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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (452 p.) |
| Soggetto non controllato |
HDACs
transcription epigenetics spermatozoa par complex A769662 MDCK skeletal muscle AID phosphorylation energy metabolism monocytes autophagy CML liver hindlimb suspension pregnancy preeclampsia gestational diabetes mellitus CaMKK2 assisted reproduction techniques nutrient-sensing signals sonic hedgehog protein acetylation glycogen storage disease AMPK adenosine monophosphate-activated protein kinase AICAR indirect calorimetry IL-1? MyHC I(?) HDAC4/5 endothelial cells infection hepatocyte p70S6K lipid metabolism host defense exercise kidney disease heat shock protein ?RIM mycobacteria activation loop developmental origins of health and disease (DOHaD) CREB TAK1 metabolic-inflammation phenylephrine AMP-activated protein kinase (AMPK) KATs 2-methoxyestradiol DNA methylation NLRP3 pump ?-linker steatosis AMPK kinase stress endothelial nitric-oxide synthase vasodilation adherent junctions epithelial cells glycogen Akt synaptic activation cellular energy sensing glucose uptake transporter co-expression atrophy nutrigenomics motility vasoconstriction fatty acid oxidation oxidative stress AS160 membrane histone modification sirtuin 1 (SIRT1) chromatin remodeling insulin signalling dietary fatty acids ULK CMML adaptive thermogenesis mTOR MDS mechanical unloading AML endothelial function medulloblastoma PKA adipose tissue NAD+ membranes nutrition ZO-1 TBC1D4 adipocyte soluble Adenylyl cyclase metabolism renin-angiotensin system energy utilization proteasome differentiation signaling peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) hypertrophy AMP-activated protein kinase metabolic disease LKB1 soleus muscle macrophages Immediate early genes CBS benign motor endplate remodeling ionomycin nectin-afadin tight junctions resveratrol protein kinase B regrowth mitochondria protein synthesis energy deficiency catechol-O-methyltransferase fiber-type microarrays carrier acetyl-CoA hypertension 3T3-L1 hypothalamus food intake |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (387 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
3D-QSAR
pharmacophore modeling ligand-based model HDACs isoform-selective histone deacetylase inhibitors aminophenylbenzamide hERG toxicity drug discovery fingerprints machine learning deep learning gene expression signature drug repositioning approaches RNA expression regulation high-throughput virtual screening dual-target lead discovery neurodegenerative disorders Alzheimer's disease dual mode of action multi-modal nicotinic acetylcholine receptor acetylcholinesterase molecular docking methotrexate drug resistance human dihydrofolate reductase virtual screening molecular dynamics simulation epitope binning epitope mapping epitope prediction antibody:antigen interactions protein docking glycoprotein D (gD) herpes simplex virus fusion proteins Src inhibitors pharmacophore model molecular dynamics simulations in silico COX-2 inhibitors molecular modeling sodium-glucose co-transporters 2 FimH uropathogenic bacteria urinary tract infections diabetes drug-resistance mutations HIV-2 protease structural characterization induced structural deformations SARS-CoV-2 COVID-19 multiprotein inhibiting natural compounds MD simulation 3CL-Pro antivirals docking simulations drug repurposing consensus models binding space isomeric space MRP4 SNPs variants protein threading modeling molecular dynamics binding site hTSPO PK11195 cholesterol homology modeling molecular dynamics (MD) simulation carbon nanotubes Stone-Wales defects haeckelite defects doxorubicin encapsulation drug delivery system binding free energies noncovalent interactions main protease mutants inhibitors PF-00835231 Mycobacterium tuberculosis tuberculosis proteasome natural compounds multiscale multitargeting polypharmacology computational biology drug repositioning structural bioinformatics proteomic signature skin aging oxidative stress aging progression mechanism genome-wide genetic and epigenetic network (GWGEN) systems medicine design multiple-molecule drug immunoproteasome non-covalent inhibitors MD binding metadynamics induced-fit docking |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
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Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein Quality Controlling Systems in Plant Responses to Environmental Stresses
| Protein Quality Controlling Systems in Plant Responses to Environmental Stresses |
| Autore | Yule Liu |
| Pubbl/distr/stampa | Frontiers Media SA, 2018 |
| Descrizione fisica | 1 electronic resource (214 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
unfolded protein response
proteasome environmental stress autophagy plant heat shock proteins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346745403321 |
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Yule Liu
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| Frontiers Media SA, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges
| Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges |
| Autore | Feist Eugen |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (266 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
gout
febuxostat colchicine hepatotoxicity prophylaxis myositis inflammatory idiopathic myopathy dysphagia aspiration pneumonia immunoglobulin G4-related orbital disease (IgG4-ROD) orbital lymphoma (OL) computed tomography (CT) Hounsfield unit imaging autoinflammation arthritis CAPS FCAS MWS CINCA NOMID hearing loss urticarial-like rash autoinflammatory disease anti-IL-1 treatment rheumatoid arthritis synovitis neoplasms edema inflammation new genetic variant monogenic autoinflammatory syndrome diagnostic delay anakinra damage index genetic inheritance personalized therapy Interleukin-1 autoinflammatory diseases FMF coronavirus SARS-CoV-2 antibody response adult-onset Still's disease autoinflammatory disorder systemic-onset juvenile idiopathic arthritis haemophagocytic lymphohistiocytosis macrophage activation syndrome IFN-γ JAK inhibitor proliferation DNA damage repair γH2AX PBMCs T lymphocytes proteasome autoimmune proteasome-associated autoinflammatory syndrome therapy IL-1 inhibitors NGS SURF spondyloarthritis human leukocyte antigen undifferentiated enthesitis and/or arthritis ASAS classification criteria clinical management canakinumab cytokines |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557349503321 |
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Feist Eugen
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and Autophagy
| Ubiquitin and Autophagy |
| Autore | Nazarko Taras Y |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (294 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
PSMD14
ubiquitin retrograde trafficking APP autophagy Cx43 GABARAP gap junction MAPLC3 leukodystrophies globoid cell leukodystrophy psychosine p62 proteasome toll-like receptor 4 TRAF6 BECN1 ATG12~5/16 complex Dictyostelium ubiquitin-like protein phagocytosis pinocytosis UPS ubiquitin-proteasome system crosstalk tissue specificity C. elegans NFAT5 autophagy initiation islet FIP200 unfolded protein response UPR Atg8 LC3 LIR motif SAR UBL neurodegenerative diseases autophagy-lysosome pathway lysosome selective autophagy ubiquitination degradation the ubiquitin-proteasome system plants mitophagy aggrephagy lysophagy xenophagy lipophagy nucleophagy ER-phagy cargo receptors sorting nexins retromer endosome |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339503321 |
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Nazarko Taras Y
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System
| Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| Autore | Ashok N. Hegde |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 electronic resource (241 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
proteasome
memory neuroinflammation neurodegenerative synaptic plasticity aging deubiquitinating Huntington's disease Alzheimer's disease glutamate receptors |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Ubiquitin and the Brain |
| Record Nr. | UNINA-9910261140803321 |
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Ashok N. Hegde
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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