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Animal Modeling in Cancer
| Animal Modeling in Cancer |
| Autore | Korinek Vladimir |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (273 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
soy
isoflavones mammary tumor prevention rodent models chemical carcinogens transgenic mice Zebrafish Drosophila rats mice NPM-1 FLT3 ITD ETO-1 IDH1/2 neural stem cells brain and nervous system cancers neurogenic niches radiotherapy sparing of neurogenic regions carcinoma consensus molecular subtypes intestine oncogenes signaling cascades tumor suppressors tumorigenesis MPN (myeloproliferative neoplasms) zebrafish iPSCs JAK2 MPL CALR thrombosis ubiquitin–proteasome system cancer mouse model gene inactivation colorectal cancer mouse models microbiota antitumor immunity melanoma mutation genetics animal model swine MeLiM progression spontaneous regression devitalization metaplasia Cdx animal models epigenetics xenotransplantation drug screen pre-clinical cancer model non-mouse models gene editing stem cells solid tumors hematologic malignancies |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557344403321 |
Korinek Vladimir
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Drugs
| Anticancer Drugs |
| Autore | O’Boyle Niamh M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Soggetto non controllato |
graphene oxide
indole androgens cyclooxygenase-2 cyclooxygenase-1 heteropolysaccharide drug conjugation drug delivery ellipticine chemical linker oesophageal cancer antiproliferative activity topoisomerase II ?-lactam DSD antibody topoisomerase inhibitors magnetic targeting cisplatin resistance steroidogenesis [18F]FDG PET/CT heterocyclic chemistry dehydroepiandrosterone antimitotic 3-vinylazetidin-2-ones glioblastoma and cancer therapy intestinal mucositis Combretastatin A-4 metabolism anti-cancer drugs maghemite COX-1 inhibitor anticancer CYP17A1 conjugate and hybrid drugs inflammation snticancer drugs P450c17 tumorigenesis cisplatin biomarker profiling cancer drug design tubulin cytochrome P450 5-fluorouracil prostate cancer abiraterone NCI screen radiation cancer immunotherapy microtubule targeted drugs cancer treatment resistance |
| ISBN | 3-03921-587-6 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367753903321 |
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O’Boyle Niamh M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Inhibitors
| Anticancer Inhibitors |
| Autore | Fantacuzzi Marialuigia |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (216 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
breast cancer
tamoxifen LY294002 synergism apoptosis cell cycle tea (Camellia sinensis) flowers BTFS A2780/CP70 ovarian cancer cells S phase cell cycle arrest nicotinamide phosphoribosyltransferase NAD+ biosynthesis inhibitor azacyclohexane anticancer drug drug design enthalpy effect NSCLC Cathepsin K cell proliferation cell migration cell invasion mTOR isatin-hydrazones cytotoxicity CDK2 inhibitor ATP competitive inhibitor ADME analysis receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity agonistic activity saponins phytochemicals tea (Camellia sinensis) flower ovarian cancer autophagy ZMYND8 tumorigenesis epigenetic regulation pro-oncogenic effects tumor suppression tacrine-coumarin derivatives DNA topoisomerases I, II lung carcinoma cells A549 chemotherapy prodrug drug targeting overexpressed enzymes ADC ADEPT GDEPT LEAPT PROTAC cyclin-dependent kinase cancer resistance small molecule inhibitors PROTACs statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin fluvastatin atorvastatin pravastatin HMG-CoA reductase inhibitors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069203321 |
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Fantacuzzi Marialuigia
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Apoptotic Cell Clearance in Health and Disease
| Apoptotic Cell Clearance in Health and Disease |
| Autore | Amiram Ariel |
| Pubbl/distr/stampa | Frontiers Media SA, 2018 |
| Descrizione fisica | 1 electronic resource (294 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
Phagocytes
immune-regulation development Efferocytosis Homeostasis neurodegeneration tumorigenesis Apoptosis receptor-ligand interactions |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346757403321 |
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Amiram Ariel
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| Frontiers Media SA, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biomarkers for Diagnosis, Complications and Therapy Effects in Civilization Diseases Management
| Biomarkers for Diagnosis, Complications and Therapy Effects in Civilization Diseases Management |
| Autore | Komosinska-Vassev Katarzyna |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (208 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
pharmacogenomics
NGS variants personalized medicine FSHR personalized drug therapy hedgehog-interacting protein impaired fasting glucose impaired glucose tolerance newly diagnosed diabetes normal glucose tolerance inflammatory bowel disease ulcerative colitis Crohn’s disease extracellular matrix components hyaluronan inflammatory bowel diseases (IBD) Crohn’s disease (CD) ulcerative colitis (UC) sulfated glycosaminoglycans (sGAG) hyaluronan (HA) soluble part of syndecan-1 (sCD138) microRNA cardiovascular disease diabetes mortality antiplatelet therapy platelet reactivity Let-7e miR-126 miR-223 miR-125a-3p CCL11 CCL24 CCL26 CCR3 CRC adiponectin adipokines rheumatology obesity overweight case control study rheumatoid arthritis TNF-α inhibitors bone turnover markers PINP PICP NTX-I CTX-I RANKL/OPG ovarian cancer interleukin 21 interleukin 22 lymphocytes macrophages dendritic cells innate lymphoid cells breast cancer extracellular matrix proteins tumorigenesis tumor microenvironment |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566458203321 |
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Komosinska-Vassev Katarzyna
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Diagnostic, Prognostic and Predictive Biological Markers in Bladder Cancer - Illumination of a Vision 2.0
| Diagnostic, Prognostic and Predictive Biological Markers in Bladder Cancer - Illumination of a Vision 2.0 |
| Autore | Ecke Thorsten |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (240 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
Metallothionein
urothelium urothelial cancer cadmium exposure zinc transporter bladder TAGLN F-actin PTEN p53 tumorigenesis proliferation invasion TERT promoter mutations FGFR3 non muscle invasive bladder cancer BCG therapy bladder cancer JAK-STAT pathway combination therapy oncolytic adenovirus virotherapy STAT3/5 inhibitor JAK inhibitor XVir-N-31 bladder cancer detection urinary biomarkers DNA methylation ECRG4 ITIH5 biomarker cancer grade metabolomics MS NMR biomarkers tumor markers prognosis heparanase syndecan-1 heparan sulfate proteoglycans (HSPGs) urothelial carcinoma miRNA quantitative PCR tumor marker voided urine cytology KDM7A histone demethylase TC-E 5002 androgen receptor drug resistance non-invasive detection telomerase somatic mutations TERT promoter region muscle-invasive bladder cancer chemotherapy immunotherapy personalized medicine predictive biomarker survivin BIRC5 macrophage KRT20 ERBB2 MIBC prediction RT-qPCR adjuvant chemotherapy survival |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557142003321 |
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Ecke Thorsten
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Disease and the Hippo Pathway: Cellular and Molecular Mechanisms
| Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| Autore | Hansen Carsten Gram |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto non controllato |
STRIPAK
skin cancer Lats2 transcription myofibroblast epigenetic Hippo cancer immunity TAZ Taz TAZ (transcriptional co-activator with PDZ-binding motif) adaptive immunity fibroblasts innate immunity LATS MST (mammalian STE20-like protein kinase) phosphorylation stem cells wound healing signal transduction angiogenesis LATS1/2 EMT protein-protein interactions structure biology Hippo pathway hippo pathway autoimmunity Mps one binder YAP/TAZ GPCR fibrosis MST1/2 YAP (yes-associated protein) YAP Yap protein kinase LATS (large tumor suppressor kinase) peripheral nerve sheath tumor signal cross-talk stem cell skin development STK38 tumorigenesis NDR schwannoma G protein-coupled receptor anti-cancer therapy feedback loops vascular mimicry castration resistance chromatin Hippo signalling ECM MST prostate cancer TEAD cancer zebrafish |
| ISBN | 3-03921-777-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Disease and the Hippo Pathway |
| Record Nr. | UNINA-9910367742003321 |
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Hansen Carsten Gram
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Head and Neck Critical Illness : Basic and Clinical Research Implications
| Head and Neck Critical Illness : Basic and Clinical Research Implications |
| Autore | Tomita Hiroyuki |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (258 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
BDNF
Brain-Derived Neurotrophic Factor navigation spatial processing trauma trauma processing Post-Traumatic Stress Disorder PSTD allocentric hippocampus sinonasal tract malignant tumor CT MRI neuropsychiatric presentation of encephalitis paraneoplastic encephalitis autoimmune encephalitis infectious encephalitis diffuse large B-cell lymphoma canaloplasty non-perforating surgical procedures corticosteroid-induced glaucoma Schlemm’s canal neck mass diffusion-weighted MRI apparent diffusion coefficient procalcitonin bacterial meningitis viral meningitis antibiotic therapy biomarker differential diagnosis human papillomavirus human cancer head and neck reduction therapy head and neck squamous cell carcinoma (HNSCC) neutrophil-to-lymphocyte ratio (NLR) myeloid-derived suppressor cells (MDSC) aldehyde dehydrogenase 1 (ALDH1) prognosis prodigiosin doxorubicin priming influx autophagy cervical cellulitis abscess deep neck infection diabetes mellitus MAP1LC3B SQSTM1 subsites tumorigenesis oral cancer Nox4 oral tongue cancer squamous cell carcinoma surgery head and neck squamous cell carcinoma HPV 11q13 gene amplification immunohistochemistry head and neck cancer radiotherapy neutrophil/lymphocyte ratio survival ZFAND4 ANUBL1 oral squamous cell carcinoma nucleotide excision repair genetic polymorphism concurrent chemoradiotherapy HNSCC MIF 4-IPP metabolism annexin A9 annexin A10 differentiation grade NGS |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Head and Neck Critical Illness |
| Record Nr. | UNINA-9910557535203321 |
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Tomita Hiroyuki
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
| Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment |
| Autore | Di Meo Sergio |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (236 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
CTCL
apoptosis cell viability c-FLIP XIAP artemisinin SH-SY5Y cells hippocampal neurons H2O2 AMPK pathway atherosclerosis sphingomyelin synthase 2 endothelial dysfunction endoplasmic reticulum stress β-catenin insulin resistance cancer cardiovascular disease neurodegenerative disorders exercise mitochondria oxidative stress PGC-1 Nrf2 UCPs ROS light DNA damage evolution D-box cavefish Spalax trimethylamine N-oxide cardiomyocytes cardiotoxicity mitochondrial membrane potential CORM-2 NADPH oxidase AP-1 HO-1 Renal cell carcinoma (RCC) reactive oxygen species (ROS) glutathione (GSH) metabolism cancer therapy clear cell RCC papillary RCC chromophobe RCC sarcopenia reactive oxygen species redox signaling antioxidant supplementation protein aggregation redox proteinopathy peroxiredoxins tumorigenesis ROS scavengers |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Physiological and Pathological Role of ROS |
| Record Nr. | UNINA-9910557430503321 |
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Di Meo Sergio
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Targeting STAT3 and STAT5 in Cancer
| Targeting STAT3 and STAT5 in Cancer |
| Autore | Moriggl Richard |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (578 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
multiple myeloma
STAT3 S3I-1757 nanoparticle CD38 siRNA/RNAi polyethylenimine PEI lipopolyplex siRNA delivery glioma glioblastoma STAT5 AKT ERK1/2 prolactin androgens prostate cancer knockout escape mechanisms stem/progenitor cells cell hierarchy cancer CD4+ T cells CD8+ T cells myeloid cells immune check point hepatitis C virus (HCV) cirrhosis hepatocellular carcinoma (HCC) endoplasmic reticulum (ER) stress oxidative stress (OS) unfolded protein response (UPR) microRNA-122 (miR-122) nuclear factor erythroid 2-related factor 2 (NRF2) signal transducer and activator of transcription 3 (STAT3) hepatocyte nuclear factor 4 alpha (HNF4A) solid cancers cell cycle apoptosis inflammation mitochondria stemness tumor suppression melanoma autoimmune disease immunotherapy tumor-immune cell interactions breast cancer PD-L1 M2 macrophages NK cells STAT3 inhibitor XIII hedging transaction costs dynamic programming risk management post-decision state variable cancer progression cancer-stem cell cytokine therapy resistance metastasis immunosuppression tumor microenvironment proliferation tyrosine kinase 2 JAK family of protein tyrosine kinases signal transducer and activator of transcription cytokine receptor signaling gain-of-function mutation tumorigenesis ADAM17 interleukin-6 trans-signaling epidermal growth factor receptor (EGF-R) shedding metalloprotease tumor necrosis factor alpha (TNFα) inflammation associated cancer colon cancer lung cancer SH2 domain mutations autosomal-dominant hyper IgE syndrome inflammatory hepatocellular adenomas T-cell large granular lymphocytic leukemia T-cell prolymphocytic leukemia growth hormone insensitivity syndrome nuclear pore complex nuclear transport receptors nucleocytoplasmic shuttling targeting tumor-associated macrophages adoptive T cell therapy immune suppression STAT transcription factors JAK STAT T-PLL T-cell leukemia meta-analysis STAT5B signaling small-molecule inhibitors cancer models companion animals comparative oncology pharmacological inhibitor STAT5 signaling chemotherapy resistance myeloid leukemia heat shock proteins chaperones stabilization targeted therapy ovarian cancer hematopoietic cancers therapeutic targeting pharmacological inhibitors mTOR Bone Marrow Failure Syndromes lymphocytes lymphoma T-cells RHOA NGS MPN JAK2 V617F neoplastic stem cells |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557623503321 |
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Moriggl Richard
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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