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DNA Replication Stress
| DNA Replication Stress |
| Autore | Brosh Jr Robert M |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (368 p.) |
| Soggetto non controllato |
Werner Syndrome
A549 cells epigenetic neurodegeneration Genome integrity adaptation cellular senescence genome instability Werner Syndrome Protein lipofuscin cell cycle checkpoints exonuclease 1 template-switching energy metabolism mutation frequency DNA replication fork regression motor neuron disease Microsatellites Alzheimer's disease chromatin remodeler repair of DNA damage AP site analogue mutagens replication timing Thermococcus eurythermalis nucleolar stress gene expression mutations spectra origin firing Fanconi Anemia superfamily 2 ATPase DNA translocation DNA repair SSB signaling homologous recombination common fragile sites 8-chloro-adenosine replication genome stability mutagenicity fork reversal multiple sclerosis non-B DNA protein stability heterogeneity ubiquitin SenTraGorTM (GL13) replication restart EdU ?-arrestin NER aging SSB end resection oxidative stress ATR dormant origins R loops DNA damage response Difficult-to-Replicate Sequences DNA double-strand repair endonuclease IV ALS double strand break repair premature aging replication stress EXO1 POL? translesion synthesis strand displacements G2-arrest DNA replication pattern SSB repair genome integrity G protein-coupled receptor kinase interacting protein 2 (GIT2) MMR replicative stress senolytics spacer interactome ATR-Chk1 DDR pathway C9orf72 replication fork restart translesion DNA synthesis DNA damage mismatch repair DNA replication stress DNA helicase Polymerase kappa DNA fiber assay H1299 cells TLS APE2 ageing cell death chromosome TopBP1 barley clock proteins post-translational modification 8-oxoG S phase ataxia telangiectasia mutated (ATM) G protein-coupled receptor (GPCR) Polymerase eta cancer G protein-coupled receptor kinase (GRK) helicase genomic instability Parkinson's disease nucleotide excision repair SupF |
| ISBN | 3-03921-390-3 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910367564903321 |
Brosh Jr Robert M
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function
| Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function |
| Autore | Pulido Rafael |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (240 p.) |
| Soggetto non controllato |
hematopoietic cells
DEPArray neuroblastoma liver steatosis MAPK phosphatase DUSP-4 granule neurons neuronal differentiation DUSP10 cytokines MAPKs single cell analysis macrophage asthma E. coli infection MAPK Cpp1 nucleotide receptors atypical DUSP RSV Pmp1 cannabinoids astrocytes sepsis influenza signaling triple-negative breast cancer (TNBC) differentiation HDAC6 (histone deacetylase isoform 6) atypical dual-specificity phosphatases microtubules respiratory viruses MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein) dual-specificity phosphatase Msg5 TLR signaling mitogen-activated protein kinase fungal MKPs macrophages MAP Kinase Phosphatase-2 inflammation Sdp1 circulating tumor cells (CTCs) MAP kinases MAP kinase phosphatases P2X7 proliferation BDNF P2Y13 T cell hypertriglyceridemia integrated omics analysis post-translational modification rhinovirus protein stability ubiquitination dual-specificity phosphatases Mkp-1 cancer brain metastasis HER2 COPD pseudophosphatase |
| ISBN | 3-03921-689-9 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Dual Specificity Phosphatases |
| Record Nr. | UNINA-9910367740903321 |
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Pulido Rafael
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (520 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
intrinsically disordered proteins
epiproteome disordered protein platform molecular recognition feature post-translational modifications physiological homeostasis stress response RIN4 p53 molecular machines intrinsically disordered protein membrane-less organelle neurodegenerative disease p300 HAT acetylation post-translational modification protein aggregation Tau fibrillation intrinsically disorder proteins disorder-to-order regions protein–RNA interactions unstructured proteins conformational plasticity disordered protein folding ribosomal protein spectroscopy protein stability temperature response protein thermostability salt bridges meta strategy dual threshold significance voting decision tree based artificial neural network protein intrinsic disorder intrinsic disorder intrinsic disorder prediction intrinsically disordered region protein conformation transcriptome RNA sequencing Microarray differentially regulated genes gene ontology analysis functional analysis intrinsically disordered structural disorder correlated mutations co-evolution evolutionary couplings residue co-variation interaction surface residue contact network dehydron homodimer hydrogen bond inter-subunit interaction ion pair mutual synergistic folding solvent-accessible surface area stabilization center MLL proteins MLL4 lncRNA HOTAIR MEG3 leukemia histone lysine methyltransferase RNA binding protein hydration wide-line 1H NMR secretion immune extracellular protein-protein interaction structural domain evolution transcription factors DNA-protein interactions Sox2 sequential DNA loading smFRET DNA conformational landscape sequential DNA bending transcription factor dosage oligomer N-terminal prion protein copper binding prion disease mutations Nuclear pore complex FG-Nups phosphorylation coarse-grained CABS model MC simulations statistical force fields protein structure intrinsically disordered proteins (IDPs) neurodegenerative diseases aggregation drugs drug discovery plant virus eIF4E VPg potyvirus molten globule fluorescence anisotropy protein hydrodynamics |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
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Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondrial Transport Proteins
| Mitochondrial Transport Proteins |
| Autore | Palmieri Ferdinando |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (476 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
hypoxia
resistance to hypoxia mitochondria mitochondrial calcium transport mitochondrial calcium uniporter complex mitochondrial Ca2+-induced permeability transition pore cyclophilin D ATP synthase disease error of metabolism mitochondrial carrier mitochondrial carrier disease mitochondrial disease mitochondrial transporter membrane transport mutation SLC25 mitochondrial permeability transition apoptosis necrosis ischemia/reperfusion cancer neurodegeneration cyclosporin A metabolite transport mitochondrial pyruvate carrier sideroflexin TOM TIM chaperones TIM22 protein translocation mitochondrial biogenesis amino acid biological function ion inner mitochondrial membrane mitochondrial carrier family organic acid substrate specificity transport mechanism vitamin USMG5/DAPIT glucose-stimulated insulin secretion glucose-induced expression membrane subunits of ATP synthase ATP synthase oligomers mitochondrial cristae morphology metabolism metabolic disorders adult-onset type II citrullinemia (CTLN2) aspartate/glutamate carrier (AGC) animal model argininosuccinate synthetase (ASS) aversion to carbohydrates citrin food taste neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) protein–protein interaction MPC lifespan pyruvate metabolism mitochondrial transport peroxisomes carrier cofactor ABC transporter aquaporin ion channels potassium channels ATP calcium ROS potassium channel openers MCF function plant metabolism plant development diseases VDAC1 virus pancreatic islets β-cell diabetes glucotoxicity glucolipotoxicity lipotoxicity mitochondrial carriers SLC transporters SLC54 SLC55 LETM SLC56 sequence analysis protein targeting Voltage-Dependent Anion selective Channel isoforms oxidative post-translational modification gene promoter yeast bioenergetics SLC25A1 CIC CTP citrate inflammation 22.q11.2 NAFLD/NASH carnitine carnitine acyl-carnitine carrier carnitine acyl-carnitine translocase post-translational modification solute carrier family 25 SLC25A20 MCU mitochondrial Ca2+ uniporter Ca2+ signaling mitochondrial metabolism skeletal muscle mitochondria SLC25A51 NAD+ transporters NAD electrophysiology ATP-dependent potassium channel |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566465303321 |
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Palmieri Ferdinando
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Modeling and Simulation of Lipid Membranes
| Modeling and Simulation of Lipid Membranes |
| Autore | Marti Jordi |
| Pubbl/distr/stampa | Basel, : MDPI Books, 2022 |
| Descrizione fisica | 1 electronic resource (174 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
peptide
MD GUV LUV azo-amino acid KRas-4B mutation post-translational modification HVR anionic plasma membrane signaling cholesterol model membranes molecular dynamics calorimetry Schiff base imine benzimidazole 2,4-dihydroxybenzaldehyde neutron reflectometry X-ray reflectometry small-angle neutron scattering small-angle X-ray scattering molecular dynamics simulations scattering length density profile phospholipid membrane phosphatidylserine cancer cells MD simulation membrane permeability withaferin A withanone CAPE artepillin C membrane elasticity red blood cells hemodynamics hemorheology microfluidics benzothiadiazine derivatives drug design KCNE3 structural dynamics lipid bilayers molecular dynamics simulation membrane mimetic |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910595071503321 |
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Marti Jordi
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| Basel, : MDPI Books, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Nitric Oxide Signaling in Plants
| Nitric Oxide Signaling in Plants |
| Autore | Hancock John |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (170 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
catalase
monodehydroascorbate reductase tyrosine nitration nitric oxide peroxisome reactive oxygen species S-nitrosation superoxide dismutase antioxidants hydrogen gas hydrogen peroxide hydrogen sulfide S-nitrosothiols S-nitrosoglutathione reductase S-(hydroxymethyl)glutathione nitrate reductase NOFNiR nitrogen metabolism NIA1 NIA2 nitrite nitrate methyl viologen benzyl viologen NO analyzer molybdenum cofactor Arabidopsis thaliana nitro-fatty acids nitroalkenes nitroalkylation electrophile nucleophile signaling mechanism post-translational modification reactive lipid species nitro-lipid-protein adducts Trebouxia microalgae lipid peroxidation diaphorase activity lichens nitric oxide synthase nitrogen dioxide plant growth cell enlargement cell proliferation early flowering PsbO nitric oxide homeostasis cue1/nox1 reactive nitrogen species germination root development stress responses sugar metabolism nitration S-nitrosylation SNO-reductase thiol modification |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557117803321 |
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Hancock John
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases
| Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases |
| Autore | Kwok Hang Fai |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (180 p.) |
| Soggetto topico |
Humanities
Social interaction |
| Soggetto non controllato |
DAPK1
SUMO SENP protein degradation post-translational modification amphibian Bowman-Birk inhibitor Tat peptide molecular cloning antifungal drug design protease inhibitor natural-based compound anticancer therapy lung cancer survivin apoptosis STAT3 colorectal cancer orientin cell cycle arrest Bcl-2 family proteins Astragalus membranaceus insulin PI3K AKT PPARγ PDX-1 Petasites japonicus Asteraceae lignan anti-inflammation NO PGE2 iNOS COX-2 molecular docking peptides kynurenines binding affinity μ-opioid receptor pharmacophore G-protein activation fucoidan PLGA docetaxel drug delivery system anticancer therapy/cancer treatment hIAPP amyloidogenesis insulin granules endoplasmic reticulum anionic lipids F23R variant β-sheet transitions β-cell cytotoxicity unfolded protein response pomegranate punicalagin tannins gingiva fibroblasts antioxidant wound healing branched-chain fatty acids Conidiobolus heterosporus peroxisome proliferator-activated receptor α lipid metabolism fatty acid oxidation hepatocyte |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557607403321 |
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Kwok Hang Fai
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Post-transcriptional Regulation through Long Noncoding RNAs (lncRNAs)
| Post-transcriptional Regulation through Long Noncoding RNAs (lncRNAs) |
| Autore | Ladomery Michael |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (156 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
long non-coding RNA 1
RNA binding protein 2 post-transcriptional regulation long non-coding RNA mRNA stability RNA binding protein microRNA gene expression long noncoding RNA target mimicry alternative splicing protein re-localization translation promotion post-translational modification double-stranded RNA (dsRNA) innate immunity repetitive DNA elements (RE) antisense transcript non-coding RNAs long non-coding RNAs ncRNAs translation cancer lncRNA post-transcription RNA-binding ribonucleoprotein RNAi interactome prediction database CLIP splicing factors miRNAs lncRNAs ceRNAs mTOR pathway |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Post-transcriptional Regulation through Long Noncoding RNAs |
| Record Nr. | UNINA-9910557367803321 |
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Ladomery Michael
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Structure, Activity, and Function of Protein Methyltransferases
| Structure, Activity, and Function of Protein Methyltransferases |
| Autore | Jeltsch Albert |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (292 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
protein lysine methylation
H3K9 methylation PKMT enzyme specificity enzyme regulation heterochromatin protein post-translational modification NSD3 WHSC1L1 structure and function protein arginine methylation PRMT7 epigenetics cancer immunity pluripotency SETDB1 methyltransferase schizophrenia Huntington's disease Rett syndrome Prader-Willi syndrome congenital heart diseases inflammatory bowel disease MLL2 structure H3K4me3 chromatin regulation disease dystonia NSD1 H3K36 SOTOS NUP98-NSD1 AML PRMT6 post-translational modification H3R2me2a SETD3 posttranslational modifications protein histidine methylation actin polymerization cytoskeleton enteroviruses oncogenesis PRMT5 cardiovascular disease neurodegenerative diseases diabetes inflammation G9a GLP EHMT2 EHMT1 post translational modification lysine methylation N-terminal methylation translation eEF1A METTL13 neuron synapse dendritic spine actin cytoskeleton GTPase PRMT1 arginine methylation H4R3 methylation transcriptional regulation cell signaling DNA damage repair PRMT2 SH3 SETMAR Metnase H3K36me2 Hsmar1 non-homologous end joining repair NHEJ transposase transposable elements histone SET7/9 SETD7 lysine-specific methyltransferase (PKMT) cell proliferation stress response post-translational protein modification |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910566479603321 |
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Jeltsch Albert
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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