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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cosmeceuticals from Medicinal Plants
| Cosmeceuticals from Medicinal Plants |
| Autore | Lall Namrita |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (178 p.) |
| Soggetto topico |
Science: general issues
Pharmacology |
| Soggetto non controllato |
cosmeceutials
medicinal plant anti-inflammatory acne (acne vulgaris) skin aging |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557230503321 |
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Lall Namrita
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural and Synthetic Bioactives for Skin Health, Disease and Management
| Natural and Synthetic Bioactives for Skin Health, Disease and Management |
| Autore | Chamcheu Jean Christopher |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (314 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
keratinocytes
rutin ascorbic acid UV radiation proteomics 3D cell culture borage oil triacylglycerol metabolism acyl-ceramide corneocyte lipid envelope epidermis anti-melanogenesis B16/F10 melanoma cell hydroxyoctadecadienoic acid Sorghum bicolor 3-isobutyl-1-methylxanthine mycosis fungoides atopic dermatitis cutaneous lymphomas cornified envelope proteins FLG microalgae Planktochlorella nurekis skin cells proliferation senescence holothuroids glycosaminoglycans inflammation ear-inflammation whey Lactobacillus helveticus melanin α-melanocyte-stimulating hormone tyrosinase tyrosinase-related protein 1 dopachrome tautomerase microphthalmia-associated transcription factor cosmetics black cumin Nigella sativa Thymocid® skin aging glycation collagen collagenase elastase melanogenesis cosmeceutical konjac glucomannan ultraviolet B human epidermal primary melanocytes human embryonic fibroblasts anti-inflammatory activity antioxidant activity Cornus officinalis molecular docking human high-affinity IgE receptors α-MSH UVB irradiation lotus seedpod extract epigallocatechin propolis skin matrix metalloproteinase-1 UV phosphoinositide 3-kinase skin care skin health bioactive substances phytonutrients antioxidants nutraceuticals Perilla frutescens cell proliferation ultraviolet radiation DNA repair Lactobacillus plantarum CJLP55 acne vulgaris sebum hydration urine bacterial extracellular vesicles fungal infections nanohydrogel polysaccharide essential oils eggshell membrane keratinocyte differentiation TRPV skin thickness Lithospermum erythrorhizon NC/Nga Th1 Th2 Th17 Th22 immune balance skin barrier function |
| ISBN | 3-0365-6068-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639996003321 |
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Chamcheu Jean Christopher
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease
| The Effect of Calorie Restriction and Intermittent Fasting on Health and Disease |
| Autore | Chung Hae-Young |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (186 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Food & society |
| Soggetto non controllato |
calorie restriction diet
body mass reduction insulin IGF-1 leptin adiponectin malnutrition heart impairment papillary muscle assay calcium transient proteins SERCA2a L-type calcium channel aging autophagy calorie restriction (CR) CR mimetic calorie restriction FoxO transcription factor sirtuin neuropeptide Y pleiotropy of CR genes senescence-associated secretory phenotype senoinflammation mimetics intermittent fasting fat mass insulin secretion pancreatic islet lifespan longevity fasting skin aging photoaging skin appendages caloric restriction fatty acid biosynthesis mitochondrial biogenesis adipocyte |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557124303321 |
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Chung Hae-Young
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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