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Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing
| Bioprocess Systems Engineering Applications in Pharmaceutical Manufacturing |
| Autore | Pörtner Ralf |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (226 p.) |
| Soggetto topico |
Technology: general issues
History of engineering & technology |
| Soggetto non controllato |
clonal cell population
phenotypic diversity inoculum train uncertainty-based cell culture model biopharmaceutical manufacturing Escherichia coli hybrid modeling machine learning model-assisted DoE quality by design upstream bioprocessing surface plasmon resonance (SPR) bioprocess monitoring biosensor quality by design (QbD) process analytical technology (PAT) biotherapeutics production vaccines production CHO DP-12 computational fluid dynamics bioreactor characterization hydrodynamic gradients process development critical shear stress Kolmogorov length scale operational space sensors cell culture spectroscopy PAT smart biomanufacturing soft-sensor Adeno-associated virus transfection PEI continuous gene therapy microcarriers bioreactor transient expression spheroid strength β-cells diabetes shear stress-guided production hydrodynamic stress Gaussian processes Bayes optimization Pareto optimization multi-objective seed train Chinese hamster ovary cells cryopreservation monoclonal antibodies N−1 perfusion process intensification upstream processing |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595072803321 |
Pörtner Ralf
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Single Cell Analysis
| Single Cell Analysis |
| Autore | Santra Tuhin Subhra |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (254 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
single-cell RNA sequencing
cholestatic liver injury hepatocyte heterogeneity inflammation liver tissue repair single cell mass cytometry single cell proteomics non-small cell lung cancer three-dimensional tissue culture snRNA-seq RNA velocity cluster analysis cardiomyocytes seurat cell heterogeneity sarcoma single-cell analysis total mRNA level transcriptome size proteomics immunofluorescence immunohistochemistry protein genome biomedical applications commercialization protein characterization conventional approaches microfluidic technologies single cell infectious disease pathophysiology therapeutics diagnostics microfluidics single-cell cloning monoclonal cell lines single-neuron models mapping electrophysiological recording isolation therapy micro/nanofluidic devices microelectrode array transfection artificial intelligence localized high-risk prostate cancer circulating tumor cells three-dimensional (3-D) telomere profiling laser microdissection whole-exome genome sequencing somatic single nucleotide variants copy number alterations precision medicine |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557388703321 |
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Santra Tuhin Subhra
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications
| Synthetic Peptides and Peptidomimetics: From Basic Science to Biomedical Applications |
| Autore | Doti Nunzianna |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (274 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
polymers
peptidomimetics AFM transfection molecular modelling peptide α-helix hydrocarbon stapling ring-closing metathesis i,i + 1 staple X-ray structure deferoxamine RGD peptides integrins radiodiagnostics PET imaging retro-inverso peptides anticancer peptides drug delivery peptide antigens Aβ IAPP antimicrobial peptides peptides diagnostic ELISA microarray PET SPECT imaging diagnostic non-imaging diagnostic amphiphilic peptides non-viral gene delivery nanocarrier peptide self-assemblies stimuli responsive SARS-CoV-2 FRET molecular docking molecular dynamics MM-GBSA drug repurposing antiviral cancer cyclic peptide integrin αvβ3 ALOS4 melanoma fluorescent peptide environment-sensitive fluorophore peptide labeling luciferin membrane-binding peptide antimicrobial peptide antitumor peptide RGD peptide antiproliferative activity chirality conformational analysis density functional theory (DFT) ferrocene hydrogen bonds peptidomimetic X-ray protein–protein interactions (PPIs) voltage-gated Na+ (Nav) channels fibroblast growth factor 14 (FGF14) medium spiny neurons (MSNs) nucleus accumbens (NAc) neurotherapeutics cyclophilin A (CypA) apoptosis-inducing factor (AIF) human neuroblastoma SH-SY5Y cells staurosporine-mediated cell death AIF(370-394) peptide caspase-3 PARP antifungal antibacterial peptide-based therapies synthetic peptides |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Synthetic Peptides and Peptidomimetics |
| Record Nr. | UNINA-9910580210803321 |
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Doti Nunzianna
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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