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Anticancer Inhibitors
| Anticancer Inhibitors |
| Autore | Fantacuzzi Marialuigia |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (216 p.) |
| Soggetto topico |
Research & information: general
Chemistry |
| Soggetto non controllato |
breast cancer
tamoxifen LY294002 synergism apoptosis cell cycle tea (Camellia sinensis) flowers BTFS A2780/CP70 ovarian cancer cells S phase cell cycle arrest nicotinamide phosphoribosyltransferase NAD+ biosynthesis inhibitor azacyclohexane anticancer drug drug design enthalpy effect NSCLC Cathepsin K cell proliferation cell migration cell invasion mTOR isatin-hydrazones cytotoxicity CDK2 inhibitor ATP competitive inhibitor ADME analysis receptor tyrosine kinases protein-protein interactions protein engineering directed evolution angiogenesis binding affinity agonistic activity saponins phytochemicals tea (Camellia sinensis) flower ovarian cancer autophagy ZMYND8 tumorigenesis epigenetic regulation pro-oncogenic effects tumor suppression tacrine-coumarin derivatives DNA topoisomerases I, II lung carcinoma cells A549 chemotherapy prodrug drug targeting overexpressed enzymes ADC ADEPT GDEPT LEAPT PROTAC cyclin-dependent kinase cancer resistance small molecule inhibitors PROTACs statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin fluvastatin atorvastatin pravastatin HMG-CoA reductase inhibitors |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595069203321 |
Fantacuzzi Marialuigia
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondria in Health and Diseases
| Mitochondria in Health and Diseases |
| Autore | Javadov Sabzali |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (434 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
2-oxoglutarate dehydrogenase
4-HNE adenine nucleotide translocase ADP/ATP carrier aging amino acid neurotransmitter ancient mutation antioxidant system antioxidants apoptosis BAX BCL-2 BKCa channels cardiolipin cardiomyocytes cardioprotection cerebellar amino acid metabolism cholangiocellular carcinoma colon complex I (CI) deficiency cyclosporin A cytoskeletal proteins DDE dentate granule cell development dextran DRP1 dsRNA electron and confocal microscopy electron tunneling (ET) energy metabolism epilepsy ERK1/2 ETC complexes fatty acid oxidation ferritin gemfibrozil GW9662 H9c2 cardiomyoblasts healthy cells heart hepatic fibrogenesis hepcidin high-fat diet hippocampus HtrA2/Omi human amniotic membrane human diseases hyperforin hypoglycemia hypoxia inflammation innate immunity inorganic phosphate interferon response intranuclear mitochondria ion homeostasis iron overload ischemia reperfusion injury JNK KmADP Langendorff LHON life span lipid droplet lipid handling liver LONP1 metabolome and proteome profiling mitochondria mitochondria bioenergetics mitochondria calcium buffering mitochondria permeability transition pore mitochondria: energy metabolism mitochondrial cell death mitochondrial connexin 43 mitochondrial dynamics mitochondrial dysfunction mitochondrial function mitochondrial gene expression mitochondrial homeostasis mitochondrial interactions mitochondrial permeability transition pores mitochondrial UCP2 morphology mtDNA mtDNA transcription mtRNA muscle aging myocardial neuron death neuroprotection oxidative phosphorylation oxidative stress perilipin 5 physical performance pilocarpine pioglitazone PKA plectin post-transcriptional mtRNA processing potassium channel pravastatin protein phosphatases pyruvate dehydrogenase pyruvate dehydrogenase kinase reactive oxygen species reactive oxygen species (ROS) reactive oxygen species stress redox state regeneration respirasome assembly respiratory supercomplexes ROS rosiglitazone seizure Siberian population signaling signaling pathways siRNA sodium dichloroacetate specific genetic background telomerase activity telomere length tensile strength transferrin tricarboxylic acid cycle tubulin beta TUNEL TZD uncoupling uncoupling protein ZIP |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557577203321 |
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Javadov Sabzali
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation
| Regional Intestinal Drug Absorption : Biopharmaceutics and Drug Formulation |
| Autore | Gonzalez-Alvarez Maria Isabel |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (238 p.) |
| Soggetto topico |
Manufacturing industries
Medicine and Nursing |
| Soggetto non controllato |
absorption-modifying excipients
BCS class IV drugs BCS drugs bioequivalence biomimetic membrane biopharmaceutics biopharmaceutics classification system Biopharmaceutics Classification System clinical studies colon absorption combined zero- and first-order absorption controlled release drug product DDI disintegration dissolution dissolution test drug absorption drug permeability drug solubility drug solubility/dissolution drug-drug interactions energy intake enteric-coated first-order absorption first-pass effect Franz cell Franz-PAMPA furosemide gastrointestinal gastrointestinal hormone GastroPlus hierarchical support vector regression (HSVR) human colon carcinoma cell layer (Caco-2) ibuprofen ICH in silico modeling in situ perfusion in vitro in vitro in vivo extrapolations intestinal absorption intestinal perfusion intestinal permeability IVIVE location-dependent absorption manometry mechanistic modeling microdevices mucoadhesion nutrient absorption nutrient digestion obesity oral absorption oral drug delivery oral peptide delivery passive drug transport PBBM PBPK permeation enhancers pharmaceutical development pharmacokinetics Phoenix WinNonlin physiologically-based pharmacokinetic (PBPK) modeling postprandial glycaemia pravastatin quality control region of the gut regional intestinal permeability regional/segmental-dependent permeability and absorption route-dependent intestinal metabolism segmental-dependent intestinal permeability segregated flow intestinal model (SFM) shape traditional model (TM) transit compartment absorption model type 2 diabetes zero-order absorption |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Regional Intestinal Drug Absorption |
| Record Nr. | UNINA-9910566462603321 |
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Gonzalez-Alvarez Maria Isabel
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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