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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (452 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
?-linker
?RIM 2-methoxyestradiol 3T3-L1 A769662 acetyl-CoA activation loop adaptive thermogenesis adenosine monophosphate-activated protein kinase adherent junctions adipocyte adipose tissue AICAR AID Akt AML AMP-activated protein kinase AMP-activated protein kinase (AMPK) AMPK AMPK kinase AS160 assisted reproduction techniques atrophy autophagy beiging CaMKK2 carrier catechol-O-methyltransferase CBS cellular energy sensing chromatin remodeling CML CMML co-expression CREB developmental origins of health and disease (DOHaD) dietary fatty acids differentiation DNA methylation endothelial cells endothelial function endothelial nitric-oxide synthase energy deficiency energy metabolism energy utilization epigenetics epithelial cells exercise fatty acid oxidation fiber-type food intake gestational diabetes mellitus glucose uptake glycogen glycogen storage disease HDAC4/5 HDACs heat shock protein hepatocyte hindlimb suspension histone modification host defense hypertension hypertrophy hypothalamus IL-1? Immediate early genes indirect calorimetry infection insulin signalling ionomycin KATs kidney disease lipid metabolism liver LKB1 macrophages MDCK MDS mechanical unloading medulloblastoma membrane membranes metabolic disease metabolic-inflammation metabolism microarrays mitochondria monocytes motility motor endplate remodeling mTOR mycobacteria MyHC I(?) n/a NAD+ nectin-afadin NLRP3 nutrient-sensing signals nutrigenomics nutrition oxidative stress p70S6K par complex peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) phenylephrine phosphorylation PKA preeclampsia pregnancy proteasome protein acetylation protein kinase B protein synthesis pump regrowth renin-angiotensin system resveratrol signaling sirtuin 1 (SIRT1) skeletal muscle soleus muscle soluble Adenylyl cyclase sonic hedgehog spermatozoa steatosis stress synaptic activation TAK1 TBC1D4 tight junctions transcription transporter ULK vasoconstriction vasodilation ZO-1 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics
| Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics |
| Autore | Tutone Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (387 p.) |
| Soggetto topico |
Chemistry
Research & information: general |
| Soggetto non controllato |
3CL-Pro
3D-QSAR acetylcholinesterase aging progression mechanism Alzheimer's disease aminophenylbenzamide antibody:antigen interactions antivirals binding free energies binding site binding space carbon nanotubes cholesterol computational biology consensus models COVID-19 COX-2 inhibitors deep learning diabetes docking simulations doxorubicin encapsulation drug delivery system drug discovery drug repositioning drug repositioning approaches drug repurposing drug resistance drug-resistance mutations dual mode of action dual-target lead discovery epitope binning epitope mapping epitope prediction FimH fingerprints gene expression signature genome-wide genetic and epigenetic network (GWGEN) glycoprotein D (gD) haeckelite defects HDACs hERG toxicity herpes simplex virus fusion proteins high-throughput virtual screening HIV-2 protease homology modeling hTSPO human dihydrofolate reductase immunoproteasome in silico induced structural deformations induced-fit docking inhibitors isoform-selective histone deacetylase inhibitors isomeric space ligand-based model machine learning main protease MD binding MD simulation metadynamics methotrexate molecular docking molecular dynamics molecular dynamics (MD) simulation molecular dynamics simulation molecular dynamics simulations molecular modeling MRP4 multi-modal multiple-molecule drug multiprotein inhibiting natural compounds multiscale multitargeting mutants Mycobacterium tuberculosis n/a natural compounds neurodegenerative disorders nicotinic acetylcholine receptor non-covalent inhibitors noncovalent interactions oxidative stress PF-00835231 pharmacophore model pharmacophore modeling PK11195 polypharmacology proteasome protein docking protein threading modeling proteomic signature RNA expression regulation SARS-CoV-2 skin aging SNPs sodium-glucose co-transporters 2 Src inhibitors Stone-Wales defects structural bioinformatics structural characterization systems medicine design tuberculosis urinary tract infections uropathogenic bacteria variants virtual screening |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Computational Approaches |
| Record Nr. | UNINA-9910557519403321 |
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Tutone Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Protein Quality Controlling Systems in Plant Responses to Environmental Stresses
| Protein Quality Controlling Systems in Plant Responses to Environmental Stresses |
| Autore | Yule Liu |
| Pubbl/distr/stampa | Frontiers Media SA, 2018 |
| Descrizione fisica | 1 online resource (214 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico | Botany & plant sciences |
| Soggetto non controllato |
autophagy
environmental stress heat shock proteins plant proteasome unfolded protein response |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346745403321 |
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Yule Liu
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| Frontiers Media SA, 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges
| Systemic Autoinflammatory Diseases-Clinical Rheumatic Challenges |
| Autore | Feist Eugen |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (266 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
adult-onset Still's disease
anakinra anti-IL-1 treatment arthritis ASAS classification criteria aspiration autoimmune autoinflammation autoinflammatory disease autoinflammatory diseases autoinflammatory disorder canakinumab CAPS CINCA clinical management colchicine computed tomography (CT) coronavirus cytokines damage index diagnostic delay DNA damage repair dysphagia edema FCAS febuxostat FMF genetic inheritance gout haemophagocytic lymphohistiocytosis hearing loss hepatotoxicity Hounsfield unit human leukocyte antigen IFN-γ IL-1 inhibitors imaging immunoglobulin G4-related orbital disease (IgG4-ROD) inflammation inflammatory idiopathic myopathy Interleukin-1 JAK inhibitor macrophage activation syndrome monogenic autoinflammatory syndrome MWS myositis n/a neoplasms new genetic variant NGS NOMID orbital lymphoma (OL) PBMCs personalized therapy pneumonia proliferation prophylaxis proteasome proteasome-associated autoinflammatory syndrome rheumatoid arthritis SARS-CoV-2 antibody response spondyloarthritis SURF synovitis systemic-onset juvenile idiopathic arthritis T lymphocytes therapy undifferentiated enthesitis and/or arthritis urticarial-like rash γH2AX |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557349503321 |
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Feist Eugen
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and Autophagy
| Ubiquitin and Autophagy |
| Autore | Nazarko Taras Y |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (294 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
aggrephagy
APP ATG12~5/16 complex Atg8 autophagy autophagy initiation autophagy-lysosome pathway BECN1 C. elegans cargo receptors crosstalk Cx43 degradation Dictyostelium endosome ER-phagy FIP200 GABARAP gap junction globoid cell leukodystrophy islet LC3 leukodystrophies lipophagy LIR motif lysophagy lysosome MAPLC3 mitophagy n/a neurodegenerative diseases NFAT5 nucleophagy p62 phagocytosis pinocytosis plants proteasome PSMD14 psychosine retrograde retromer SAR selective autophagy sorting nexins the ubiquitin-proteasome system tissue specificity toll-like receptor 4 TRAF6 trafficking ubiquitin ubiquitin-like protein ubiquitin-proteasome system ubiquitination UBL unfolded protein response UPR UPS xenophagy |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557339503321 |
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Nazarko Taras Y
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System
| Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| Autore | Ashok N. Hegde |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 online resource (241 p.) |
| Collana | Frontiers Research Topics |
| Soggetto topico | Neurosciences |
| Soggetto non controllato |
aging
Alzheimer's disease deubiquitinating glutamate receptors Huntington's disease memory neurodegenerative neuroinflammation proteasome synaptic plasticity |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Ubiquitin and the Brain |
| Record Nr. | UNINA-9910261140803321 |
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Ashok N. Hegde
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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