Bone Marrow Pathology

• Autore: Bain Barbara J
• Pubblicazione: Newark : , : John Wiley & Sons, Incorporated, , 2025; ©2024
• Edizione: 6th ed.
• Descrizione fisica: 1 online resource (771 pages)
• Disciplina: 616.4/107
• Altri autori: ClarkDavid M WilkinsBridget S SovaniVishakha
• Nota di contenuto: Cover -- Dedication page -- Title page -- Copyright page -- Contents -- Preface to the sixth edition -- Acknowledgements -- Abbreviations -- Chapter One The normal bone marrow: examining and reporting bone marrow specimens -- The distribution of haemopoietic marrow -- The organization of the bone marrow -- Bone -- Other connective tissue elements -- Haemopoietic and other cells -- Examination of the bone marrow -- Bone marrow aspiration -- Trephine biopsy of bone marrow -- Relative advantages of aspiration and core biopsy -- Other techniques -- Cellularity -- Haemopoietic and mesenchymal cells -- Erythropoiesis -- Granulopoiesis -- Monocytopoiesis -- Stromal dendritic cells -- Megakaryopoiesis and thrombopoiesis -- Mast cells -- Ostoblasts and osteoclasts -- Fat cells -- Lymphopoiesis -- Lymphocytes -- Plasma cells -- Storage and erythroblast iron -- The cellular composition of bone marrow -- Interpretation of bone marrow aspirates and trephine biopsies -- Examination of bone marrow aspirate films -- Reporting a bone marrow aspirate -- Examination of trephine biopsy sections -- Reporting trephine biopsy sections -- Guidelines, integrated reporting and audit -- Digital pathology -- Artificial intelligence and automated image analysis -- Artefacts -- References -- Chapter Two Special techniques applicable to bone marrow diagnosis -- Cytochemical and histochemical stains -- Cytochemical stains on bone marrow aspirates -- Histochemical stains on trephine biopsy sections -- Immunophenotyping -- Immunophenotyping by immunofluorescence flow cytometry -- Immunocytochemistry -- Relative advantages of flow cytometry and immunocytochemistry -- Antibodies for flow cytometry and immunocytochemistry -- Immunohistochemistry -- Cytogenetic analysis -- Molecular genetic analysis -- Fluorescence and other in situ hybridization techniques -- Southern blot analysis. ; The polymerase chain reaction -- Reverse transcriptase polymerase chain reaction -- Modifications of PCR and RT-PCR techniques -- Microarray analysis -- Next generation sequencing -- Other molecular genetic techniques -- The application of molecular genetic techniques in the investigation of haematological neoplasms -- Ultrastructural examination -- Bone marrow culture for assessment of haemopoietic progenitor cell numbers -- Short-term culture -- Long-term culture -- Bone marrow culture for microorganisms -- References -- Chapter Three Infection and reactive changes -- Infection -- Bacterial infection -- Viral infection -- Fungal infections -- Parasitic diseases -- Bone marrow granulomas -- Reactive lymphoid infiltrates -- Plasmacytosis and cytological abnormalities in plasma cells -- Mast cells -- Histiocytosis -- Haemophagocytic syndromes -- Iron overload -- HIV infection and the acquired immune deficiency syndrome -- Blood vessels and vascular lesions -- Bone marrow necrosis -- Gelatinous transformation -- Amyloid deposition -- Bone marrow fibrosis -- References -- Chapter Four Acute myeloid leukaemia, mixed phenotype acute leukaemia, the myelodysplastic neoplasms/syndromes and histiocytic and dendritic cell neoplasms -- Acute myeloid leukaemia -- The FAB classification of acute myeloid leukaemia -- M0 AML -- M1 and M2 AML -- M3 and M3 variant AML -- M4 AML -- M5 AML -- M6 AML -- M7 AML -- The WHO classification of acute myeloid leukaemia -- Problems and pitfalls in the diagnosis of AML -- Acute leukaemia of mixed or ambiguous lineage -- The myelodysplastic neoplasms/syndromes -- The WHO and International Consensus classifications of the myelodysplastic syndromes -- Genetically defined myelodysplastic neoplasms -- Morphologically defined myelodysplastic neoplasms -- Myelodysplastic neoplasms/syndromes of childhood. ; Problems and pitfalls in the diagnosis of myelodysplastic syndromes -- Clonal cytopenia of undetermined significance and idiopathic cytopenia of unknown significance -- Histiocytic and dendritic cell neoplasms -- References -- Chapter Five Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions -- Myeloproliferative neoplasms -- Essential thrombocythaemia -- Myelodysplastic/myeloproliferative neoplasms -- References -- Chapter Six Lymphoproliferative disorders -- Bone marrow infiltration in lymphoproliferative disorders -- B-lineage lymphomas and leukaemias -- B-lymphoblastic leukaemia/lymphoma -- Chronic lymphocytic leukaemia/small lymphocytic lymphoma -- Monoclonal B-cell lymphocytosis -- B-cell prolymphocytic leukaemia -- Hairy cell leukaemia -- Lymphoplasmacytic lymphoma -- IgM monoclonal gammopathy of undetermined significance -- Heavy chain diseases -- Follicular lymphoma -- Primary cutaneous follicle centre cell lymphoma -- Mantle cell lymphoma -- Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and other marginal zone lymphomas -- Splenic marginal zone lymphoma -- Nodal marginal zone B-cell lymphoma -- Splenic diffuse red pulp small B-cell lymphoma -- Splenic B-cell lymphoma/leukaemia with prominent nucleoli/hairy cell leukaemia variant -- Diffuse large B-cell lymphoma and other large B-cell lymphomas -- Kaposi sarcoma herpesvirus/human herpesvirus 8-positive lymphomas -- Lymphoid proliferations and lymphomas associated with immune deficiency/dysregulation -- Burkitt lymphoma -- Lymphoproliferative disorders of T lineage and natural killer (NK) lineage -- T-lymphoblastic leukaemia/lymphoma, nos -- Early T-precursor acute lymphoblastic leukaemia/lymphoma -- NK-lymphoblastic leukaemia/lymphoma -- T-cell prolymphocytic leukaemia. ; T-cell large granular lymphocytic leukaemia -- NK large granular lymphocytic leukaemia/chronic lymphoproliferative disorder of NK lineage -- Aggressive NK-cell leukaemia -- Ebv-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood/EBV-positive T-cell and NK-cell lymphoproliferative disorders of childhood -- Extranodal NK/T-cell lymphoma/extranodal NK/T-cell lymphoma, nasal type -- Sézary syndrome -- Mycosis fungoides -- Subcutaneous panniculitis-like T-cell lymphoma -- Primary cutaneous gamma-delta T-cell lymphoma -- Nodal T-follicular helper cell lymphoma, angioimmunoblastic type (angioimmunoblastic Tcell lymphoma) -- Adult T-cell leukaemia/lymphoma -- Hepatosplenic T-cell lymphoma -- Anaplastic large cell lymphoma, ALK-positive -- Anaplastic large cell lymphoma, ALK-negative -- Enteropathy-associated T-cell lymphoma -- Monomorphic epitheliotropic intestinal T-cell lymphoma -- Breast-implant-associated anaplastic large cell lymphoma -- Peripheral T-cell lymphoma, not otherwise specified -- Hodgkin lymphoma -- Post-transplant and other immunodeficiency-associated lymphoproliferative disorders and their relationship to the epstein-barr virus -- References -- Chapter Seven Plasma cell neoplasms and related conditions -- Plasma cell neoplasm -- Plasma cell myeloma/multiple myeloma -- Plasma cell leukaemia -- Non-IgM monoclonal gammopathy of undetermined significance -- Lymphoplasmacytic neoplasms -- IgM monoclonal gammopathy of undetermined significance (IgM MGUS) -- Waldenström macroglobulinaemia -- Other syndromes associated with secretion of a paraprotein -- Immunoglobulin-related (AL) amyloidosis -- Monoclonal immunoglobulin deposition diseases/light chain and heavy chain deposition diseases -- Essential and other paraprotein-associated cryoglobulinaemia -- Cold haemagglutinin disease -- Alpha heavy chain disease. ; Gamma heavy chain disease -- Mu heavy chain disease -- The POEMS syndrome -- The TEMPI syndrome -- The AESOP syndrome -- Acquired angio-oedema associated with plasma cell neoplasia -- References -- Chapter Eight Disorders of erythropoiesis, granulopoiesis and thrombopoiesis -- Disorders of red cells -- Iron deficiency anaemia -- Sideroblastic anaemia -- Thalassaemia trait and thalassaemia intermedia -- Thalassaemia major -- Haemoglobin H disease -- Haemolytic anaemias -- Congenital dyserythropoietic anaemia -- Megaloblastic anaemia -- Anaemia of chronic disease -- Sickle cell disease -- Pure red cell aplasia (including Blackfan-Diamond syndrome) -- Polycythaemia -- Disorders of leucocytes -- Congenital neutropenia -- Inherited and other constitutional neutrophilia -- Jordans anomaly -- Pelger-huët anomaly -- Agranulocytosis -- Other drug-induced neutropenia -- Autoimmune neutropenia -- Idiopathic hypereosinophilic syndrome -- Chédiak-Higashi syndrome -- Disorders of platelets -- Congenital thrombocytopenia -- Acquired thrombocytopenias -- Familial thrombocytosis -- Reactive thrombocytosis -- References -- Chapter Nine Miscellaneous disorders -- Non-metastatic effects of cancer -- Bone marrow dysplasia with polyclonal haemopoiesis -- The bone marrow in connective tissue and autoimmune disorders -- Congenital immune deficiency syndromes -- Autoimmune lymphoproliferative syndrome -- The haematological effects of anti-cancer and immunosuppressive chemotherapy -- The haematological effects of other drugs and chemicals -- The effect of irradiation on the bone marrow -- The haematological effects of alcohol -- Aplastic anaemia -- Other causes of bone marrow aplasia and hypoplasia -- Pearson syndrome and other mitochondrial cytopathies -- Other constitutional abnormalities associated with abnormal haemopoiesis -- Paroxysmal nocturnal haemoglobinuria. ; Bone marrow and other haemopoietic stem cell transplantation.
• Titolo autorizzato: Bone Marrow Pathology
• ISBN: 1-394-24483-5
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910898094903321
• Lo trovi qui: Univ. Federico II