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Hallmarks of Parkinson’s Disease
| Hallmarks of Parkinson’s Disease |
| Autore | Alves Da Costa Cristine |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (124 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
Parkinson’s disease
unfolded protein response reticulum endoplasmic genetics alpha-synuclein prion-like spreading cell-to-cell transfer neurodegeneration mitochondrial dysfunction PINK1 neurons astrocytes microglia α-synuclein exocytosis lipids membranes Parkinson disease SNARE complex synapse vesicle fusion therapeutic target protein quality control mitochondrial quality control ubiquitin alpha-syn mitophagy Parkin mito-Keima mito-QC mito-SRAI |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069503321 |
Alves Da Costa Cristine
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Immunophenotyping in Autoimmune Diseases and Cancer
| Immunophenotyping in Autoimmune Diseases and Cancer |
| Autore | Szebeni Gábor J |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
CD8+CD28− T cells
cancer immunology glioblastoma immunotherapy malignant glioma cancer accidental cell death oncosis DDR parthanatos flow cytometry systemic lupus erythematosus T cells glycosylation sialylation lectin binding glycosylation enzymes galectin 1 choriocarcinoma hydatidiform mole galectin gestational trophoblastic disease placental-specific gene systems biology trophoblast differentiation B cells non-switched B cells systemic sclerosis dcSSc TLR CD180 RP105 CpG IL-6 IL-10 natural autoantibodies IgM citrate synthase DNA topoisomerase I unfolded protein response Inositol-requiring enzyme 1 (IRE1) PKR-like endoplasmic reticulum kinase (PERK) Glucose-regulated protein 78 (GRP78) Activating transcription factor 6 (ATF6) immune cells T cell macrophage tumor microenvironment single cell mass cytometry metastatic breast cancer myeloid-derived suppressor cells immunophenotyping breast cancer trastuzumab chimeric antigen receptor cell therapy neuroendocrine neoplasia neuroendocrine tumor neuroendocrine carcinoma immunohistochemistry syntaxin 1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557289203321 |
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Szebeni Gábor J
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Therapies for Inherited Retinal Diseases
| Molecular Therapies for Inherited Retinal Diseases |
| Autore | Collin Rob W.J |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
induced pluripotent stem cell (iPSC)
clustered regularly interspaced short palindromic repeats (CRISPR) homology-directed repair (HDR) Enhanced S-Cone Syndrome (ESCS) NR2E3 AAV retina gene therapy dual AAV gold nanoparticles DNA-wrapped gold nanoparticles ARPE-19 cells retinal pigment epithelium clathrin-coated vesicles endosomal trafficking retinitis pigmentosa autosomal dominant G56R putative dominant negative effect gapmer antisense oligonucleotides allele-specific knockdown Leber congenital amaurosis and allied retinal ciliopathies CEP290 Flanders founder c.4723A > T nonsense mutation Cilia elongation spontaneous nonsense correction AON-mediated exon skipping microRNA photoreceptors rods cones bipolar cells Müller glia retinal inherited disorders retinal degeneration antisense oligonucleotides Stargardt disease inherited retinal diseases splicing modulation RNA therapy ABCA4 iPSC-derived photoreceptor precursor cells cyclic GMP apoptosis necrosis drug delivery systems translational medicine Usher syndrome Leber congenital amaurosis RPE65 nonprofit patient registry translational protein trafficking protein folding protein degradation chaperones chaperonins heat shock response unfolded protein response autophagy therapy IRD DNA therapies RNA therapies compound therapies clinical trials Retinitis Pigmentosa GTPase Regulator adeno-associated viral Retinitis Pigmentosa (RP) choroideremia REP1 inherited retinal disease treatment apical polarity crumbs complex fetal retina PAR complex retinal organoids retinogenesis gene augmentation adeno-associated virus (AAV) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674051103321 |
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Collin Rob W.J
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Neuroprotection
| Natural Products and Neuroprotection |
| Autore | Angeloni Cristina |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (338 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
Vitamin D
Multiple Sclerosis symptom neurodegeneration oxidative injury Parkinson's disease terpenes, rotenone thymol Alzheimer's disease Centella asiatica hippocampus protein poshophatase 2 glycogen synthase kinase 3 B-cell lymphoma 2 neuroprotection nutraceuticals bioavailability stress response neurodegenerative disease bioactive compound natural extract β-amyloid peptide tau protein clinical trial human studies animal studies in vitro studies curcumin free radicals heme oxygenase safety profile type 2 diabetes inflammation vascular damage learning memory natural compound oxidative stress cognitive dysfunction cell death synapse loss protein aggregation neuroinflammation algae seaweeds neurodegenerative diseases auraptene dopamine neuron antioxidant mitochondria Chionanthus retusus flavonoid flower HO-1 NO Lippia citriodora VEE Vs relaxation depression cyclic AMP calcium blood-brain barrier catechin cognition epigallocatechin gallate green tea microbiota 5-(3,5-dihydroxyphenyl)-γ-valerolactone ascaroside pheromone C. elegans dauer neuronal signaling sexual behavior survival signals proteostasis chaperones autophagy ubiquitin-proteasome unfolded protein response natural compounds natural products ethics patients' autonomy beneficence nonmaleficence medical liability Parkinson's disease (PD) mitochondrial dysfunction dynamics hormesis ubiquitin‒proteasome system (UPS) mitophagy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557705603321 |
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Angeloni Cristina
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
| Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| Autore | Kwok Hang Fai |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
DAPK1
SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607403321 |
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Kwok Hang Fai
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein Quality Controlling Systems in Plant Responses to Environmental Stresses
| Protein Quality Controlling Systems in Plant Responses to Environmental Stresses |
| Autore | Yule Liu |
| Pubbl/distr/stampa | Frontiers Media SA, 2018 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
unfolded protein response
proteasome environmental stress autophagy plant heat shock proteins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346745403321 |
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Yule Liu
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| Frontiers Media SA, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Retina in Health and Disease
| The Retina in Health and Disease |
| Autore | Ptito Maurice |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (465 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
eye
retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer's disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557336603321 |
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Ptito Maurice
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and Autophagy
| Ubiquitin and Autophagy |
| Autore | Nazarko Taras Y |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (294 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
PSMD14
ubiquitin retrograde trafficking APP autophagy Cx43 GABARAP gap junction MAPLC3 leukodystrophies globoid cell leukodystrophy psychosine p62 proteasome toll-like receptor 4 TRAF6 BECN1 ATG12~5/16 complex Dictyostelium ubiquitin-like protein phagocytosis pinocytosis UPS ubiquitin-proteasome system crosstalk tissue specificity C. elegans NFAT5 autophagy initiation islet FIP200 unfolded protein response UPR Atg8 LC3 LIR motif SAR UBL neurodegenerative diseases autophagy-lysosome pathway lysosome selective autophagy ubiquitination degradation the ubiquitin-proteasome system plants mitophagy aggrephagy lysophagy xenophagy lipophagy nucleophagy ER-phagy cargo receptors sorting nexins retromer endosome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339503321 |
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Nazarko Taras Y
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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