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Molecular Therapies for Inherited Retinal Diseases
| Molecular Therapies for Inherited Retinal Diseases |
| Autore | Collin Rob W.J |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
induced pluripotent stem cell (iPSC)
clustered regularly interspaced short palindromic repeats (CRISPR) homology-directed repair (HDR) Enhanced S-Cone Syndrome (ESCS) NR2E3 AAV retina gene therapy dual AAV gold nanoparticles DNA-wrapped gold nanoparticles ARPE-19 cells retinal pigment epithelium clathrin-coated vesicles endosomal trafficking retinitis pigmentosa autosomal dominant G56R putative dominant negative effect gapmer antisense oligonucleotides allele-specific knockdown Leber congenital amaurosis and allied retinal ciliopathies CEP290 Flanders founder c.4723A > T nonsense mutation Cilia elongation spontaneous nonsense correction AON-mediated exon skipping microRNA photoreceptors rods cones bipolar cells Müller glia retinal inherited disorders retinal degeneration antisense oligonucleotides Stargardt disease inherited retinal diseases splicing modulation RNA therapy ABCA4 iPSC-derived photoreceptor precursor cells cyclic GMP apoptosis necrosis drug delivery systems translational medicine Usher syndrome Leber congenital amaurosis RPE65 nonprofit patient registry translational protein trafficking protein folding protein degradation chaperones chaperonins heat shock response unfolded protein response autophagy therapy IRD DNA therapies RNA therapies compound therapies clinical trials Retinitis Pigmentosa GTPase Regulator adeno-associated viral Retinitis Pigmentosa (RP) choroideremia REP1 inherited retinal disease treatment apical polarity crumbs complex fetal retina PAR complex retinal organoids retinogenesis gene augmentation adeno-associated virus (AAV) |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674051103321 |
Collin Rob W.J
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Retina in Health and Disease
| The Retina in Health and Disease |
| Autore | Ptito Maurice |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (465 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
eye
retina development vascularization hypoxia autophagy programmed cell death cellular senescence retinogenesis altricial bird species precocial bird species senescence-associated galactosidase activity diabetes mellitus retinopathy microvascular complication optical coherence tomography angiography black African-American systemic disease biomarker retinal degenerative diseases mesenchymal stem cells stem cell therapy experimental models clinical trials AMD age-related macular degeneration trichostatin A (TSA) HDAC histone deacetylase vascular endothelial growth factor (VEGF) retinal degeneration endoplasmic reticulum stress response unfolded protein response GRP78 retinal glial cell diabetic retinopathy zebrafish neurovascular unit microvascular complications and dysfunction metabolism motor protein myosin 1C photoreceptor rhodopsin outer segments visual function macroglia astrocytes Müller cells optic nerve crush retinal ganglion cells spinal cord injury signal transducer and activator of transcription 3 epidermal growth factor Drp1 apoptosis mitochondria microglia neurodegeneration multiple sclerosis retinal microglia microglia morphotype light damage functional analysis early detection remodeling lactate GPR81 HCAR1 growth cone dLGN axon 3,5-DHBA kallikrein-kinin system kinin receptors GFAP osteopontin retinal detachment diabetes antioxidants bioenergetics respiration ATP glucagon-like peptide-1 exendin-4 catalase immunohistochemistry electron microscopy Charles Bonnet syndrome EEG visual hallucination resting state high-fat diet gut microbiome gut-retina axis RNA sequencing germ-free mice complement cascade angiogenesis retinal inflammation AII amacrine cell Prox1 parvalbumin gap junction eccentricity ON/OFF asymmetry arterioles betulinic acid ischemia-reperfusion injury reactive oxygen species retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer's disease optic neuritis oxidative stress neuroprotection fingolimod iPSC-RPE retinal pigment epithelium immunodeficient RCS rat ultrathin parylene retinal transplantation CD4+CD25+ inflammation iPSC typical cannabinoid receptors atypical cannabinoid receptors electroretinography monkeys visual system eye inflammation lipopolysaccharide natural bioactive extracts Ac2-26 FPR receptor inflammatory mediators retinal light injury LED screen optical filter retinal protection regeneration progenitor cell hyperglycemia photoreceptors neurod Notch |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557336603321 |
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Ptito Maurice
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||