Info
- Utilizzare la checkbox di selezione a fianco di ciascun documento per attivare le funzionalità di stampa, invio email, download nei formati disponibili del (i) record.
In Silico Strategies for Prospective Drug Repositionings
| In Silico Strategies for Prospective Drug Repositionings |
| Autore | Udrescu Lucreția |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
COVID-19
drug repurposing topological data analysis persistent Betti function SARS-CoV-2 network-based pharmacology combination therapy nucleoside GS-441524 fluoxetine synergy antidepressant natural compounds QSAR molecular docking drug repositioning UK Biobank vaccine LC-2/ad cell line drug discovery docking MM-GBSA calculation molecular dynamics cytotoxicity assay GWAS multiple sclerosis oxidative stress repurposing ADME-Tox bioinformatics complex network analysis modularity clustering ATC code hidradenitis suppurativa acne inversa transcriptome proteome comorbid disorder biomarker signaling pathway druggable gene drug-repositioning MEK inhibitor MM/GBSA Glide docking MD simulation MM/PBSA single-cell RNA sequencing pulmonary fibrosis biological networks p38α MAPK allosteric inhibitors in silico screening computer-aided drug discovery network analysis psychiatric disorders medications psychiatry mental disorders toxoplasmosis Toxoplasma gondii in vitro screening drug targets drug-disease interaction target-disease interaction DPP4 inhibitors lipid rafts |
| ISBN | 3-0365-6133-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639987703321 |
Udrescu Lucreția
|
||
| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
State-of-Art in Innate Immunity
| State-of-Art in Innate Immunity |
| Autore | Fischer Silvia |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (188 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
inflammation
type I interferons interleukin-1β crosstalk hepatic non-parenchymal cells albumin chronic liver diseases bacteria cytomegalovirus endothelin receptor repurposing cell culture Drosophila suzukii hemocytes plasmatocytes extracellular traps HMGB1 RAGE TLR4 DAMP SIRT1 α7-nicotinic acetylcholine receptor nociceptor cancer COVID-19 proteostasis autoinflammation ribosomopathies proteinopathies proteasomopathies extracellular RNA cytokines macrophages endothelial cells toll-like receptors angiogenesis γδ T cells gamma delta T cells proliferation macrophage polarization neutrophils neutrophil extracellular traps NETs ischemia PANoptosis PANoptosome pyroptosis apoptosis necroptosis inflammatory cell death inflammasome innate immunity infection NLR caspase IRF1 ZBP1 RIPK1 RIPK3 MLKL NLRP3 AIM2 Pyrin caspase-1 ASC caspase-8 caspase-3 caspase-7 plasticity redundancy SMOC1 thrombin |
| ISBN | 3-0365-5324-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910619465003321 |
|
Fischer Silvia
|
||
| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy
| The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| Autore | Madureira Patrícia Alexandra Saraiva |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (307 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
hypoxia
macrophages colon cancer tumor microenvironment immune cell infiltration prognosis feline mammary carcinoma PD-1 PD-L1 CTLA-4 TNF-α biomarkers immunotherapy cancer histone modification inhibitor KDM5B molecular docking repurposing cancer acidity hyperosmolarity cross-presentation tumour microenvironment syngeneic model prostate cancer radiotherapy preclinical modelling myeloid-derived suppressor cells biomarker stroma cancer-associated fibroblast (CAF) extracellular matrix (ECM) cytokine/chemokine growth factors pro- and anti-tumor immune cells immunomodulatory roles radiotherapy dose fractionation radioresistance radiosensitivity breast cancer S100A10 (p11) tumor growth tumor progression metastasis carcinoma mammary gland triple negative pre-metastatic niche pro-inflammatory cytokines clinical trials evolutionary therapy darwinian evolution cancer cells subpopulations diclofenac koningic acid spheroid 3D co-culture microenvironment resistance myeloid cells cancer development molecular subtypes of pancreatic cancer chemotherapy response pancreatic stellate cells regulatory T cells tumor-associated macrophages myeloid derived suppressor cells glioblastoma (GB) Hypoxia Inducible Factor (HIF) glioma stem cells (GSC) oxidative stress reactive oxygen species plasmin plasminogen S100A10 uPA uPAR PAI-1 PAI-2 cancer stem cells cancer recurrence therapeutic resistance signaling pathways targeted therapy head and neck cancer lung cancer bladder cancer |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557354203321 |
|
Madureira Patrícia Alexandra Saraiva
|
||
| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||