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Advanced Therapy Medicinal Products for Eye Diseases: Goals and Challenges
| Advanced Therapy Medicinal Products for Eye Diseases: Goals and Challenges |
| Autore | Diebold Yolanda |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (207 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
MPC polymer
dry eye ocular surface lacrimal fluid mucin 3D bioprinting cornea retina ophthalmology tissue regeneration electrospinning conjunctiva decellularized tissue matrix small intestinal submucosa urinary bladder matrix polycaprolactone fiber tissue engineering stratification conjunctival epithelial cells hydrogel keratoplasty scaffold collagen advanced therapy medicinal product ATMP cell therapy gene therapy eye ocular regulatory marketing authorization double-crosslinking carbodiimide glutaraldehyde sodium metabisulfite sodium borohydride EDC/NHS stem cells retinal diseases optic nerve diseases cell replacement cell sources advanced therapies ocular mucosa blindness CLET limbal niche limbal stem cell LSCD mesenchymal stem cell transplantation MSCT corneal limbus decellularized xenograft recellularization mesenchymal stem cells |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Advanced Therapy Medicinal Products for Eye Diseases |
| Record Nr. | UNINA-9910557675503321 |
Diebold Yolanda
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Age-Related Macular Degeneration and Diabetic Retinopathy
| Age-Related Macular Degeneration and Diabetic Retinopathy |
| Autore | Westenskow Peter D |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
subthreshold micropulse laser
577-nm laser laser fixed parameters diabetic retinopathy diabetic macular edema optical coherence tomography autofluorescence real-life diabetic macular oedema visual prognosis indicators personalized medicine age-related macular degeneration choroidal neovascularization classification machine learning type 2 diabetes retinopathy ethnicity general practice risk factors progression glycemic gap glucose variability ETDRS classification biomarkers phenotypes anti-vascular endothelial growth factor diabetic retinopathy severity scale panretinal leakage index neovascular age-related macular degeneration anti-VEGF therapy retinal thickness visual acuity variability leakage index microaneurysms intravitreal aflibercept neovascularization ultra-widefield fluorescein angiography retinal imaging quantitative biomarkers precision medicine autoantibodies AT1-receptor PAR1 VEGF-A VEGF-B VEGF-receptor 2 AMD complement system semi-quantitative multiplex profilin mass spectrometry C4 vitronectin factor I genetic variants metabolites HDL central area thickness biomarker microRNA anti-VEGF retina edema OCT tomography microphysiological systems blood-neural barriers neurovascular unit disease modeling 3D models organ-on-a-chip inner blood-retinal barrier |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576879403321 |
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Westenskow Peter D
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday
| Chemical Biology of Sterols, Triterpenoids and Other Natural Products: A Themed Issue in Honor of Professor W. David Nes on the Occasion of His 65th Birthday |
| Autore | Guo De-an |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (256 p.) |
| Soggetto non controllato |
high-fat high-carbohydrate diet
toxicity oxysterol squalene cyclase sterol content sterolomics Polystichum Smith-Lemli-Opitz syndrome antifungals alkaloid cycloartenol synthase degeneration phytosterol Rhizopus arrhizus fibroblasts pod-blast fern cholesterol cytotoxic activity N-methylpiperidine. reductive deamination genetic disease isoprenoid steroid atherosclerosis granatane antioxidant wound healing development enzyme-assisted derivatization maturity terpene keratinocytes C4-demethylation complex (C4DMC) ?-sitosterol mesocarp sterol biosynthesis mechanism-based inactivators Mucorales gas chromatography-mass spectrometry (GC-MS) Girard reagent ROS sterol pattern N-methylcadaverine ?-tocopherol electrospray ionization-mass spectrometry human African trypanosomiasis HUVECs lipidomics campesterol triterpene oxyphytosterol leishmania Chagas disease LOX-1 sterol C24-methyltransferase antifungal effectivity ergosterol biosynthesis hormone glucose homeostasis retina solanaceae cholestanoic acid algal sterols cell migration withanolides insulin resistance Zingiber officinale posaconazole synthesis pre-diabetes pharmacognosy sterol 4-methylsterol oleanolic acid antiparasitic drugs lupeol oilseed aurelianolides divalent metal co-factor ligation bile alcohol phytosterols azoles infectious disease gingerols UV-radiation oil bodies ZnO sterol 14?-demethylase stigmasterol |
| ISBN | 3-03897-417-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Chemical Biology of Sterols, Triterpenoids and Other Natural Products |
| Record Nr. | UNINA-9910346835903321 |
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Guo De-an
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Diagnosis, Treatment and Prevention of Age-Related Macular Degeneration
| Diagnosis, Treatment and Prevention of Age-Related Macular Degeneration |
| Autore | Kodjikian Laurent |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (246 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
aflibercept monotherapy
polypoidal choroidal vasculopathy neovascular age-related macular degeneration good baseline visual acuity ForeseeHome AMD Monitoring System® AREDS2-HOME study age-related macular degeneration exudation optical coherence tomography angiography anti-vascular endothelial growth factor brolucizumab epithelial tear optical coherence tomography Sorsby's fundus dystrophy Sorsby hereditary retinal dystrophy choroidal neovascularisation macular neovascularization anti-VEGF treatment long-term FU treatment outcome emerging treatment neovascular age-related macular degeneration (nAMD) Vascular Endothelial Growth Factor (VEGF) cataract surgery clinical trials real-world evidence AMD oct-angiography fellow eye choriocapillaris quiescent macular neovascularization ranibizumab aflibercept anti-VEGF visual acuity reading acuity disease activity treatment change treat and extend switch therapy retina choroidal neovascularization angiogenesis meteorin therapeutic innovation prevention nutrients lifestyle treatment-naive cardiovascular risk factors arterial hypertension macula-off rhegmatogenous detachment superficial perifoveal capillary plexus retinal deep perifoveal capillary plexus identification risk Delphi STARS® food supplement bevacizumab meta-analysis meta-regression age-related macular degeneration (AMD) comparative therapies effectiveness intravitreal anti-vascular endothelial growth factor treat-and-extend pro re nata regimen |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566469403321 |
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Kodjikian Laurent
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Emerging Mechanisms in Neuronal Signaling: from Cell Biology to Pathogenesis
| Emerging Mechanisms in Neuronal Signaling: from Cell Biology to Pathogenesis |
| Autore | Eduardo Guido Mario |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (454 p.) |
| Soggetto topico |
Science: general issues
Neurosciences |
| Soggetto non controllato |
lipid signaling
neurodegeneration retina metabolism cell signaling oxidative stress transcription factors developmental disorders |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Emerging Mechanisms in Neuronal Signaling |
| Record Nr. | UNINA-9910557394703321 |
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Eduardo Guido Mario
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Genetic Testing for Rare Diseases
| Genetic Testing for Rare Diseases |
| Autore | Millán José |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (144 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
retina
inherited retinal diseases syndrome Turner syndrome mosaicism ring chromosomes growth hormone deficiency pituitary microadenoma clinical genetics early onset ataxia dystonia neurodevelopment network analysis bioinformatics ataxia phenotype child NGS next generation sequencing inborn errors of metabolism lysosomal disorders neuromuscular disease genetic testing whole exome sequencing Prader-Willi syndrome imprinting disorder recombinant human growth hormone insulin-like growth factor 1 HMGLD HMGCL HMG-CoA lyase deficiency inherited metabolic diseases familial hearing loss multiple diagnoses non-syndromic hearing loss ACTG1 MYH9 genetic counselling rare diseases professional recognition hearing loss genetic diagnosis SLC26A4 DFNB4 Tuvinians Altaians Southern Siberia Russia GSDME DFNA5 single-exon CNV |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566479203321 |
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Millán José
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondrial Dysfunction in Aging and Diseases of Aging
| Mitochondrial Dysfunction in Aging and Diseases of Aging |
| Autore | Haas Richard H |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto non controllato |
age-related diseases
sphingolipids glaucoma ALS neurodegeneration mitochondrial dysfunction adaptive immunity senescence de-emergence innate immunity cell danger response mitochondrial transfer axonal transport cytokines mitochondrial age-related macular degeneration prevention heart failure purinergic signaling autophagy Alzheimer's disease diabetic retinopathy proteostasis 1 immunosenescence Miro1 ROS metabolism optic nerve polypharmacy eIF2? Parkin coenzyme Q10 neurodegenerative disease DNA damage skin exercise nucleotide metabolism pasteur effect stress response inflammation retina drug-induced mitochondrial toxicity neuroinflammation exosomes reactive oxygen species 25(OH)D cardiomyopathy crabtree effect insulin resistance cardiovascular disease ageing genetic mutations metabokines mitochondria multiple sclerosis aerobic healing cycle SOD1 mitophagy PINK1 type 2 diabetes integrated cell stress response morbidity and mortality ultraviolet photoageing cancer aging 25(OH)2D lysosome NAD+ Parkinson's disease |
| ISBN | 3-03921-328-8 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367756303321 |
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Haas Richard H
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Therapies for Inherited Retinal Diseases
| Molecular Therapies for Inherited Retinal Diseases |
| Autore | Collin Rob W.J |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (262 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
induced pluripotent stem cell (iPSC)
clustered regularly interspaced short palindromic repeats (CRISPR) homology-directed repair (HDR) Enhanced S-Cone Syndrome (ESCS) NR2E3 AAV retina gene therapy dual AAV gold nanoparticles DNA-wrapped gold nanoparticles ARPE-19 cells retinal pigment epithelium clathrin-coated vesicles endosomal trafficking retinitis pigmentosa autosomal dominant G56R putative dominant negative effect gapmer antisense oligonucleotides allele-specific knockdown Leber congenital amaurosis and allied retinal ciliopathies CEP290 Flanders founder c.4723A > T nonsense mutation Cilia elongation spontaneous nonsense correction AON-mediated exon skipping microRNA photoreceptors rods cones bipolar cells Müller glia retinal inherited disorders retinal degeneration antisense oligonucleotides Stargardt disease inherited retinal diseases splicing modulation RNA therapy ABCA4 iPSC-derived photoreceptor precursor cells cyclic GMP apoptosis necrosis drug delivery systems translational medicine Usher syndrome Leber congenital amaurosis RPE65 nonprofit patient registry translational protein trafficking protein folding protein degradation chaperones chaperonins heat shock response unfolded protein response autophagy therapy IRD DNA therapies RNA therapies compound therapies clinical trials Retinitis Pigmentosa GTPase Regulator adeno-associated viral Retinitis Pigmentosa (RP) choroideremia REP1 inherited retinal disease treatment apical polarity crumbs complex fetal retina PAR complex retinal organoids retinogenesis gene augmentation adeno-associated virus (AAV) |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674051103321 |
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Collin Rob W.J
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neuronal Development and Degeneration
| Neuronal Development and Degeneration |
| Autore | Zhang Wenbo |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (161 p.) |
| Soggetto topico |
Science: general issues
Neurosciences |
| Soggetto non controllato |
neuronal development
degeneration retina brain neurodegenerative disease |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557207603321 |
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Zhang Wenbo
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nutrition and Eye Health
| Nutrition and Eye Health |
| Autore | Downie Laura |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (242 p.) |
| Soggetto non controllato |
polyphenols
crocin chyrsin glaucoma dietary assessment photoreceptor degeneration dry eye RR-zeaxanthin nutritional supplements drug discovery corneal neovascularization (CNV) AMD dietary antioxidants micronutrients age-related macular degeneration preclinical models lenses microvascular lesions cyclooxigenase-2 (COX-2) angiogenesis fish oil macrophage anti-oxidant vascular endothelial growth factor (VEGF) rosmarinic acid visual cycle diabetic retinopathy lutein gut-retina axis light damage crocetin supplements clinical practice guidelines nutrition light eye disease dietary habits flavonoids phytoconstituents saffron carotenoids fatty acid electroretinography lens advanced glycation end products interleukin-1? (IL-1?) mesozeaxanthin (RS zeaxanthin) endoplasmic reticulum stress omega-3 polyunsaturated fatty acids clinical survey corneal chemical burn reduced glutathione omega-3 AGREE II retina inflammation anti-inflammatory retinal pigment epithelium diet Lactobacillus paracasei KW3110 Crocus Sativus L. saponins cataract CODS neoangiogenesis estrogen-deficient rats food frequency questionnaire gut microbiota antioxidant supplements sinapic acid personalised medicine systematic reviews nuclear factor-kappaB (NF-?B) diabetes Cucurbita argyrosperma oxidative stress endoplasmic reticulum |
| ISBN | 3-03921-991-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910372786403321 |
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Downie Laura
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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