low-Fat Diets: Metabolic Rationale -- The Mediterranean Diet: Rationale and Effects -- Randomized Controlled Dietary Interventional Trials with Different Diets -- Systematic Reviews and Meta-analyses -- Effects of Diet on Body Composition -- Conclusion -- References -- 12 The Built Environment and Metabolic Syndrome -- Introduction -- The Food Environment -- The Physical Activity Environment -- Combined Exposures. ; Methodological Notes -- Conclusion and Implications for Practice -- References -- 13 Social and Community Networks and Obesity -- Introduction -- Overview of Social and Community Networks -- Social Network Modeling -- Network Analysis in Epidemiology -- Mathematical Aspects of the Network Modeling -- The Obesity Transition Rule -- The Notion of Centrality in the Contagion Network -- Application to the Spread of Obesity -- Obesity Factors for Network Simulation for Public Health Policies and Prevention -- Environmental Factors -- Physical Factors -- Social Factors -- Social Network Analysis -- Psychological and Behavioral Factors -- Biological Factors -- Network Simulations -- Conclusion -- References -- Part IV: Pathophysiology -- 14 Principles of Energy Homeostasis -- Introduction -- Energy Intake -- Energy Expenditure -- Measurement of Energy Expenditure -- Energy Partitioning -- Hormones Mediating Energy Homeostasis -- Brown Adipose Thermogenesis -- Muscle Thermogenesis -- Energy Dysregulation in Obesity -- Conclusions -- Cross-References -- References -- 15 Carbohydrate, Protein, and Fat Metabolism in Obesity -- Introduction -- Macronutrient Intake Versus Oxidation in Obesity -- Carbohydrate Metabolism in Obesity -- Overview of Glucose Metabolism -- Glucose Uptake and Phosphorylation -- Glycolysis and Oxidation -- Glucose Storage -- Hepatic Glucose Production -- De Novo Lipogenesis -- Lipid Metabolism in Obesity -- Overview of Lipid Metabolism -- Fatty Acid Uptake -- Fatty Acid Oxidation -- Fatty Acid Turnover -- Consequences of Altered Tissue Lipid Balance in Obesity -- Protein Metabolism in Obesity -- Overview of Protein Metabolism -- Protein Turnover in Obesity -- Branched-Chain Amino Acids (BCAA) and Obesity -- Concluding Remarks -- References -- 16 Brain Regulation of Feeding and Energy Homeostasis -- Introduction. ; Sensing Metabolic Cues: Humoral and Neural Components.
• Sommario/riassunto: This comprehensive textbook, edited by Rexford S. Ahima, provides an in-depth examination of metabolic syndrome, highlighting its rising incidence and the associated health risks such as coronary artery disease, stroke, and various other conditions. The book serves as a valuable resource for clinicians, researchers, and students, offering insights into the epidemiology, genetics, environmental factors, and clinical management of obesity and metabolic syndrome. It covers a range of topics, including the obesity epidemic, its genetic and environmental influences, and the complex interplay between obesity and diseases like diabetes, cancer, and sleep disorders. The text aims to enhance the understanding and management of metabolic syndrome, addressing both scientific and clinical aspects, and is intended for a professional audience in the medical and health sciences fields.
• Titolo autorizzato: Metabolic Syndrome
• ISBN: 9783031401169; 3031401166
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910831002903321
• Lo trovi qui: Univ. Federico II