Chitosan for biomaterials . IV Biomedical applications / / R. Jayakumar, M. Prabaharan, editors

• Pubblicazione: Cham, Switzerland : , : Springer, , [2021]; ©2021
• Descrizione fisica: 1 online resource (472 pages)
• Disciplina: 610.28
• Soggetto topico: Biomedical engineering
• Persona (resp. second.): JayakumarR (Rangasamy); PrabaharanM
• Nota di contenuto: Intro -- Preface -- Contents -- Different Forms of Chitosan and Its Derivatives as Hemostatic Agent and Tissue Sealants -- 1 Introduction -- 2 Different Forms of Chitosan and Its Derivatives as Hemostatic Agent -- 2.1 Gauze/Dressing Based Hemostatic Agent -- 2.2 Scaffold/Sponge/Foam/Film Based Hemostatic Agent -- 2.3 Granules/Particles/Powder Based Hemostatic Agent -- 2.4 Hydrogel-Based Hemostatic Agent -- 3 Chitosan and Its Derivatives as Tissue Sealants -- 4 Summary -- References -- Chitosan Nanofibers in Regenerative Medicine -- 1 Introduction -- 2 Chitosan Nanofibrous Membranes in Regenerative Medicine -- 2.1 Tissue Engineering -- 2.1.1 Guided Bone Regeneration and Bone Tissue Engineering -- 2.1.2 Soft Tissue Regeneration -- 2.2 Drug Delivery -- 2.2.1 Antibacterial -- 2.2.2 Dental and Bone Regeneration -- 2.2.3 Others -- 2.3 Wound Healing -- 2.3.1 Antibacterial Wound Healing -- 2.3.2 Anti-Leishmania Wound Dressing -- 2.3.3 Burn and Diabetic Wound Healing -- 3 Future Direction and Conclusion -- References -- 3D-Printed Chitosan Composites for Biomedical Applications -- 1 Introduction -- 2 Tissue Engineering -- 3 Chitosan -- 4 Chitosan Bio-Ink Production -- 5 3D-Printed Chitosan Composites -- 6 Different Methods Used in 3D Printing -- 6.1 Additive Manufacturing -- 6.2 Extruder -- 6.3 Fused Deposition Model (FDM) -- 6.4 Selective Laser Sintering (SLS) -- 6.5 Inkjet Printing -- 6.6 Thermoplastic Printing -- 6.7 Pneumatic Printing -- 7 Biomedical Applications -- 7.1 Tissue Engineering -- 7.2 Drug Delivery -- 7.3 Biosensor -- 7.4 Stem Cell Interaction with 3D-Printed Chitosan Composites -- 8 Future Approaches -- 9 Conclusion -- References -- Chitosan and Its Potential Use for the Delivery of Bioactive Molecules in Bone Tissue Engineering -- 1 Introduction -- 2 Bioactive Molecules in Bone Tissue Engineering -- 2.1 Growth Factors. ; 2.2 Endocrine Hormones -- 2.3 Other Bioactive Drugs -- 3 Chitosan -- 3.1 Sources -- 3.2 Extraction -- 3.3 Structure and Physicochemical Properties -- 3.4 Medicinal and Pharmaceutical Properties -- 4 Drug Delivery Systems -- 4.1 Colloidal Carriers -- 4.2 Nanomaterials for Drug Modulated Tissue Repair -- 4.3 Bio-inspired Nanocarriers -- 4.4 Miscellaneous Nanocarriers -- 5 Chitosan Formulation in Drug Delivery Applications -- 5.1 Chitosan Nanoparticles -- 5.2 Chitosan Nanofibers -- 5.3 Chitosan Hydrogels -- 5.4 Chitosan Microneedles -- 5.5 Chitosan Microspheres -- 6 Potential of Chitosan Delivery System in Bone Tissue Engineering -- 6.1 Growth Factor Delivery -- 6.2 Nucleic Acid Delivery -- 6.3 Phytocompound Delivery -- 7 Summary -- References -- Chitosan Based Biomaterials for Periodontal Therapy -- 1 Introduction -- 2 Periodontal Problems -- 2.1 Current Treatment Modalities and Their Shortcomings -- 2.2 Use of Biomaterials in Periodontal Therapy -- 3 Chitosan as a Biomaterial -- 3.1 Advantages of Chitosan in Periodontal Therapy -- 4 Application of Chitosan in Periodontal Therapy -- 4.1 Scaffold -- 4.1.1 Without Bio-active Molecules -- 4.1.2 With Bio-active Molecules -- 4.2 Hydrogels -- 4.2.1 Non-injectable Hydrogels -- 4.2.2 Injectable Hydrogels -- 4.3 Fibers -- 5 Summary and Future Directions -- References -- Generations of Chitosan: The Progress in Drug Delivery -- 1 Introduction -- 2 Synthesis of Thiolated Chitosan -- 2.1 First Generation: Thiolated Chitosan -- 2.2 Second Generation: Preactivated/S-Protected Chitosan -- 2.2.1 Method 1: Chitosan-TGA Conjugates -- 2.2.2 Method 2: Chitosan-EDTA-cys Conjugates -- 2.3 Third Generation: Less Reactive S-Protected Chitosan -- 3 Properties -- 3.1 Toxicity and Cell Viability -- 3.2 Mucoadhesive Properties -- 3.3 Rheological Studies -- 3.4 Permeation Enhancement Effect -- 3.5 Efflux Pump Inhibition. ; 3.6 Controlled Drug Release Properties -- 4 In Vivo Studies: Proof of Concept -- 4.1 Buccal Drug Delivery -- 4.2 Nasal Drug Delivery -- 4.3 Ocular Drug Delivery -- 4.4 Oral Drug Delivery -- 4.5 Vaginal Drug Delivery -- 5 Conclusions -- References -- Recent Progress in Biomedical Applications of Chitosan Derivatives as Gene Carrier -- 1 Introduction -- 2 Factors Affecting the Transfection Efficiency of Chitosan -- 3 Chitosan Derivatives as Gene Carriers -- 3.1 Chitosan Derivatives for DNA Delivery -- 3.1.1 Chitosan Derivatives for DNA Delivery in Cancer -- 3.1.2 Chitosan Derivatives for DNA Delivery in Tissue Engineering -- 3.1.3 Chitosan Derivatives for DNA Vaccine Delivery -- 3.2 Chitosan Derivatives for RNA Delivery -- 3.2.1 Chitosan Derivatives in siRNA Delivery System -- 3.2.2 Chitosan Derivatives in shRNA Delivery System -- 3.2.3 Chitosan Derivatives in MiRNA Delivery System -- 3.3 Chitosan Derivatives for Gene Editing -- 4 Challenges and Future Directions -- References -- Chitosan Polymeric Micelles as Oral Delivery Platform of Hydrophobic Anticancer Drugs -- 1 Introduction -- 2 Oral Delivery of Drugs -- 2.1 Limitations to the Oral Administration of Drugs -- 2.2 Intestinal Absorption Mechanisms -- 3 Chitosan Modifications into an Amphiphilic Polymer -- 3.1 Alkylation -- 3.2 Acylation -- 3.3 Hydroxylation and Carboxylation -- 4 Polymeric Micelles as Delivery Platform -- 5 Hydrophobic Anticancer Drugs Loaded into Polymeric Micelles -- 5.1 Paclitaxel Delivery -- 5.2 Curcumin Delivery -- 5.3 Other Hydrophobic Anticancer Drugs -- 6 Conclusions -- References -- Chitosan-Based Theranostics for Cancer Therapy -- 1 Introduction -- 2 Theranostics Based on Chitosan and Its Derivatives -- 2.1 Chitosan Loaded with Photosensitizers/Photothermal Agents -- 2.2 Chitosan Loaded with QDs -- 2.3 Chitosan-Noble Metal Conjugates -- 2.4 Chitosan-Based Magnetic NPs. ; 2.5 Chitosan-Based Hybrid NPs -- 2.6 Chitosan-Based Multimodal Nanocomposites -- 3 Summary -- References -- An Overview on Chitosan-Based Adjuvant/Vaccine Delivery Systems -- 1 Introduction -- 2 Chitosan and Immunization -- 3 Chitosan-Based Systems for Immunization -- 4 Chitosan for Mucosal Immunization -- 4.1 Oral and Sublingual Delivery -- 4.2 Nasal Delivery -- 5 Chitosan for Parenteral Immunization -- 6 Chitosan for Cutaneous Immunization -- 7 Conclusion -- References -- Enhanced Topical Delivery of Drugs to the Eye Using Chitosan Based Systems -- 1 Eye -- 2 Ocular Barriers -- 2.1 Anatomical Barriers -- 2.2 Physiological Barriers -- 3 Properties of Chitosan as a Topical Ocular Delivery System -- 3.1 Mucoadhesive Potential -- 3.2 Penetration Enhancement Property -- 3.3 In Situ Gelling Property -- 3.4 Antimicrobial Potential -- 3.5 Transfection Enhancement Property -- 3.6 Controlled Drug Delivery Potential -- 4 Chitosan and Its Derivatives Based Topical Ocular Drug Delivery Systems -- 4.1 Hydrogel Based Systems -- 4.1.1 Chitosan -- 4.1.2 From Modified Chitosan -- 4.1.3 From Chitosan Blends -- 4.2 Colloidal Nanocarriers -- 4.2.1 Nanoparticles -- Ionotropic Gelation -- By Spray Drying -- From Modified Chitosan -- 4.2.2 Liposomes -- 4.2.3 Micelles -- 4.2.4 Other Combined Delivery Systems -- 4.3 Ocular Lenses and Ocuserts -- 5 Chitosan Based Ocular Films -- 6 Chitosan Based Ocular Inserts -- 7 Chitosan Based Ocular Gels -- 8 Conclusion -- References -- Application of Chitosan and Its Derivatives in Transdermal Drug Delivery -- 1 Introduction -- 1.1 Chitosan Derivatives -- 2 Chitosan Based Drug Delivery Approaches -- 3 Chitosan and Chitosan Derivatives in Transdermal Drug Delivery -- 3.1 Chitosan Based Transdermal Patches -- 3.2 Chitosan Based Composite Films -- 3.3 Chitosan Based Vesicular Drug Delivery Systems -- 3.4 Chitosan Based Microspheres. ; 3.5 Chitosan Based Microneedles -- 3.6 Chitosan Based Dendrimers -- 3.7 Chitosan Based Nanocarriers -- 3.7.1 Chitosan Based Nanogel -- 3.7.2 Chitosan Based Nanoemulsion -- 3.7.3 Chitosan Based Nanolipid Carrier (NLC) -- 3.7.4 Chitosan Based Nanoparticles -- 4 Summary -- References -- Delivery of Biomolecules Using Chitosan Wound Dressings -- 1 Bioactive Wound Dressings -- 2 Chitosan Wound Dressings (CWD) as Hemostatic Delivery Platforms -- 3 CWD as Antimicrobial Activity Delivery Systems -- 4 CWD Delivery of Inflammation Modulating Agents -- 5 CWD Mediating the Wound Healing and Wound Repair Process -- 6 Conclusion -- References.
• Titolo autorizzato: Chitosan for biomaterials
• ISBN: 3-030-83021-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910495224303321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in polymer science ; ; 288.