Bioinformatics : Volume II: Structure, Function, and Applications / / edited by Jonathan M. Keith

• Pubblicazione: New York, NY : , : Springer New York : , : Imprint : Humana, , 2017
• Edizione: 2nd ed. 2017.
• Descrizione fisica: 1 online resource (XI, 426 p. 88 illus., 26 illus. in color.)
• Disciplina: 570.285
• Soggetto topico: Bioinformatics
• Persona (resp. second.): KeithJonathan M.
• Nota di contenuto: 3D Computational Modeling of Proteins Using Sparse Paramagnetic NMR Data -- Inferring Function from Homology -- Inferring Functional Relationships from Conservation of Gene Order -- Structural and Functional Annotation of Long Non-Coding RNAs -- Construction of Functional Gene Networks Using Phylogenetic Profiles -- Inferring Genome-Wide Interaction Networks -- Integrating Heterogeneous Datasets for Cancer Module Identification -- Metabolic Pathway Mining -- Analysis of Genome-Wide Association Data -- Adjusting for Familial Relatedness in the Analysis of GWAS Data -- Analysis of Quantitative Trait Loci -- High-Dimensional Profiling for Computational Diagnosis -- Molecular Similarity Concepts for Informatics Applications -- Compound Data Mining for Drug Discovery -- Studying Antibody Repertoires with Next-Generation Sequencing -- Using the QAPgrid Visualization Approach for Biomarker Identification of Cell-Specific Transcriptomic Signatures -- Computer-Aided Breast Cancer Diagnosis with Optimal Feature Sets: Reduction Rules and Optimization Techniques -- Inference Method for Developing Mathematical Models of Cell Signaling Pathways Using Proteomic Datasets -- Clustering -- Parameterized Algorithmics for Finding Exact Solutions of NP-Hard Biological Problems -- Information Visualization for Biological Data.
• Sommario/riassunto: This second edition provides updated and expanded chapters covering a broad sampling of useful and current methods in the rapidly developing and expanding field of bioinformatics. Bioinformatics, Volume II: Structure, Function, and Applications, Second Edition is comprised of three sections: Structure, Function, Pathways and Networks; Applications; and Computational Methods. The first section examines methodologies for understanding biological molecules as systems of interacting elements. The Applications section covers numerous applications of bioinformatics, focusing on analysis of genome-wide association data, computational diagnostic, and drug discovery. The final section describes four broadly applicable computational methods that are important to this field. These are: modeling and inference, clustering, parameterized algorithmics, and visualization. As a volume in the highly successful Methods in Molecular Biology series, chapters feature the kind of detailand expert implementation advice to ensure positive results. Comprehensive and practical, Bioinformatics, Volume II: Structure, Function, and Applications is an essential resource for graduate students, early career researchers, and others who are in the process of integrating new bioinformatics methods into their research. .
• Titolo autorizzato: Bioinformatics
• ISBN: 9781493966134; 1493966138
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9911154885003321
• Lo trovi qui: Univ. Federico II
• Serie: Methods in Molecular Biology, . 1940-6029 ; ; 1526