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Anticancer Agents : Design, Synthesis and Evaluation
| Anticancer Agents : Design, Synthesis and Evaluation |
| Autore | Chen Qiao-Hong |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (606 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
1,2,3-triazole
2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 3,6-dibromocarbazole 4-(pyridin-4-yloxy)benzamide 5-bromoindole 5-fluorouracil ABCB1 (P-glycoprotein) actin ADME allene amides/esters androgen receptor anti-cancer activity anti-neuroinflammation anti-ovarian cancer anti-tumor anticancer anticancer activity anticancer agent anticancer agents anticancer compounds antimitotic agents antioxidant activity antiproliferative activity antiproliferative agent antitumor antitumor activity apalutamide apoptosis aromatase benzimidazole benzofuran-pyrazole benzofurans beta-lapachone bivalency breast cancer c-Met carbazole cell cycle chemical synthesis chemoresistance chrysin analogues colchiceine colchicine amide colchicine analogs colchicine sulfonamide colon cancer computational docking coumarin crystal structure cyanopyridone cytotoxic activity cytotoxic properties cytotoxicity darolutamide DFT study dihydroartemisinin dihydropyranoindole docking docking studies drug discovery drug resistance E-stereoselective enzalutamide enzyme inhibition estrone derivatives flavonoid flavonoids gemcitabine HDAC inhibitors HeLa HepG2 hydrates hydrazine IGF-1R IL-12 immune modulation indoleamine 2,3-dioxygenase inflammation inhibitor K562 kinase inhibitor MCF-7 MDM2-p53 interaction migration mimetics molecular simulation MOLT-4 multidrug resistance (MDR) reversal N-substituted pyrazoline nanoparticles natural product neuroblastoma NIH3T3 o-nitro-benzyl organosilicon compounds ortho-quinones ovarian cancer overcoming drug resistance P-glycoprotein P-MAPA PARP inhibitor PARP-1 inhibition phenylpyrazolopyrimidine photoactivatable protecting groups PI3Ks PI3Kα inhibitor PI3Kδ inhibitors polyvalency prodrug prostate cancer PROTACs protein degradation protein kinase protein-protein interactions Pyrazole pyrazolopyridine pyridotriazine quinazolin-4(3H)-one quinazolin-4(3H)-thione regioselective salinomycin Schiff base SILA-409 (Alis-409) SILA-421 (Alis-421) Src substituted pyridine synergy synthesis Talazoparib tanshione IIA taxoids thiazolidinone Thienopyrimidine thienopyrimidinone thiocolchicine thiopene thioxotriazopyridine TLR signaling topoisomerase II inhibitor triazolothiadiazine triple-negative breast cancer tryptophan metabolism tubulin inhibitors tumor specificity urea virtual screening xanthones yeast-based assays zampanolide βIII-tubulin |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Anticancer Agents |
| Record Nr. | UNINA-9910557129103321 |
Chen Qiao-Hong
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Disease and the Hippo Pathway: Cellular and Molecular Mechanisms
| Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| Autore | Hansen Carsten Gram |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (226 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
adaptive immunity
angiogenesis anti-cancer therapy autoimmunity cancer cancer immunity castration resistance chromatin ECM EMT epigenetic feedback loops fibroblasts fibrosis G protein-coupled receptor GPCR Hippo hippo pathway Hippo pathway Hippo signalling innate immunity LATS LATS (large tumor suppressor kinase) LATS1/2 Lats2 Mps one binder MST MST (mammalian STE20-like protein kinase) MST1/2 myofibroblast n/a NDR peripheral nerve sheath tumor phosphorylation prostate cancer protein kinase protein-protein interactions schwannoma signal cross-talk signal transduction skin cancer skin development stem cell stem cells STK38 STRIPAK structure biology Taz TAZ TAZ (transcriptional co-activator with PDZ-binding motif) TEAD transcription tumorigenesis vascular mimicry wound healing Yap YAP YAP (yes-associated protein) YAP/TAZ zebrafish |
| ISBN | 3-03921-777-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Disease and the Hippo Pathway |
| Record Nr. | UNINA-9910367742003321 |
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Hansen Carsten Gram
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Research of Endometrial Pathophysiology / Paola Viganò, Andrea Romano
| Molecular Research of Endometrial Pathophysiology / Paola Viganò, Andrea Romano |
| Autore | Viganò Paola |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (378 p.) |
| Soggetto non controllato |
endometrial stromal cells
endometrial cell uterine cancer regeneration stem cell markers RANK chronic endometritis small RNA sequencing HOXA10 Vitamin D PPP2R1A molecular marker translational research angiogenesis endometriosis oestradiol mtDNA mutations antioxidant response protein phosphatase SMAP circulating tumour cells (CTCs) circulating tumour DNA (ctDNA) estrogen dependent endometrial regeneration mesenchymal stem cells endometrial cancer niche gene expression phosphoinositide 3-kinase lncRNAs mitochondrial biogenesis inflammation preclinical studies miRNA orthoxenograft tight junction proliferation aromatase testosterone CRISPR/Cas9 endometrium developmental pathway PP2A avatar infertility prognosis gene editing kinase inhibitor implantation haploinsufficiency contrast-enhanced CT scan pathway dehydroepiandrosterone (DHEA) CTCF PIK3CB zinc finger ectopic stroma liquid biopsy type II endometrial carcinoma eutopic and ectopic endometrium preclinical models EDN1 uterine aspirate cell contacts tumour suppressor gene pathogenomics mitochondrial dynamics adult stem cells PIK3CA murine models menstrual cycle immunomodulation decidualisation breakdown bioluminescence imaging protein kinase macrophages adherens junction exosomes immunohistochemistry orthotopic xenograft model decidualization p110? deficit of complex I targeted therapy mesenchymal stem cell sulfatase TRP channels personalized medicine mitophagy miR-375 migration microRNA gap junction cancer LGR5 miR-139-5p |
| ISBN |
9783039214969
3039214969 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367752903321 |
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Viganò Paola
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Plant Natural Products for Human Health
| Plant Natural Products for Human Health |
| Autore | Zhang Hongjie |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (514 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
A?
A549 cells acetaminophen acute liver injury AD adjuvant adjuvant-induced arthritis Amadori rearrangement compounds AMPK animals anti-inflammation anti-malaria activity antifungal activity antioxidant enzymes antiproliferation antistaphylococcal activity antitubercular activity APAP apoptosis arthritis aspirin Astragali Radix astragaloside IV automation bergamot bergapten biofilm bioinformatics biological activity bitter orange bleeding time BMP/Smad calorie restriction cannabigerol cannabinoid type 1 receptor Cannabis sativa caspases catechin celastrol cinnamamides computational softwares copaiba curcumin cytoxicity dendritic cells dietary supplements differentiation dihydromyricetin diterpenoids drug design and development drug discovery EGCG endoplasmic reticulum stress essential oil ethnopharmacology flavonoid flavonoids fucoidan garlic genistein ginseng global health glucans gluconeogenesis Glycyrrhiza uralensis gomisin N grapefruit green tea heart heat-process heme oxygenase HepaRG cells hepatic steatosis hepatotoxicity herb-drug interactions hinokitiol hpatoprotection human health human-hair-follicle dermal papilla cells hyperglycemia immune modulation immunomodulator inflammation inflammatory bowel disease innovation insulin resistance iridoids ischemia Keap1 kumquat lemon lime lipogenesis liposomes lychee seed mandarin medicinal plants melanoma cell microbiome migration mitochondrial bioenergetics mitogen-activated protein kinase MMPs molecular targets morin hydrate mouse-hair growth MTT assay myocardial hypertrophy NAFLD nanoparticles natural products neroli neuroinflammation Neuroprotective Nrf2 nuclear factor-kappaB OH· free radical oleoresin omics onion orange petitgrain oxidative stress oxygen consumption rate P. eryngii p53/Bax Panax notoginseng saponins paracetamol PC12 cells Penthorum chinense Pursh PET inhibition pharmacokinetic study PhGs phytocannabinoid phytochemicals plant natural product plants Plasmodium parasites platelet activation precision medicine preclinical studies prenylated flavonoids procyanidin A2 protein kinase reperfusion resveratrol rheumatoid arthritis scoulerine sesquiterpenoids Shh/Gli SIRT1 sirtuin 3 small molecules structure-activity relationship sweet orange targeted delivery TGF-? thromboembolism time-kill assay toxicity traditional medicine Tripterygium wilfordii triptolide triterpenic acids WNT/?-catenin yuzu Ziziphus jujuba |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346688103321 |
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Zhang Hongjie
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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