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In Silico Strategies for Prospective Drug Repositionings
| In Silico Strategies for Prospective Drug Repositionings |
| Autore | Udrescu Lucreția |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (288 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
COVID-19
drug repurposing topological data analysis persistent Betti function SARS-CoV-2 network-based pharmacology combination therapy nucleoside GS-441524 fluoxetine synergy antidepressant natural compounds QSAR molecular docking drug repositioning UK Biobank vaccine LC-2/ad cell line drug discovery docking MM-GBSA calculation molecular dynamics cytotoxicity assay GWAS multiple sclerosis oxidative stress repurposing ADME-Tox bioinformatics complex network analysis modularity clustering ATC code hidradenitis suppurativa acne inversa transcriptome proteome comorbid disorder biomarker signaling pathway druggable gene drug-repositioning MEK inhibitor MM/GBSA Glide docking MD simulation MM/PBSA single-cell RNA sequencing pulmonary fibrosis biological networks p38α MAPK allosteric inhibitors in silico screening computer-aided drug discovery network analysis psychiatric disorders medications psychiatry mental disorders toxoplasmosis Toxoplasma gondii in vitro screening drug targets drug-disease interaction target-disease interaction DPP4 inhibitors lipid rafts |
| ISBN | 3-0365-6133-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910639987703321 |
Udrescu Lucreția
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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State-of-Art in Innate Immunity
| State-of-Art in Innate Immunity |
| Autore | Fischer Silvia |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (188 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
AIM2
albumin angiogenesis apoptosis ASC autoinflammation bacteria cancer caspase caspase-1 caspase-3 caspase-7 caspase-8 cell culture chronic liver diseases COVID-19 crosstalk cytokines cytomegalovirus DAMP Drosophila suzukii endothelial cells endothelin receptor extracellular RNA extracellular traps gamma delta T cells hemocytes hepatic non-parenchymal cells HMGB1 infection inflammasome inflammation inflammatory cell death innate immunity interleukin-1β IRF1 ischemia macrophage polarization macrophages MLKL n/a necroptosis NETs neutrophil extracellular traps neutrophils NLR NLRP3 nociceptor PANoptosis PANoptosome plasmatocytes plasticity proliferation proteasomopathies proteinopathies proteostasis Pyrin pyroptosis RAGE redundancy repurposing ribosomopathies RIPK1 RIPK3 SIRT1 SMOC1 thrombin TLR4 toll-like receptors type I interferons ZBP1 α7-nicotinic acetylcholine receptor γδ T cells |
| ISBN | 3-0365-5324-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910619465003321 |
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Fischer Silvia
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy
| The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy |
| Autore | Madureira Patrícia Alexandra Saraiva |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (307 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
3D co-culture
biomarker biomarkers bladder cancer breast cancer cancer cancer acidity cancer cells subpopulations cancer development cancer recurrence cancer stem cells cancer-associated fibroblast (CAF) carcinoma chemotherapy response clinical trials colon cancer cross-presentation CTLA-4 cytokine/chemokine darwinian evolution diclofenac evolutionary therapy extracellular matrix (ECM) feline mammary carcinoma glioblastoma (GB) glioma stem cells (GSC) growth factors head and neck cancer histone modification hyperosmolarity hypoxia Hypoxia Inducible Factor (HIF) immune cell infiltration immunomodulatory roles immunotherapy inhibitor KDM5B koningic acid lung cancer macrophages mammary gland metastasis microenvironment molecular docking molecular subtypes of pancreatic cancer myeloid cells myeloid derived suppressor cells myeloid-derived suppressor cells oxidative stress PAI-1 PAI-2 pancreatic stellate cells PD-1 PD-L1 plasmin plasminogen pre-metastatic niche preclinical modelling pro- and anti-tumor immune cells pro-inflammatory cytokines prognosis prostate cancer radioresistance radiosensitivity radiotherapy radiotherapy dose fractionation reactive oxygen species regulatory T cells repurposing resistance S100A10 S100A10 (p11) signaling pathways spheroid stroma syngeneic model targeted therapy therapeutic resistance TNF-α triple negative tumor growth tumor microenvironment tumor progression tumor-associated macrophages tumour microenvironment uPA uPAR |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557354203321 |
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Madureira Patrícia Alexandra Saraiva
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Toward Re-Entanglement : A Charter for the City and the Earth / / Philipp Misselwitz, Alan Organschi; ed. by Bauhaus Earth
| Toward Re-Entanglement : A Charter for the City and the Earth / / Philipp Misselwitz, Alan Organschi; ed. by Bauhaus Earth |
| Autore | Misselwitz Philipp |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Berlin : , : JOVIS, , [2024] |
| Descrizione fisica | 1 online resource (64 p.) |
| Collana | Bauhaus Earth Essays |
| Soggetto non controllato |
biodiversity
built environment climate collapse conservation ecology environmental crisis future buildings future cities future global climate catastrophe housing human habitats land restoration materials nature public space repurposing social crisis systematic regeneration urban consolidation |
| ISBN |
9783986120474
3986120475 |
| Classificazione | ZH 9317 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Frontmatter -- Introduction -- A Call to Action -- Why We Must Act -- What We Must Do -- 1. Invest in nature -- 2. Expand the system boundaries of design and governance, and the temporal and spatial scales of our agency -- 3. Enhance rather than deplete biodiversity -- 4. Sink carbon by construction -- 5. Capture natural energy rather than extracting fossil fuels -- 6. Question why we build and what we build with and prioritize the reuse of existing buildings and material -- 7. Build dense and poly-centric cities to restore urban community and regional wildlands -- 8. Provide homes for all people to build social equity, economic livelihood, and shared respect for our common resources -- 9. Make public space the essential infrastructure of cities and the site of sociopolitical discourse and innovation -- 10. Empower rural communities and engage the traditional knowledge and practices of Indigenous peoples and non-Western cultures -- 11. Welcome new urban citizens -- 12. Redefine beauty by building with love and compassion for humans and non-humans alike -- What We Need for Systemic Change and a Regenerative Future -- Coauthors -- Motivations and Reflections: Bridging Language and Action |
| Record Nr. | UNINA-9910904090103321 |
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Misselwitz Philipp
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| Berlin : , : JOVIS, , [2024] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Wiederverflechtungen : Eine Charta für unsere Städte und den Planeten / / Philipp Misselwitz, Alan Organschi; hrsg. von Bauhaus Earth
| Wiederverflechtungen : Eine Charta für unsere Städte und den Planeten / / Philipp Misselwitz, Alan Organschi; hrsg. von Bauhaus Earth |
| Autore | Misselwitz Philipp |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Berlin : , : JOVIS, , [2024] |
| Descrizione fisica | 1 online resource (64 p.) |
| Collana | Bauhaus Earth Essays |
| Soggetto topico | ARCHITECTURE / Urban & Land Use Planning |
| Soggetto non controllato |
biodiversity
built environment climate collapse conservation ecology environmental crisis future buildings future cities future global climate catastrophe housing human habitats land restoration materials nature public space repurposing social crisis systematic regeneration urban consolidation |
| ISBN |
9783986121556
3986121552 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | ger |
| Nota di contenuto | Frontmatter -- Einleitung -- Aufforderung zum Handeln -- Warum wir handeln müssen -- Was wir tun müssen -- 1. Investiert in die Natur -- 2. Erweitert die systemischen Grenzen von Design und Verwaltung sowie die Tragweite unseres zeitlichen und räumlichen Handelns -- 3. Fördert biologische Vielfalt, zerstört sie nicht -- 4. Nutzt Gebäude als Kohlenstoffspeicher -- 5. Nutzt Energie sparsam und minimiert fossile Brennstoffe -- 6. Umbau vor Neubau: Für eine konsequente Hinterfragung der gängigen Baupraxis -- 7. Erschafft dichte und polyzentrische Städte, um Urbanität und naturbelassene Räume wiederherzustellen -- 8. Sichert menschenwürdigen Wohnraum, soziale Gerechtigkeit, wirtschaftliche Existenz für alle und Respekt von unseren gemeinsamen Ressourcen -- 9. Gestaltet den öffentlichen Raum als Ort des gesellschaftspolitischen Diskurses und der Innovation -- 10. Stärkt ländliche Gemeinschaften und nutzt traditionelles Wissen und Praktiken indigener Völker und nicht-westlicher Kulturen -- 11. Begrüßt neue Stadtbewohner*-innen mit Wohlwollen -- 12. Prägt eine neue Ӓsthetik des Bauens- mit Liebe und Einfühlsamkeit für alle Lebewesen -- Was wir für den systemischen Wandel und eine regenerative Zukunft brauchen -- Co-Autor*innen -- Eine Reflexion über Sprache und die Brücke zum Handeln |
| Record Nr. | UNINA-9910904090003321 |
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Misselwitz Philipp
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| Berlin : , : JOVIS, , [2024] | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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