Chemical sensors and biosensors for medical and biological applications / / Ursula E. Spichiger-Keller

• Autore: Spichiger-Keller Ursula E.
• Pubblicazione: [Berlin, Germany] : , : Wiley-VCH, , [2008]; ©[2008]
• Descrizione fisica: 1 online resource (428 p.)
• Disciplina: 660.6; 681.2
• Soggetto topico: Chemical detectors; Biosensors
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Chemical Sensors and Biosensors for Medical and Biological Applications; Preface; Contents; 1 Introduction; 1.1 Chemical Sensors as Alternative Analytical Tools; 1.2 The Concept of Chemical and Biochemical Sensors; 1.3 Recognition Processes and Sensor Technology: Milestones; 1.4 Goals for Future Developments and Trends; 1.4.1 Trends; 1.4.2 Miniatuization Nanotechnology; 1.4.3 In Vivo and In Situ Monitoring; 1.4.4 The Analytical Laboratory in the 21st Century (Conclusions); References; 2 Chemical and Biochemical Sensors; 2.1 Classification, Specification, and Nomenclature of Chemical Sensors ; 2 2 Molecular Recognition Processes for Ions and Neutral Species2.2.1 Introduction; 2.2.2 Molecular Interactions: Tools and Calculations; 2.2.3 Molecular Recognition of Ions; 2.2.4 Hydrogen Bonds; 2.2.5 Molecular Recognition of Enantiomers; 2.2.6 Molecular Interactions within the Aqueous Medium; 2.2.7 Catalysis by Enzymes, Enzyme Mimics and Host-Reactands; 2.2.8 Catalytic Antibodies; 2.2.9 Multitopic Recognition of Immunological Systems; 2.2.10 Conclusions and Considerations for Ligand Design; References; 3 Controlling Sensor Reactions ; 3.1 Thermodynamically Controlled Sensor Reactions: Reversibility and Thermodynamic Equilibrium3.1.1 The Chemical Potential and the Partition Equilibrium; 3.1.2 The Recognition and Transduction Process; 3.1.3 The Electrochemical Potential and the (Potentiometric) Sensor Response; 3.2 Thermodynamics of Nonequilibria: Diffusion and Steady-State; 3.3 Rate-Controlled Sensor Reactions: Mediated Enzyme Reactions; 3.4. Nonthermodynamic Assumptions; 3.4.1 Activity Versus Concentrations; 3.4.2 Ionic Strength and Estimates of Activity Coefficients ; 3.4.3 Activity and Concentration of an Electrolyte: IFCC / IUPAC Definitions3.4.4 The Osmotic Coefficient; 3.4.5 Calibration, Standardization, and Comparisons with Definitive or Reference Procedures; 3.4.6 The Liquid Junction Potential under Physiological Conditions; References; 4 The Artificial Analyte-Selective Membrane Limitations, Technological Precautions and Developments; 4.1 Introduction; 4.2 Types of Membranes and Membrane Models; 4.2.1 The Biological Membrane; 4.2.2 Artificial Membranes; 4.3 The Selectivity Coefficient; 4.4 The Membrane Composition and the Membrane Medium ; 4.4.1 The Influence of the Permittivity and of Plasticizers4.4.2 The Effect of Electron Pair Donor (EPD) and Acceptor (EPA) . Properties of Solvents . Solubilization Properties of the Membrane; 4.4.3 The Influence of the Aqueous Sample Environment; 4.4.4 The Influence of the Surface Tension; 4.4.5 The Effect of Lipophilic Anionic Sites; 4.4.6 The Effect of the Ligand Concentration; 4.5 Response Behavior, Sensitivity, and Detection Limit; 4.6 Lifetime,Lipophilicity, and Immobilization; 4.7 Interactions by the Biological Matrix and Precautions; 4.7.1 Biocompatibility ; 4.7.2 Possible Mechanism of Protein Adsorption
• Sommario/riassunto: This book introduces the principles and concepts of chemical and biochemical sensors for analyzing medical as well as biological samples. For applications like analyzing or monitoring gastric juice or blood plasma, the potential of sensors is exceptionally large. Focussed on these applications, the interpretation of analytical results is explained. Specific advantages are compared to other analytical techniques. Numerous tables with data provide useful information not easily found elsewhere and make a handy source of reference.Ursula E. Spichiger-Keller is head of the Center for Chemical S
• Titolo autorizzato: Chemical sensors and biosensors for medical and biological applications
• ISBN: 1-282-01030-1; 9786612010309; 3-527-61228-9; 3-527-61226-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830428303321
• Lo trovi qui: Univ. Federico II