Immunology : A Short Course

• Autore: Coico Richard
• Pubblicazione: New York : , : John Wiley & Sons, Incorporated, , 2015; ©2014
• Edizione: 7th ed.
• Descrizione fisica: 1 online resource (433 pages)
• Disciplina: 616.07/9
• Soggetto topico: Immune System Processes
• Altri autori: SunshineGeoffrey
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Intro -- Title Page -- Copyright Page -- Contents in Brief -- Contents -- About the Authors -- Contributors -- Preface and Acknowledgments -- How to Use Your Textbook -- About the Companion Website -- Chapter 1 Overview of the Immune System -- Introduction -- Innate and Adaptive Immunity -- Innate Immunity -- Adaptive Immunity -- Clonal Selection Theory -- Active, Passive, and Adoptive Immunization -- Major Characteristics of the Adaptive Immune Response -- Cells Involved in the Adaptive Immune Response -- Humoral and Cellular Immunity -- Humoral Immunity -- Cell-Mediated Immunity -- Generation of Diversity in the Immune Response -- Benefits of Immunology -- Damaging Effects of the Immune Response -- The Future of Immunology -- The Short Course Begins Here -- References and Bibliography -- Chapter 2 Innate Immunity -- Introduction -- Physical and Chemical Barriers of Innate Immunity -- Origin, Differentiation, and Characterizationof Cells of the Innate Immune System -- Pattern Recognition: The Hallmark of Innate Immune Responses -- Pattern Recognition Receptors -- Complement -- Intracellular and Extracellular Killing of Microorganisms -- Inflammation -- Hallmark Signs of Inflammation -- Localized Inflammatory Responses -- Chronic Inflammation -- Fever -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 3 Adaptive Immunity -- Cells and Organs Involved in Adaptive Immunity -- The Lymphatic Organs -- Lymphocyte Migration and Recirculation -- The Fate of Antigen after Penetration -- Frequency of Antigen-Specific Naïve Lymphocytes -- Interrelationship between Innate and Adaptive Immunity -- Review Questions -- Answers to Review Questions -- Chapter 4 Immunogens and Antigens -- Introduction -- Requirements for Immunogenicity -- Foreignness -- High Molecular Weight -- Chemical Complexity -- Degradability. ; Haptens -- Further Requirements for Immunogenicity -- Primary and Secondary Responses -- Antigenicity and Antigen-Binding Site -- Epitopes Recognized by B Cells and T Cells -- Major Classes of Antigens -- Binding of Antigen with Antigen-Specific Antibodies or T Cells -- Cross-Reactivity -- Adjuvants -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 5 Antibody Structure and Function -- Introduction -- Isolation and Characterization of Immunoglobulins -- Structure of Light and Heavy Chains -- Domains -- Hinge Region -- Variable Region -- Immunoglobulin Variants -- Isotypes -- Allotypes -- Idiotypes -- Structural Features of IgG -- Biologic Properties of IgG -- Agglutination and Formation of Precipitate -- Passage through the Placenta and Absorption in Neonates -- Opsonization -- Antibody-Dependent Cell-Mediated Cytotoxicity -- Activation of Complement -- Neutralization of Toxins -- Immobilization of Bacteria -- Neutralization of Viruses -- Structural Features of IgM -- Biologic Properties of IgM -- Complement Fixation -- Neonatal Immunity and First Line of Humoral Defense -- Agglutination -- Isohemagglutinins -- Structural and Biologic Properties of IgA -- Biologic Properties of IgA -- Role in Mucosal Infections -- Bactericidal Activity -- Antiviral Activity -- Structural and Biologic Properties of IgD -- Structural and Biologic Properties of IgE -- Importance of IgE in Parasitic Infections and Hypersensitivity Reactions -- Kinetics of the Antibody Response Following Immunization -- Primary Response -- Secondary Response -- The Immunoglobulin Superfamily -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 6 Antigen-Antibody Interactions, Immune Assays, and Experimental Systems -- Introduction -- Antigen-Antibody Interactions. ; Primary Interactions Between Antibody and Antigen -- Association Constant -- Affinity and Avidity -- Secondary Interactions between Antibody and Antigen -- Agglutination Reactions -- Precipitation Reactions -- Immunoassays -- Direct-Binding Immunoassays -- Solid-Phase Immunoassays -- Immunofluorescence -- Direct Immunofluorescence -- Indirect Immunofluorescence -- Flow Cytometry -- Immunoabsorption and Immunoadsorption -- Cellular Assays -- Assays of Lymphocyte Function -- B-Cell and T-Cell Proliferation Assays -- Antibody Production by B Cells -- Effector Cell Assays for T Cells and Natural Killer Cells -- Cell Culture -- Primary Cell Cultures and Cloned Lymphoid Cell Lines -- B-Cell Hybridomas and Monoclonal Antibodies -- T-Cell Hybridomas -- Genetically Engineered Molecules and Receptors -- Experimental Animal Models -- Inbred Strains -- Adoptive Transfer -- SCID Mice -- Thymectomized and Congenitally Athymic (Nude) Mice -- Transgenic Mice and Gene Targeting -- Transgenic Mice -- Knockout and Knock-in Mice -- Analysis of Gene Expression -- Microarrays to Assess Gene Expression -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 7 The Genetic Basis of Antibody Structure -- Introduction -- A Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression -- Genetic Events in Synthesis of Ig Chains -- Organization and Rearrangement of Light-Chain Genes -- κ-Chain Synthesis -- λ-Chain Synthesis -- Organization and Rearrangement of Heavy-Chain Genes -- Allelic Exclusion and the Regulation of Ig Gene Expression -- Class or Isotype Switching -- Generation of Antibody Diversity -- Presence of Multiple V Genes in the Germline -- VJ and VDJ Combinatorial Association -- Random Assortment of H and L Chains -- Junctional Diversity -- Somatic Hypermutation -- Somatic Gene Conversion. ; Role of Activation-Induced Cytidine Deaminase in Generating Antibody Diversity -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 8 Biology of the B Lymphocyte -- Introduction -- Development of B Lymphocytes -- Overview -- Sites of Early B-Cell Differentiation -- Pro-B and Pre-B Cells: First Ig Rearrangements -- Immature B Cells -- Transitional B cells -- Mature B Cells -- Plasma Cells -- Memory B Cells -- Sites of Antibody Synthesis -- Interaction of Antigen, B Cells, and Helper T Cells in the Lymph Node -- Events in the Germinal Center -- Antibody Synthesis in Mucosal Tissue -- Thymus-Independent Antibody Responses -- B-Cell Membrane Proteins -- Stage-Specific Markers -- Antigen-Binding Molecules: Membrane Immunoglobulin -- Signal Transduction Molecules Associated with Membrane Immunoglobulin -- Molecules Involved in T-B Cell Interactions -- Homing -- Intracellular Signaling in B Cells -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 9 How T Cells Recognize Antigen: The Role of the Major Histocompatibility Complex -- Introduction -- How The MHC Got Its Name -- MHC Role in Antigen Presentation -- Different MHC Molecules Are Expressed by Distinct Host Cells and Interact with Different Sets of T Cells -- MHC Class I -- MHC Class II -- Variability of MHC Class I and MHC Class II Molecules -- Structure of MHC Class I and Class II Molecules -- MHC Class I -- Structure of MHC Class II Molecules -- Antigen Processing and Presentation: How MHC Molecules Bind Peptides and Create Ligands That Interact with T Cells -- Exogenous Antigens and Generation of MHC Class II-Peptide Complexes -- Endogenous Antigens: Generation of MHC Class I-Peptide Complexes -- Cross-Presentation: Exogenous Antigens Presented in the MHC Class I Pathway. ; Which Antigens Trigger Which T-Cell Responses? -- MHC Molecules Bind Peptides Derived from Self-Molecules -- Inability to Respond to an Antigen -- Other Types of Antigen That Activate T-Cell Responses -- Superantigens -- Lipids and Glycolipids -- Multiple Antigens Activate γδ T Cells -- Genes of the HLA Region -- Nomenclature of Polymorphic MHC Molecules -- Regulation of Expression of MHC Genes -- Codominant Expression -- Coordinate Regulation -- Inheritance of MHC Genes -- MHC in Other Species -- Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 10 Biology of the T Lymphocyte -- Introduction -- The Antigen-Specific T-Cell Receptor -- Molecules That Interact with Antigen -- The T-Cell Receptor Complex -- Co-Receptors -- Other Important Molecules Expressed on the T-Cell Surface -- γδ T Cells -- Genes Coding for T-Cell Receptors -- Generation of T-Cell Receptor Diversity -- T-Cell Differentiation in the Thymus -- The Thymus as Primary Organ for T-Cell Differentiation -- Key Steps in Thymic Differentiation -- Early T-Cell Receptor Gene Rearrangements: Double-Negative Cells and Splitting Off of γδ T Cells -- Pre-T Cells -- Double-Positive Cells -- Thymic Selection -- Leaving the Thymus -- Generation of the T-Cell Repertoire -- Characteristics of αβ T Cells Emerging from the Thymus -- Further Differentiation of CD4+ and CD8+ T Cells Outside the Thymus -- Differentiation of Other Cell Types in the Thymus -- References and Bibliography -- Review Questions -- Answers to Review Questions -- Chapter 11 Activation and Function of T Cells -- Introduction -- A Two-Signal Model for the Activation of T Cells -- Dendritic Cells Are the Key APC for Naïve T Cells -- Activation of CD4+ T Cells. ; Paired Interactions at the Surface of the APC and CD4+ T Cell.
• Sommario/riassunto: Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: Has been fully revised and updated, with a brand new art program to help reinforce learning Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area Highlights important therapeutic successes resulting from targeted antibody therapies Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications.
• Titolo autorizzato: Immunology
• ISBN: 9781118396902; 1118396901; 9781118396919
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910964455203321
• Lo trovi qui: Univ. Federico II