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Drug Metabolism/Transport and Pharmacokinetics
| Drug Metabolism/Transport and Pharmacokinetics |
| Autore | Song Im-Sook |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (232 p.) |
| Soggetto topico |
Medicine
Pharmaceutical industries |
| Soggetto non controllato |
tofacitinib
dose-dependent pharmacokinetics hepatic and intestinal first-pass effect rats catalposide in vitro human metabolism UDP-glucuronosyltransferase sulfotransferase carboxylesterase celecoxib drug–drug interaction fluorescence HPLC metabolism repaglinide HSG4112 anti-obesity agent stereoselectivity pharmacokinetics compound K protopanaxadiol (PPD) biliary excretion intestinal metabolism Carthamus tinctorius extract notoginseng total saponins comparative pharmacokinetic study large volume direct injection compatibility mechanism mertansine human hepatocytes cytochrome P450 UDP-glucuronosyltransferases sodium-glucose cotransporter 2 (SGLT2) inhibitors DWP16001 kidney distribution inhibition mode diabetes transporter-enzyme interplay influx transporter efflux transporter physiologically based pharmacokinetic model cytochrome P450 enzymes tiropramide healthy Korean subjects modeling population pharmacokinetic quercetin breast cancer resistance protein inhibitor prazosin sulfasalazine kinetic analysis food–drug interactions Caco-2 EpiIntestinal first-pass P-gp BCRP drug transporter CYP3A4 oral availability automatization drug absorption drug dosing head-and-neck cancer real-time measurements taxanes tissue engineering UHPLC-MS/MS metformin verapamil drug interaction organic cation transporter 2 renal excretion acute renal failure gentamicin cisplatin hepatic CYP3A1(23) creatinine clearance renal clearance nonrenal clearance |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607703321 |
Song Im-Sook
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations
| Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations |
| Autore | Ciarimboli Giuliano |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (248 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
transporters
endogenous metabolism functional subgroups SLC22 remote sensing and signaling drug transporters gut microbiome chronic kidney disease solute carrier 22 (SLC22) Remote Sensing and Signaling Theory interorgan communication organic anion transporter organic cation transporter SLC22A15 SLC22A16 SLC22A18 kidney Malpighian tubule TCGA human pathology atlas gene ontology organic cations transport kidneys regulation Nuclear receptor renal excretion bile acids organic cation transporters drug disposition genetic polymorphisms drug-induced kidney injury nephrotoxicity RA Tofacitinib Baricitinib MATE1 solute carrier (SLC) family OCT1 SLC22A1 species differences drugs pesticides cisplatin nephrotoxicity PPAR-alpha organic transporters serotonin transporter plasma membrane monoamine transporter ketamine isoflurane serotonin clearance antidepressant-like activity chronoamperometry tail suspension test forced swim test hepatotoxicity solute carrier pulmonary drug delivery SLC22A1-5 lung epithelium drug uptake β2-agonists chronic lung diseases anticholinergics trospium OCT MATE drug excretion drug transport |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557346203321 |
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Ciarimboli Giuliano
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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