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Aging and Age-Related Disorders : : From Molecular Mechanisms To Therapies / / Vladimir Titorenko
| Aging and Age-Related Disorders : : From Molecular Mechanisms To Therapies / / Vladimir Titorenko |
| Autore | Titorenko Vladimir |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (322 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
advanced glycated end products
microRNAs differentiation transcription skin absorption cellular quiescence lifespan longevity genes protein kinases self-renewal circadian blood-brain barrier aging-related disorders sirtuin-1 inflammation arterial aging reactive oxygen species electron microscopy reconstructed human skin rejuvenation low-dose fluvastatin and valsartan combination inflammaging hematopoietic stem cell aging cell cycle mitochondria ribose the nervous system nanomedicine proteostasis adult stem cells immunosenescence cell signaling mechanisms of quiescence maintenance metabolism aging melatonin diabetes mechanisms of quiescence entry and exit Drosophila melanogaster GSK3 (glycogen synthase kinase 3) |
| ISBN |
9783039213566
3039213563 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367567903321 |
Titorenko Vladimir
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondrial Dysfunction in Aging and Diseases of Aging / Richard H. Haas
| Mitochondrial Dysfunction in Aging and Diseases of Aging / Richard H. Haas |
| Autore | Haas Richard H |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (270 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
age-related diseases
sphingolipids glaucoma ALS neurodegeneration mitochondrial dysfunction adaptive immunity senescence de-emergence innate immunity cell danger response mitochondrial transfer axonal transport cytokines mitochondrial age-related macular degeneration prevention heart failure purinergic signaling autophagy Alzheimer's disease diabetic retinopathy proteostasis 1 immunosenescence Miro1 ROS metabolism optic nerve polypharmacy eIF2? Parkin coenzyme Q10 neurodegenerative disease DNA damage skin exercise nucleotide metabolism pasteur effect stress response inflammation retina drug-induced mitochondrial toxicity neuroinflammation exosomes reactive oxygen species 25(OH)D cardiomyopathy crabtree effect insulin resistance cardiovascular disease ageing genetic mutations metabokines mitochondria multiple sclerosis aerobic healing cycle SOD1 mitophagy PINK1 type 2 diabetes integrated cell stress response morbidity and mortality ultraviolet photoageing cancer aging 25(OH)2D lysosome NAD+ Parkinson's disease |
| ISBN |
9783039213283
3039213288 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367756303321 |
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Haas Richard H
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Basis and Gene Therapies of Cystic Fibrosis
| Molecular Basis and Gene Therapies of Cystic Fibrosis |
| Autore | Engelhardt John |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (210 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
airway basal cell
baculovirus biomarker CFTR CFTR gene CFTR modulators CFTR variants CFTR-related disorders common and new pathogenic variants cyclophosphamide cystic fibrosis Cystic fibrosis disease liability drug development enterotoxin gene cluster ethnic Russian population exosomes functional assay gene therapy genotype-guided therapy genotype-phenotype correlations gut-lung axis health policies health policy human nasal epithelial cells incidence insect cells interpretation lentivirus lung lung microbiome metagenomics microvesicles miRNA molecular diagnosis MRSA newborn screening next generation sequencing Next Generation Sequencing (NGS) organoids penetrance pre-clinical in vitro models primary cells proteostasis rAAV2/HBoV1 small molecules Staphylococcus aureus superantigen survival transcriptomics transient immunosuppression trypsinogen |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557392203321 |
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Engelhardt John
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Chaperones and Neurodegeneration
| Molecular Chaperones and Neurodegeneration |
| Autore | Cintia Roodveldt |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 online resource (180 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico | Neurosciences |
| Soggetto non controllato |
amyloid protein
heat-shock protein heat-shock response molecular chaperone neurodegeneration neurodegenerative disease neuroprotection protein misfolding proteostasis therapeutics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910261132603321 |
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Cintia Roodveldt
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Mechanism of Alzheimer's Disease / Ian Macreadie
| Molecular Mechanism of Alzheimer's Disease / Ian Macreadie |
| Autore | Macreadie Ian |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (228 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
HOTAIR
neurosciences sleep disturbance positron emission tomography (PET) vitamin B complex neurodegeneration Tau miR-15/107 default-mode network complement receptor 1 neuronal differentiation epigenetics brain glucose metabolism oligomerization genetic risk A?O receptors prion ryanodine receptor type 3 diabetes complement cognitive behavioral therapy for insomnia cognitive function epigenome-wide association study Alzheimer’s disease calcium signaling ?-secretase tau Prolyl isomerases NEAT1 complement C3b/C4b receptor proteostasis amyloid beta yeast slow-wave sleep amyloid ? nutrition 4 protein aggregation apolipoprotein E dementia MALAT1 inositol 1 lncRNAs molecular biology methylenetetrahydrofolate reductase MTHFR gene 5-trisphosphate receptor CR1 density miR-34c aggregation heat shock protein dendritic spine S-adenosylmethionine beta amyloid ion channel inflammation sleep fragmentation cystathionine-?-lyase CTH gene DNA methylation heat shock response microglia drug target discovery amyloid-? oligomer therapy CR1 length polymorphism methylome APOE gene ubiquitin magnetic resonance imaging (MRI) neuronal degeneration type 2 diabetes Pin1 mild cognitive impairment dairy products endoplasmic reticulum oxidative stress Hispanics CDK5R1 |
| ISBN |
9783039214082
303921408X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367750403321 |
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Macreadie Ian
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Products and Neuroprotection
| Natural Products and Neuroprotection |
| Autore | Angeloni Cristina |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (338 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
5-(3,5-dihydroxyphenyl)-γ-valerolactone
algae Alzheimer's disease animal studies antioxidant ascaroside pheromone auraptene autophagy B-cell lymphoma 2 beneficence bioactive compound bioavailability blood-brain barrier C. elegans calcium catechin cell death Centella asiatica chaperones Chionanthus retusus clinical trial cognition cognitive dysfunction curcumin cyclic AMP dauer depression dopamine neuron dynamics epigallocatechin gallate ethics flavonoid flower free radicals glycogen synthase kinase 3 green tea heme oxygenase hippocampus HO-1 hormesis human studies in vitro studies inflammation learning Lippia citriodora medical liability memory microbiota mitochondria mitochondrial dysfunction mitophagy Multiple Sclerosis n/a natural compound natural compounds natural extract natural products neurodegeneration neurodegenerative disease neurodegenerative diseases neuroinflammation neuronal signaling neuroprotection NO nonmaleficence nutraceuticals oxidative injury oxidative stress Parkinson's disease Parkinson's disease (PD) patients' autonomy protein aggregation protein poshophatase 2 proteostasis relaxation safety profile seaweeds sexual behavior stress response survival signals symptom synapse loss tau protein terpenes, rotenone thymol type 2 diabetes ubiquitin-proteasome ubiquitin‒proteasome system (UPS) unfolded protein response vascular damage VEE Vitamin D Vs β-amyloid peptide |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557705603321 |
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Angeloni Cristina
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Neurotoxicity of Environmental Metal Toxicants
| Neurotoxicity of Environmental Metal Toxicants |
| Autore | Ortega Richard |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (190 p.) |
| Soggetto topico | Medical toxicology |
| Soggetto non controllato |
Alzheimer's disease
Alzheimer's disease (AD) animal fluency apoptosis arsenic cadmium cassava CERAD cholesterol cobalt cognitive function copper diet DSST environmental exposure environmental risk factor ethnicity grasspea grip strength heavy metals high fat lead low fat manganese manganese speciation mercury metal metal-on-metal (MoM) hip implants metals methylmercury mitochondrial dysfunction morels n/a neurodegeneration neurological disorders neuromotor system neurotoxicity NHANES phytochemicals protein metabolism proteostasis race RNA-Seq RT-qPCR SH-SY5Y soil and water pollution synapse systemic cobaltism |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595072503321 |
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Ortega Richard
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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State-of-Art in Innate Immunity
| State-of-Art in Innate Immunity |
| Autore | Fischer Silvia |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (188 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
AIM2
albumin angiogenesis apoptosis ASC autoinflammation bacteria cancer caspase caspase-1 caspase-3 caspase-7 caspase-8 cell culture chronic liver diseases COVID-19 crosstalk cytokines cytomegalovirus DAMP Drosophila suzukii endothelial cells endothelin receptor extracellular RNA extracellular traps gamma delta T cells hemocytes hepatic non-parenchymal cells HMGB1 infection inflammasome inflammation inflammatory cell death innate immunity interleukin-1β IRF1 ischemia macrophage polarization macrophages MLKL n/a necroptosis NETs neutrophil extracellular traps neutrophils NLR NLRP3 nociceptor PANoptosis PANoptosome plasmatocytes plasticity proliferation proteasomopathies proteinopathies proteostasis Pyrin pyroptosis RAGE redundancy repurposing ribosomopathies RIPK1 RIPK3 SIRT1 SMOC1 thrombin TLR4 toll-like receptors type I interferons ZBP1 α7-nicotinic acetylcholine receptor γδ T cells |
| ISBN | 3-0365-5324-X |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910619465003321 |
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Fischer Silvia
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| MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Amazing World of IDPs in Human Diseases
| The Amazing World of IDPs in Human Diseases |
| Autore | Monti Simona Maria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (196 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
actin
alpha-synuclein cancer circular dichroism cytoskeleton remodeling de novo EPR spectroscopy evolutionary origin flexibility fluorescence gene duplications human disease importin interface core and rim intrinsically disordered protein intrinsically disordered protein (IDP) intrinsically disordered proteins intrinsically disordered regions isothermal titration calorimetry isothermal titration calorimetry (ITC) linear motifs Methyl-CpG-binding protein 2 (MeCP2) molecular docking molecular recognition features n/a NADH-26S proteasome neurodegenerative diseases NMR nuclear magnetic resonance (NMR) nuclear protein 1 (NPR1) peptide pre-structured motifs (PreSMos) proline-rich motif protein degradation protein misfolding protein stability protein structural dynamics protein-DNA interaction protein-ligand interaction protein-protein interactions proteostasis Rett syndrome secondary structure propensity SH3 domain single nucleotide variants site-directed spin labeling ubiquitin independent degradation ubiquitin-proteasome system WASp interacting protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557334303321 |
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Monti Simona Maria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The HSP70 Molecular Chaperone Machines
| The HSP70 Molecular Chaperone Machines |
| Autore | Matthias P. Mayer |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 online resource (69 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
Disaggregase
Heat-Shock Proteins Misfolding diseases proteostasis unfoldase |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910220042603321 |
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Matthias P. Mayer
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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