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A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder
| A Personalized Medicine Approach to the Diagnosis and Management of Autism Spectrum Disorder |
| Autore | Frye Richard E |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (416 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
fecal metabolites
ASD microbiome gastrointestinal symptoms Fisher Discriminant Analysis digital biomarkers wearables time series analysis autism social dyads socio-motor parameters network connectivity non-linear complex dynamics stochastic analysis autism spectrum disorders copy number variants females Array-Comparative Genomic Hybridization (Array-CGH) autism spectrum disorder Ehlers-Danlos syndrome hypermobility spectrum disorders autonomic disorder mast cell activation syndrome genetic testing chromosomal microarray analysis whole exome sequencing whole genome sequencing clinical utility polygenic risk scores Temple Grandin biomarker omics precision medicine proteomics transcriptomics epigenetics metabolomics patient stratification mitochondria oxidative stress prenatal environment immune dysfunction immunoglobulin G intravenous immunoglobulin energy metabolism fatty acid oxidation acyl-carnitines resveratrol integrative model concomitant condition disorder autism spectrum disorder (ASD) genomics personalized treatment strategy single nucleotide polymorphisms clinical decision support tool ADHD PANDAS OCD anxiety folate receptor alpha folates pregnancy brain development fetal development cobalamin glutathione methylation methylcobalamin redox metabolism locked-in network syndrome resting-state functional magnetic resonance imaging temporal lobe epilepsy amygdala brain COVID-19 children cytokines flavonoids inflammation luteolin mast cells microglia SARS-CoV-2 stress nutraceuticals survey vitamins minerals B12 folinic acid quality of life parents intervention systematic review medical claims logistic regression analysis retrospective analysis associated risk monoamine neurotransmitters neurotransmitter deficiency cerebral folate deficiency folate receptor alpha autoantibodies leucovorin α-amylase cortisol heart rate variability neuromodulation sleep anxiety transdermal electrical neuromodulation neurostimulation |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595075503321 |
Frye Richard E
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery
| Advances in Mucoadhesive Polymers and Formulations for Transmucosal Drug Delivery |
| Autore | Khutoryanskiy Vitaliy |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (206 p.) |
| Soggetto non controllato |
chitosan
maltodextrin Caco-2 cells alkyl lactate mucosal drug delivery thermogelling polymers buccal mucosa drug delivery drug delivery triple co-culture model oral lichen planus mucoadhesive polymers cyclodextrins paediatric mucoadhesion nanoparticles pectin furosemide oral lyophilisates films wound healing pluronic f127 interpolymer complexes transmucosal permeations Alzheimer’s disease biocompatibility poly (vinylpyrrolidone) mucosal membranes scanning electron microscopic images pioglitazone hydrogel resuspendibility thermoresponsive polymers mucoadhesive microspheres trimethyl chitosan Candida albicans xanthan gum omeprazole texture profile analysis acrylated chitosan mucoadhesive clotrimazole clobetasol Carbopol® hydroxypropyl cellulose electrospinning chitosan derivatives in vitro permeability l-arginine resveratrol cytotoxicity retention thiolated hyaluronic acid Carbopol mucoadhesive polymer rheology Eudragit® E PO detachment force chitosan-catechol controlled release PLGA-PEG liposphere gellan gum storage and loss moduli thiolated chitosan interpolyelectrolyte complex poly(2-ethyl-2-oxazoline) |
| ISBN | 3-03928-753-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910404086403321 |
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Khutoryanskiy Vitaliy
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (452 p.) |
| Soggetto non controllato |
HDACs
transcription epigenetics spermatozoa par complex A769662 MDCK skeletal muscle AID phosphorylation energy metabolism monocytes autophagy CML liver hindlimb suspension pregnancy preeclampsia gestational diabetes mellitus CaMKK2 assisted reproduction techniques nutrient-sensing signals sonic hedgehog protein acetylation glycogen storage disease AMPK adenosine monophosphate-activated protein kinase AICAR indirect calorimetry IL-1? MyHC I(?) HDAC4/5 endothelial cells infection hepatocyte p70S6K lipid metabolism host defense exercise kidney disease heat shock protein ?RIM mycobacteria activation loop developmental origins of health and disease (DOHaD) CREB TAK1 metabolic-inflammation phenylephrine AMP-activated protein kinase (AMPK) KATs 2-methoxyestradiol DNA methylation NLRP3 pump ?-linker steatosis AMPK kinase stress endothelial nitric-oxide synthase vasodilation adherent junctions epithelial cells glycogen Akt synaptic activation cellular energy sensing glucose uptake transporter co-expression atrophy nutrigenomics motility vasoconstriction fatty acid oxidation oxidative stress AS160 membrane histone modification sirtuin 1 (SIRT1) chromatin remodeling insulin signalling dietary fatty acids ULK CMML adaptive thermogenesis mTOR MDS mechanical unloading AML endothelial function medulloblastoma PKA adipose tissue NAD+ membranes nutrition ZO-1 TBC1D4 adipocyte soluble Adenylyl cyclase metabolism renin-angiotensin system energy utilization proteasome differentiation signaling peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) hypertrophy AMP-activated protein kinase metabolic disease LKB1 soleus muscle macrophages Immediate early genes CBS benign motor endplate remodeling ionomycin nectin-afadin tight junctions resveratrol protein kinase B regrowth mitochondria protein synthesis energy deficiency catechol-O-methyltransferase fiber-type microarrays carrier acetyl-CoA hypertension 3T3-L1 hypothalamus food intake |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
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Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Antitumor and Anti-HIV Agents from Natural Products
| Antitumor and Anti-HIV Agents from Natural Products |
| Autore | Nakagawa-Goto Kyoko |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (338 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
natural phaeosphaeride A
antitumor activity human tumor cell lines HEF cell line acute toxicity aspidosperma-type monoterpenoid indole alkaloids antiproliferative activity tubulin inhibitor Bousigonia mekongensis ursolic acid DOTA triterpenoids cytotoxicity diterpenoid alkaloids human tumor cells lipojesaconitine delcosine delpheline kobusine pseudokobusine BRAF inhibitor Mentha aquatica var. Kenting Water Mint essential oil chemoprevention two-stage skin carcinogenesis melanoma curcumin analog apoptosis oxidative stress drug–drug interaction tamoxifen taxol cisplatin Artemisia absinthium L. antioxidants total phenolic content melanoma and breast cancer cell line HaCaT cells inflammation breast cancer cell cycle flavonoids reactive oxygen species tumor suppression antiretroviral agents anti-HIV marine metabolites natural products drug development Ivalin Carpesium divaricatum hepatocellular carcinoma mitochondria-mediated apoptosis NF-κB Hernandia nymphaeifolia butanolides lignan glycosides coumarins antiangiogenic cancer natural agents chemistry medicine cancer stem cell cervical cancer pterostilbene resveratrol caffeic acid cancer multidrug resistance P-glycoprotein phenolic acid oxypeucedanin Angelica dahurica antiproliferation G2/M phase cell cycle arrest p53 SK-Hep-1 hepatoma cells allyl isothiocyanate benzyl isothiocyanate sulforaphane phenethyl isothiocyanate bladder cancer quercetin oral squamous cell carcinoma cells metastasis cell cycle arrest epithelial-to-mesenchymal transition matrix metalloproteinase transforming growth factor-β1 β-lapachone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557504803321 |
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Nakagawa-Goto Kyoko
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Benefits of Resveratrol Supplementation
| Benefits of Resveratrol Supplementation |
| Autore | Fernandez-Quintela Alfredo |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto non controllato |
polyphenols
?-viniferin leptin resistance p53 kidney energy restriction grape powder extract cytokines phosphorylation obesity energy metabolism metabolic pathways endothelial function polyol pathway antioxidant caloric restriction rat adipose tissue microparticles pathways angiotensin converting enzyme 2 resistance esRAGE interleukins metabolic syndrome dissolution rate thermogenesis streptozotocin bioavailability solubility metabolism renin-angiotensin system microbiota Sirt-1 magnesium dihydroxide hypertrophy metabolic diseases physiological adaption red wine extract lens distribution MTA1 sirtuin inflammation cardiac function rats cisplatin resveratrol mitochondria breast cancer ischemia-reperfusion cardiovascular metabolites gut microbiota prostate cancer performance type 2 diabetes cafeteria diet high-fat high-sucrose diet resistance exercise aging diabetes oxidative stress |
| ISBN | 3-03921-276-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346854603321 |
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Fernandez-Quintela Alfredo
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Benefits of the Mediterranean Diet-Wine Association: Role of Components
| Benefits of the Mediterranean Diet-Wine Association: Role of Components |
| Autore | Silva Paula |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (208 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
apigenin
docosahexaenoic acid eicosapentaenoic acid 7-ketocholesterol α-linolenic acid Mediterranean diet N2a cells oleic acid oxidative stress quercetin resveratrol wine ethanol acetaldehyde oral cavity cancer carcinogenesis polydatin peonidin 3-O-glucoside malvidin 3-O-glucoside quercetin 3-O-glucoside (+)-catechin (+)-taxifolin apoptosis neuronal death cerebellum polyphenols flavonoids diet clinical trials metabolites resveratrol butyrate ester butyric acid Steglich esterification prevent fat accumulation wine intake cardiovascular disease cancer dementia red wine extract AMD retinal cells ARPE-19 degenerative diseases ocular diseases olive oil alcohol phytochemicals tyrosol inflammatory bowel disease Crohn's disease ulcerative colitis inflammation neurodegeneration neuroprotection therapeutic targets pharmacology novel delivery system postovulatory aging oocyte quality reactive oxygen species |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti |
Benefits of the Mediterranean Diet—Wine Association
Benefits of the Mediterranean DietâWine Association |
| Record Nr. | UNINA-9910576886703321 |
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Silva Paula
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Bioactive Phytochemicals in Health and Disease
| Bioactive Phytochemicals in Health and Disease |
| Autore | Iriti Marcello |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (264 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
quercetin
nervous system molecular signals pharmacological potential cognitive impairment micronuclei radioprotectors radiation effects melanoma PNT2 B16F10 cells Ulmus parvifolia wound healing matrix metalloproteinase transforming growth factor skin rejuvenation kaempferol naringin orientin rutin vitexin chlorogenic acid citric acid malic acid quinic acid rosmarinic acid curcumin nanocurcumin neurological disorders nanocarriers liposomes cancer diet flavonoids food supplements hormesis phytoestrogens sulforaphane resveratrol cardiovascular disease nanomedicine liposome nanoformulation RNA-dependent RNA polymerase remdesivir chloroquine SARS-CoV-2 COVID-19 spike glycoproteins Acorus calamus ethnomedicinal phytochemistry toxicity pharmacological action clinical trial neuroprotective neurological metabolic application kurarinone coronavirus HCoV-OC43 autophagy infection MRC-5 cell LC3 p62/SQSTM1 protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557389003321 |
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Iriti Marcello
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biochemical Biomarkers and Neurodegenerative Diseases
| Biochemical Biomarkers and Neurodegenerative Diseases |
| Autore | Ciaccio Marcello |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (156 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
GLUT3
cerebral ischemia MCAO resveratrol astrocytes AMPK amyotrophic lateral sclerosis GSK3β neurodegenerative disease PD Arylsulfatase A lysosomes GWAS Gaucher's disease prognostic biomarker focused ultrasound MR-guided focused ultrasound high-intensity focused ultrasound ablation magnetic resonance imaging image quality stereotaxic techniques essential tremor Alzheimer's disease amyloid precursor protein Tyr682 residue YENPTY motif Fyn tyrosine kinase amyloid beta ALS biomarker beta amyloid AD biomarkers SARS-CoV-2 neuroinflammation neurodegenerative nisease nervous system Alzheimer's Disease Vitamin D 25(OH)D levels Vitamin D deficiency inherited neuromuscular disorders rare diseases multiple sclerosis genetic polymorphisms FOXP3 GATA3 vitamin D neuromelanin nigrosome-1 iron radiomics neurodegenerative diseases Parkinson's disease parkinsonian disorders |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557361103321 |
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Ciaccio Marcello
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biological Activities of Plant Food Components: Implications in Human Health
| Biological Activities of Plant Food Components: Implications in Human Health |
| Autore | Gentile Carla |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (168 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
resveratrol
bioactivities anticancer anti-obesity antidiabetes molecular mechanisms durum wheat bread Portulaca oleracea L. essential fatty acids omega-6/omega-3 ratio antioxidants Bangladesh vegetables polyphenols amylase glucosidase renin angiotensin-converting enzyme lipase mass spectrometry yeast antioxidant cytotoxicity bioavailability viability Punica granatum hydrolysable tannins flavonoids Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry tempura deep-fried product barley buckwheat Job's tears antioxidant capacity oil deterioration polyphenol oxidative stress necroptosis plant extract secondary metabolite γH2AX copper African food spices GC-MS (gas chromatography mass spectrometry) antimicrobial antibiofilm violacein inhibition swarming inhibition swimming inhibition anticholinesterase antiurease antityrosinase sensory analysis mineral content proanthocyanidins carotenoids antioxidant activity FRAP DPPH ABTS CAA |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Biological Activities of Plant Food Components |
| Record Nr. | UNINA-9910557529403321 |
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Gentile Carla
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cyanobacteria and Cyanotoxins: New Advances and Future Challenges
| Cyanobacteria and Cyanotoxins: New Advances and Future Challenges |
| Autore | Cameán Ana M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (246 p.) |
| Soggetto non controllato |
method validation
sirtuin 1 (SIRT1) arctic Cylindrospermopsin Microcystin-LR 16S rRNA gene astaxanthin secondary metabolites shotgun metagenomic sequencing time-resolved fluoroimmunoassay Histopathological evaluation cyanobacterial thresholds akinetes nutrient enrichment benthic mats cylindrospermopsin drinking water treatment plant blue-green algae supplements lettuce genotoxicity exposure bacterial community PCR microcystin-LR marine natural compounds ELISA [d-Leu1]Microcystin-LR Paracentrotus lividus tadpoles apoptosis 16S rRNA gene sequencing PSP toxins marine cyanobacteria hemolytic essay energy budget bioassays anatoxin-a Lithobates catesbeianus mixture reproductive toxicity cyanobacteria taste-and-odor compounds Procambarus clarkii drinking water saxitoxin resveratrol harmful algal blooms cytotoxicity phylogenetic analyses Yangtze estuary microcystin mutagenicity detection Artemia salina water source cyanotoxins microcystins in vitro marine sponges microcystin-LR (MC-LR) UPLC-MS/MS reservoir microbial metabolisms Aphanizomenon flos-aquae monoclonal antibody oxidative stress Nostocales |
| ISBN | 3-03921-839-5 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cyanobacteria and Cyanotoxins |
| Record Nr. | UNINA-9910404089003321 |
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Cameán Ana M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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