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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (606 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
1,2,3-triazole
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 3,6-dibromocarbazole 4-(pyridin-4-yloxy)benzamide 5-bromoindole 5-fluorouracil ABCB1 (P-glycoprotein) actin ADME allene amides/esters androgen receptor anti-cancer activity anti-neuroinflammation anti-ovarian cancer anti-tumor anticancer anticancer activity anticancer agent anticancer agents anticancer compounds antimitotic agents antioxidant activity antiproliferative activity antiproliferative agent antitumor antitumor activity apalutamide apoptosis aromatase benzimidazole benzofuran-pyrazole benzofurans beta-lapachone bivalency breast cancer c-Met carbazole cell cycle chemical synthesis chemoresistance chrysin analogues colchiceine colchicine amide colchicine analogs colchicine sulfonamide colon cancer computational docking coumarin crystal structure cyanopyridone cytotoxic activity cytotoxic properties cytotoxicity darolutamide DFT study dihydroartemisinin dihydropyranoindole docking docking studies drug discovery drug resistance E-stereoselective enzalutamide enzyme inhibition estrone derivatives flavonoid flavonoids gemcitabine HDAC inhibitors HeLa HepG2 hydrates hydrazine IGF-1R IL-12 immune modulation indoleamine 2,3-dioxygenase inflammation inhibitor K562 kinase inhibitor MCF-7 MDM2-p53 interaction migration mimetics molecular simulation MOLT-4 multidrug resistance (MDR) reversal N-substituted pyrazoline nanoparticles natural product neuroblastoma NIH3T3 o-nitro-benzyl organosilicon compounds ortho-quinones ovarian cancer overcoming drug resistance P-glycoprotein P-MAPA PARP inhibitor PARP-1 inhibition phenylpyrazolopyrimidine photoactivatable protecting groups PI3Ks PI3Kα inhibitor PI3Kδ inhibitors polyvalency prodrug prostate cancer PROTACs protein degradation protein kinase protein-protein interactions Pyrazole pyrazolopyridine pyridotriazine quinazolin-4(3H)-one quinazolin-4(3H)-thione regioselective salinomycin Schiff base SILA-409 (Alis-409) SILA-421 (Alis-421) Src substituted pyridine synergy synthesis Talazoparib tanshione IIA taxoids thiazolidinone Thienopyrimidine thienopyrimidinone thiocolchicine thiopene thioxotriazopyridine TLR signaling topoisomerase II inhibitor triazolothiadiazine triple-negative breast cancer tryptophan metabolism tubulin inhibitors tumor specificity urea virtual screening xanthones yeast-based assays zampanolide βIII-tubulin |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Anticancer Inhibitors
| Anticancer Inhibitors |
| Autore | Fantacuzzi Marialuigia |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (216 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
breast cancer
tamoxifen LY294002 synergism apoptosis cell cycle tea (Camellia sinensis) flowers BTFS A2780/CP70 ovarian cancer cells S phase cell cycle arrest nicotinamide phosphoribosyltransferase NAD+ biosynthesis inhibitor azacyclohexane anticancer drug drug design enthalpy effect NSCLC Cathepsin K cell proliferation cell migration cell invasion mTOR isatin-hydrazones cytotoxicity CDK2 inhibitor ATP competitive inhibitor ADME analysis receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity agonistic activity saponins phytochemicals tea (Camellia sinensis) flower ovarian cancer autophagy ZMYND8 tumorigenesis epigenetic regulation pro-oncogenic effects tumor suppression tacrine-coumarin derivatives DNA topoisomerases I, II lung carcinoma cells A549 chemotherapy prodrug drug targeting overexpressed enzymes ADC ADEPT GDEPT LEAPT PROTAC cyclin-dependent kinase cancer resistance small molecule inhibitors PROTACs statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin fluvastatin atorvastatin pravastatin HMG-CoA reductase inhibitors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069203321 |
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Fantacuzzi Marialuigia
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Celebrating Applied Sciences Reaches 20,000 Articles Milestone : Feature Papers in Applied Biosciences and Bioengineering Section
| Celebrating Applied Sciences Reaches 20,000 Articles Milestone : Feature Papers in Applied Biosciences and Bioengineering Section |
| Autore | Cappello Francesco |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (228 p.) |
| Soggetto topico |
Biotechnology
Technology: general issues |
| Soggetto non controllato |
ABTS•+ antioxidant capacity
accuracy acute lymphoblastic leukaemia adhesion albumin extravasation anthocyanins' stability anti-epileptic drugs antioxidant activity asthma balance disability berries biomarkers biothiols blood plasma chaperone system chronic obstructive pulmonary disease CNS colorimetric probes COPD critically ill patients depression drug delivery drug targets elderberry endothelial glycocalyx epilepsy epithelial-mesenchymal trophic unit exosomes extracellular vesicles fluid loading fluoropolymers food-borne gamma-delta T cells gastric carcinogenesis gastric dysplasia gastritis Gibbs homology gold nanoparticles halloysite halophyte heart disease risk factors Hsp60 inflammation inflammatory response intensive care unit intestinal metaplasia ISO 16140:2016 juice concentrate kit LAMP levetiracetam liquid biopsy metastasis microbiota microstamp minerals muco-microbiotic layer n/a nanoclay nanovesicles novel ingredient oils organoid outer membrane vesicles periodontitis phenolic compounds polymeric color population pharmacokinetic modeling post-operative protein-protein interactions regenerative medicine Salmonella Sambucus nigra L. sea purslane sensitivity serum HSP90 simulated dosage schemes specificity spheroid storage effect stroke surgery systems biology tissue engineering tumor progression validation van der Waals force volatile wound healing yoga |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Celebrating Applied Sciences Reaches 20,000 Articles Milestone |
| Record Nr. | UNINA-9910580215703321 |
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Cappello Francesco
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Disease and the Hippo Pathway: Cellular and Molecular Mechanisms
| Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| Autore | Hansen Carsten Gram |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (226 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
adaptive immunity
angiogenesis anti-cancer therapy autoimmunity cancer cancer immunity castration resistance chromatin ECM EMT epigenetic feedback loops fibroblasts fibrosis G protein-coupled receptor GPCR Hippo hippo pathway Hippo pathway Hippo signalling innate immunity LATS LATS (large tumor suppressor kinase) LATS1/2 Lats2 Mps one binder MST MST (mammalian STE20-like protein kinase) MST1/2 myofibroblast n/a NDR peripheral nerve sheath tumor phosphorylation prostate cancer protein kinase protein-protein interactions schwannoma signal cross-talk signal transduction skin cancer skin development stem cell stem cells STK38 STRIPAK structure biology Taz TAZ TAZ (transcriptional co-activator with PDZ-binding motif) TEAD transcription tumorigenesis vascular mimicry wound healing Yap YAP YAP (yes-associated protein) YAP/TAZ zebrafish |
| ISBN | 3-03921-777-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Disease and the Hippo Pathway |
| Record Nr. | UNINA-9910367742003321 |
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Hansen Carsten Gram
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Malignant Mesothelioma
| Malignant Mesothelioma |
| Autore | L. Pouliquen Daniel |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (328 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
asbestos
asbestos exposure BAP1 biomarkers cancer biomarkers cancer-specific mutations cancers carbon nanotubes carcinogenesis CDKN2A circulating tumor DNA dendritic cells DNA damage response DNA methylation DNA sequencing drug repurposing epigenome-wide analysis epithelioid extrapleural pneumonectomy fatty acid-binding protein FDG first line gene expression genomics Hippo pathway histotype immune therapy immunogenicity immunohistochemistry immunotherapy infiltrating immune cells inflammation interaction analysis laminin subunit beta-2 liquid biopsies lurbinectedin lymphocyte-to-monocyte ratio macrophage-capping protein malignant mesothelioma malignant pleural mesothelioma mesothelioma mesothelium meta-analysis metabolomics MPM MTAP mutation n/a network analysis NF2 oxidative stress PET-CT plasma pleural effusion pleural mesothelioma pleurectomy decortication predictive biomarker prognostic biomarker protein-protein interactions proteomics PTCH1 radiotherapy redox-sensitive factors sarcomatoid selenium-binding protein 1 SETD2 survival survival analysis systematic review systems biology targeted therapy therapy response tumor microenvironment tumor suppressor tumor-associated macrophages VATS WDPM well-differentiated papillary mesothelioma |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557359303321 |
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L. Pouliquen Daniel
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mechanisms of ER Protein Import
| Mechanisms of ER Protein Import |
| Autore | Zimmermann Richard |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (258 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
bimolecular luminescence complementation
chaperones co-translational translocation competition contact sites cyclotriazadisulfonamide differential protein abundance analysis DNAJC3 EMC endoplasmic reticulum ER protein translocase ER quality control ER translocon ER-SURF fidelity folding GET high throughput screening hydrophobicity inhibitor insertion label-free quantitative mass spectrometry lipid droplets membrane extraction membrane insertion membrane protein membrane protein insertion membrane proteins mitochondria molecular docking molecular dynamics simulations molecular modelling n/a NAC nascent peptide chain nascent polypeptide-associated complex peroxisomes PEX3 positive-inside rule preprotein protein targeting protein translocation protein transport protein-protein interactions ribosome ribosome stalling Sec61 Sec61 complex Sec61 dependent translocation Sec61 translocase Sec61 translocon Sec62 Sec63 signal peptidase signal peptide signal recognition particle signal recognition particle dependent protein targeting signal sequence SND split luciferase SRP synthetic peptide complementation translocon transmembrane helix transmembrane segment TRAP complex Zellweger syndrome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910576886203321 |
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Zimmermann Richard
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Natural Language Processing: Emerging Neural Approaches and Applications
| Natural Language Processing: Emerging Neural Approaches and Applications |
| Autore | Esposito Massimo |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (544 p.) |
| Soggetto topico |
Computer science
Information technology industries |
| Soggetto non controllato |
adversarial attack
adversarial example antonymy detection attention mechanism attention model BERT BERT word embedding bidirectional long short-term memory (bidirectional LSTM) bidirectional LSTM CRF bidirectional RNN bilingual translation BM25 Cantonese causal encoder chief complaint classification clinical named entity recognition cloze test CNN dictionary commonsense conditional random field CoNLL context-to-entity attention contextual features conversation knowledge convolutional neural networks convolutional neural networks (CNN) cross-lingual classification deep learning deep learning (DL) deep learning NER deep neural networks delayed combination dialogue context encoding dialogue management disease diagnosis Doc2vec dual pointer network encoder-decoder neural network encodings entity recognition error assessment error probability FAQ classification fixing ontologies information extraction knowledge base Korean dataset Korean syntax language modeling LaTeX decompilation logic error long short-term memory long short-term memory network LSTM machine comprehension medical specialist multi-agent reinforcement learning multi-level word embeddings multi-turn chatbot multilingual multilingual transformers multitask model n/a named entity recognition natural language processing Natural Language Processing (NLP) neural architecture search neural language model neural network neural networks news analysis NLP online social networks ontologies OntoNotes open information extraction paraphrase identification partial match polarity primary healthcare programming education protein-protein interactions quality metrics question classification quick fix R-GCNs recurrent neural networks reinforce learning relation extraction reward shaping rule-based rumor detection sememe prediction sememes sentence completion sentence retrieval sentiment analysis sentiment classification sequence similarity speech-to-text spoken natural language structural information text classification text mining text normalization text summary TF−ISF tourism big data toxic comments transfer learning user simulation virtual medical assistant WGAN-based response generation word embedding word embeddings word ordering word representation learning word to vector word2vec XGA model zero-shot learning |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Natural Language Processing |
| Record Nr. | UNINA-9910566478103321 |
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Esposito Massimo
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions
| Plant Responses and Tolerance to Salt Stress: Physiological and Molecular Interventions |
| Autore | Hasanuzzaman Mirza |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (364 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
14-3-3 gene family
ABA abiotic elicitors abiotic stress amino acids antioxidant defense antioxidants apoplast association analysis betaine aldehyde dehydrogenase 1 (BADH1) bioinformatics analysis bolTLP1 broccoli C2H2 zinc finger protein C3-CAM intermediate calcineurin B-like proteins calcium candidate genes carbohydrates carotenoids cell wall regulation chlorophyll fluorescence climate change common ice plant CPA gene family cultivated rice differentially expressed genes domestication drought stress functional screening halophyte species heterologous expression Hordeum vulgare Hordeum vulgare L. hormone mediation HT tolerance hydrogen peroxide hydroxyindole-O-methyltransferase gene ion homeostasis ion transport lemon balm lipid peroxidation Malus domestica marker-assisted selection (MAS) medicinal plants melatonin Mesembryanthemum crystallinum microtubules Millettia pinnata mulberry n/a Na+ accumulation NADPH oxidases NOX osmoprotectants osmotic homeostasis osmotic stress over-expression oxidative stress phenolic metabolites phenylpropanoid metabolism phytohormones Populus simonii × P. nigra protein-protein interactions proteomics PsnNAC036 quantitative trait locus (QTL) radish respiratory burst oxidase homolog RBOH gene expression rice (Oryza sativa L.) RNA-seq analysis ROS ROS-scavengers RsNHX1 saline adaptations salinity salt adaptation salt resistance salt stress salt tolerance secondary metabolites seedling stress signaling thaumatin-like proteins (TLPs) TMT proteomics tolerance transcription factor Triticum aestivum L. tubulin virus-induced gene silence wild rice xanthophyll cycle α-/γ-tocopherols |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Plant Responses and Tolerance to Salt Stress |
| Record Nr. | UNINA-9910576886303321 |
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Hasanuzzaman Mirza
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Recent Trends in Computational Research on Diseases
| Recent Trends in Computational Research on Diseases |
| Autore | Altaf-Ul-Amin Md |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (130 p.) |
| Soggetto topico |
History of engineering & technology
Technology: general issues |
| Soggetto non controllato |
adenosine methylation
association test atrial fibrillation automated curation bathing blood pressure cardiac fibrosis chronic diseases compound-protein interaction copy number variants cuffless measurement data augmentation data mining deep learning disease-related traits drug discovery drug repurposing drug-target interactions ECG ECG quality assessment genetic variation heart failure heart rate variability herbal medicine hypertrophic cardiomyopathy Jamu left ventricular outflow tract obstruction longitudinal experiment m6A machine learning maximum flow molecular mechanisms myocardial ischemia n/a neuronal development nonlinear regression plethysmograph protein-protein interactions quantitative analysis RNA modification sequential order sudden cardiac death t-test water temperature |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566465403321 |
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Altaf-Ul-Amin Md
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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The Amazing World of IDPs in Human Diseases
| The Amazing World of IDPs in Human Diseases |
| Autore | Monti Simona Maria |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (196 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
actin
alpha-synuclein cancer circular dichroism cytoskeleton remodeling de novo EPR spectroscopy evolutionary origin flexibility fluorescence gene duplications human disease importin interface core and rim intrinsically disordered protein intrinsically disordered protein (IDP) intrinsically disordered proteins intrinsically disordered regions isothermal titration calorimetry isothermal titration calorimetry (ITC) linear motifs Methyl-CpG-binding protein 2 (MeCP2) molecular docking molecular recognition features n/a NADH-26S proteasome neurodegenerative diseases NMR nuclear magnetic resonance (NMR) nuclear protein 1 (NPR1) peptide pre-structured motifs (PreSMos) proline-rich motif protein degradation protein misfolding protein stability protein structural dynamics protein-DNA interaction protein-ligand interaction protein-protein interactions proteostasis Rett syndrome secondary structure propensity SH3 domain single nucleotide variants site-directed spin labeling ubiquitin independent degradation ubiquitin-proteasome system WASp interacting protein |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557334303321 |
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Monti Simona Maria
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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