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Genetics and Genomics of Pulmonary Arterial Hypertension
| Genetics and Genomics of Pulmonary Arterial Hypertension |
| Autore | Southgate Laura |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (188 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Genetics (non-medical) |
| Soggetto non controllato |
pulmonary arterial hypertension
massive parallel sequencing NGS digenic inheritance and genetics BMPR2 promoter pathogenic variant heritable pulmonary arterial hypertension genetic analysis NGS gene panel BMPR2 TBX4 GDF2 EIF2AK4 genomics pediatrics lung disease endothelial cells smooth muscle cells DNA damage DNA repair expression quantitative trait locus eQTL blood genetics exome sequencing molecular genetics paediatrics bone morphogenetic protein receptor type 2 heritable familial estrogen estradiol penetrance gender PAH forward phenotyping forward genetics reverse genetics reverse phenotyping intermediate phenotypes whole-genome sequencing epigenetic inheritance genetic heterogeneity phenotypic heterogeneity pulmonary hypertension bone morphogenetic protein receptor 2 signaling repurposed drugs pharmaceuticals miRNA clinical trials |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595078603321 |
Southgate Laura
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides
| Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides |
| Autore | Rubattu Speranza |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (212 p.) |
| Soggetto non controllato |
postmortem biochemistry
medulla animal models remodeling BNP PCSK9 guanylyl cyclase/natriuretic peptide receptor-A cardiorenal syndrome forensic medicine preserved ejection fraction kidney renin-angiotensin-aldosterone system atrial fibrillation vasopressor congestive heart failure atrial natriuretic peptide gene-knockout obesity heart failure angiogenesis adipose tissue vascular LDL receptor metabolic syndrome linkage analysis cardiometabolic disease cardiomyocyte cardiac dysfunction cardiac hypertrophy insulin lipid metabolism cGMP Idiopathic Pulmonary Arterial Hypertension (IPAH) Natriuretic Peptide Clearance Receptor (NPR-C) signaling gene-duplication renin–angiotensin system natriuretic peptides angiotensin receptor–neprilysin inhibitor cardiac remodelling ARNi NT-proBNP inflammation pulmonary arterial hypertension vascular homeostasis endothelial cell Atrial Natriuretic peptide natriuretic peptide vasodilator stroke genetic variants arterial hypertension fibroblast MANP hypertension guanylyl cyclase receptor A |
| ISBN | 3-03921-583-3 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Molecular Basis of Cardiovascular Diseases |
| Record Nr. | UNINA-9910367751403321 |
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Rubattu Speranza
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction
| Molecular Mechanisms in Pulmonary Hypertension and Right Ventricle Dysfunction |
| Autore | Karmouty-Quintana Harry |
| Pubbl/distr/stampa | Frontiers Media SA, 2019 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico |
Science: general issues
Physiology |
| Soggetto non controllato |
vascular remodeling
Smooth Muscle Cell endothelial cell hypoxia Fibrosis pulmonary arterial hypertension Mitochondria Bleomycin Inflammation Iron |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557237303321 |
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Karmouty-Quintana Harry
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| Frontiers Media SA, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Oligonucleotide, Therapy, and Applications
| Oligonucleotide, Therapy, and Applications |
| Autore | Aliño Salvador |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (123 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
quantum dots (QDs)
DNAzyme ROS Amplex Red light-induced activity DNA methylation histone code microRNA nanoparticles noncoding RNA pulmonary arterial hypertension aptamer aptasensor influenza SERS virus detection α-synuclein antisense oligonucleotide dopamine neurotransmission double mutant A30P*A53T* motor deficits Parkinson’s disease transgenic mouse model G-quadruplexes covalent dimer construct anti-proliferative activity primary cell culture of human glioma antisensense oligonucleotide Foxp3 regulatory T cells vaccine immunogenicity Sporothrix schenckii Marfan syndrome fibrillin-1 antisense oligonucleotides exon skipping splice-switching |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557615903321 |
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Aliño Salvador
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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PPARs as Key Mediators of Metabolic and Inflammatory Regulation
| PPARs as Key Mediators of Metabolic and Inflammatory Regulation |
| Autore | Vázquez-Carrera Manuel |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (456 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
nuclear receptor
gene transcription inflammation molecular docking PPARβ/δ lung pulmonary artery GW0742 GSK3787 docking lipopolysaccharide (LPS) PPARγ ligand coumarin fluorescent ligand screening crystal structure PPAR atopic dermatitis psoriasis metabolic reprograming glucose fatty acids mycobacteria M. tuberculosis M. leprae PPARs lipid droplets metabolic alterations hepatic damage nuclear factors pharmacological targets AMPK GDF15 insulin resistance type 2 diabetes mellitus peroxisome proliferator-activated receptor gamma (PPARγ) real-time PCR ELISA immunohistochemistry signaling pathway PPAR gamma brain neural stem cells infection neuroinflammation HIV Zika cytomegalovirus neurogenesis microglia liver damage toll-like receptor 4 P2Y2 receptor metabolic syndrome resveratrol quercetin PPARα peroxisome β-oxidation PPRE ligand coregulator micronutrients PPARα knockout adipose tissue browning lipid metabolism depression PPARg neuropathology corticotropin releasing hormone norepinephrine subgenual prefrontal cortex amygdala nucleus accumbens common carotid artery occlusion electroretinography fibroblast growth factor 21 pemafibrate peroxisome proliferator-activated receptor alpha retinal ischemia skeletal muscle substrate metabolism nonalcoholic fatty liver disease (NAFLD) sex dimorphism lipidomics hepatic sex-biased gene expression PPARγ pulmonary arterial hypertension TGFβ vascular injury proliferation kidney fibrosis pattern-recognition receptors phagocytosis nitric oxide synthase fenofibrate oleoylethanolamide palmitoylethanolamide cancer immunity obesity diabetes miRNA DNA methylation histone modification peroxisome-proliferator-activated receptor fatty acid oxidation doping control regulatory T cells exercise nuclear receptors nutrigenomics energy homeostasis dairy animals non-alcoholic fatty liver disease (NAFLD) non-alcoholic steatohepatitis (NASH) peroxisome proliferator-activated receptors (PPAR) bezafibrate fenofibric acid peroxisome proliferator-activated receptor dual/pan agonist X-ray crystallography |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576873703321 |
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Vázquez-Carrera Manuel
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations
| Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations |
| Autore | Ruaro Barbara |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (178 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
systemic sclerosis
scleroderma interstitial lung disease pulmonary function tests high-resolution computed tomography rheumatic pulmonary arterial hypertension targeted therapy systemic lupus erythematosus airway disease shrinking lung syndrome diffuse alveolar hemorrhage pleurisy infection cardiopulmonary exercise testing osteopontin connective tissue diseases pulmonary involvement microvascular involvement nailfold capillaroscopy rheumatoid arthritis interstitial lung diseases CX3CL1/fractalkine CX3CR1 M1 macrophage M2 macrophage SKG mice heart failure 3D-echocardiography ventricular function outcome ventricular-arterial coupling antifibrotic agents COVID-19 IPF progressive fibrosing ILD UIP pharmacological interactions fibromyalgia gastrointestinal symptoms probiotic VSL#3® efficacy tolerability polymyalgia rheumatica vagus nerve stimulation inflammatory response PMR t-vns |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Rheumatic Diseases |
| Record Nr. | UNINA-9910566486303321 |
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Ruaro Barbara
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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