Green chemistry in the pharmaceutical industry / / Edited by Peter J. Dunn, Andrew S. Wells, and Michael T. Williams

• Pubblicazione: Weinheim, : Wiley-VCH, 2010
• Descrizione fisica: 1 online resource (390 p.)
• Disciplina: 615.19
• Soggetto topico: Green chemistry; Environmental management
• Altri autori: DunnPeter WellsAndrew WilliamsMichael T
• Note generali: Description based upon print version of record.
• Nota di contenuto: Green Chemistry in the Pharmaceutical Industry; Foreword; Contents; List of Contributors; 1: Introduction to Green Chemistry, Organic Synthesis and Pharmaceuticals; 1.1 The Development of Organic Synthesis; 1.2 The Environmental Factor; 1.3 The Role of Catalysis; 1.4 Green Chemistry: Benign by Design; 1.5 Ibuprofen Manufacture; 1.6 The Question of Solvents: Alternative Reaction Media; 1.7 Biocatalysis: Green Chemistry Meets White Biotechnology; 1.8 Conclusions and Prospects; References; 2: Green Chemistry Metrics; 2.1 Introduction; 2.2 Measuring Resource Usage; 2.2.1 Focus on Solvents ; 2.2.2 Focus on Renewables2.2.3 Cleaning and Maintenance; 2.3 Life Cycle Assessment (LCA); 2.4 Measuring Chemistry and Process Efficiency; 2.5 Measuring Process Parameters and Emissions; 2.6 Real Time Analysis; 2.6.1 Scalability; 2.6.2 Controllability; 2.6.3 Robustness; 2.7 Operational Efficiency; 2.8 Measuring Energy; 2.9 Measuring the Toxicity of All the Substrates; 2.9.1 Occupational Exposure Hazard and Risk; 2.10 Measuring Degradation Potential; 2.11 Measuring the Inherent Safety or Lack of Inherent Safety; 2.12 Conclusions; References; 3: Solvent Use and Waste Issues ; 3.1 Introduction to Solvent Use and Waste Issues3.1.1 Introduction; 3.1.2 Process Efficiency Metrics; 3.1.3 Impact Beyond the Plant - Solvent Life Cycle; 3.1.4 Solvent Utilization; 3.1.5 Solvents Used in the Pharmaceutical Industry; 3.1.6 Solvent Use in Process Development; 3.1.7 Consequences of Excessive Solvent Use; 3.1.8 Waste Management Practices in the United States; 3.2 Solvent and Process Greenness Scoring and Selection Tools; 3.2.1 Review of Solvent and Process Scoring Methods; 3.2.1.1 Greenness Assessment of Pharmaceutical Processes and Technology ; 3.2.1.2 Greenness Scoring Methods for Solvents3.2.1.3 The GSK Solvent Selection Guide; 3.2.1.4 The Rowan Solvent Greenness Index Method; 3.3 Waste Minimization and Solvent Recovery; 3.3.1 Minimizing Solvent Use; 3.3.1.1 Batch versus Continuous Reactors; 3.3.1.2 Biosynthetic Processes; 3.3.1.3 Solid-State Chemistry; 3.3.1.4 Telescoping; 3.3.2 Recycling Solvents; 3.3.2.1 Methods to Recover and Reuse Solvents; 3.3.2.2 Issues with Solvent Recovery and Reuse; Acknowledgments; References; 4: Environmental and Regulatory Aspects; 4.1 Historical Perspective; 4.2 Pharmaceuticals in the Environment ; 4.2.1 Presence4.2.2 Persistence; 4.2.3 Bioaccumulation; 4.2.4 Ecotoxicology; 4.2.5 The Current State of the Science; 4.3 Environmental Regulations; 4.3.1 Product Regulations; 4.3.2 Process Regulations; 4.3.2.1 Chemicals Control; 4.3.2.2 Integrated Pollution Control; 4.3.3 Environmental Quality Regulations; 4.4 A Look to the Future; References; 5: Synthesis of Sitagliptin, the Active Ingredient in Januvia® and Janumet®; 5.1 Introduction; 5.2 First-Generation Route; 5.3 Sitagliptin through Diastereoselective Hydrogenation of an Enamine. The PGA Enamine-Ester Route; 5.4 The Triazole Fragment ; 5.5 Direct Preparation of β-Keto Amides
• Sommario/riassunto: Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friend
• Titolo autorizzato: Green chemistry in the pharmaceutical industry
• ISBN: 1-282-48272-6; 9786612482724; 3-527-62968-8; 3-527-62969-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910877326303321
• Lo trovi qui: Univ. Federico II