Biology of IGF-1 : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
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| Titolo: |
Biology of IGF-1 : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
|
| Pubblicazione: | The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
| Descrizione fisica: | 1 online resource (294 p.) |
| Disciplina: | 612/.015756 |
| Soggetto topico: | Somatomedin - Physiological effect |
| Somatomedin - Pathophysiology | |
| Carcinogenesis | |
| Classificazione: | 44.78 |
| Altri autori: |
BockGregory
GoodeJamie
|
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and indexes. |
| Nota di contenuto: | Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. |
| Sommario/riassunto: | An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:the definition of danger zonesthe development of methods for early recognition of malignant states linked to IGF-1 and/or insulinpossible approaches to preventative interventionthe relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers. |
| Titolo autorizzato: | Biology of IGF-1 |
| ISBN: | 9786610272518 |
| 9781280272516 | |
| 1280272511 | |
| 9780470667538 | |
| 0470667532 | |
| 9780470869970 | |
| 0470869976 | |
| 9780470869994 | |
| 0470869992 | |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9911019855503321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
Novartis Foundation symposium ; ; 262.