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ABC Transporters in Human Diseases
| ABC Transporters in Human Diseases |
| Autore | Falguières Thomas |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (494 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
ABC transporters
drug action regulatory extension regulatory insertion mechanism of action MRP1 MRP4 breast cancer proliferation migration invasion cAMP ABCG2 ABCB1 blood-brain barrier PET Alzheimer's disease beta-amyloid tariquidar erlotinib ABCG5 ABCG8 ATP-binding cassette transporter cholesterol polar relay sitosterolemia 5' untranslated region cis-acting elements ABCA subfamily bioinformatics ABC transporter therapy response disease-free survival next-generation sequencing competitive allele-specific PCR P-glycoprotein amyloid-beta neuron SK-N-SH gene therapy AAV PFIC BSEP ABCB11 bile salts intrahepatic cholestasis chaperones PFIC2 BRIC ATP-binding cassette transporter A1 (ABCA1) cholesterol homeostasis reverse cholesterol transport HDL-C dyslipidemia type 2 diabetes microparticles ABCG2 genotype clinico-genetic analysis ethnic specificity genetic variations precision medicine rare variant Roma serum uric acid SUA-lowering therapy urate transporter bile secretion ABCB4 ABCC2 ABCG5/G8 molecular partners phytosterol xenosterol atherosclerosis gall stone ABC transporter ABC (ATP-binding cassette) transporters multidrug resistance transport trafficking urate mutations polymorphisms ABCC6 TNAP NT5E Pseudoxanthoma elasticum (PXE) cancer membrane protein functional divergence calcification pseudoxanthoma elasticum generalized arterial calcification of infancy pyrophosphate therapies ABCA7 phagocytosis Aβ peptides yeast multidrug transporter anticancer antifungal resistance mechanism peroxisome adrenoleukodystrophy fatty acids gout early-onset gout hyperuricemia uric acid BCRP single nucleotide polymorphism SNP homology modeling substrate-binding site cellular ATP efflux mutagenesis intracellular traffic MDR3 phosphatidylcholine RAB GTPase taxol drug transport |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910674029103321 |
Falguières Thomas
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Adaptive diversification [[electronic resource] /] / Michael Doebeli
| Adaptive diversification [[electronic resource] /] / Michael Doebeli |
| Autore | Doebeli Michael <1961-> |
| Edizione | [Course Book] |
| Pubbl/distr/stampa | Princeton, N.J., : Princeton University Press, 2011 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 578.4 |
| Collana | Monographs in population biology |
| Soggetto topico |
Adaptation (Biology) - Mathematical models
Biodiversity - Mathematical models Evolution (Biology) - Mathematical models |
| Soggetto genere / forma | Electronic books. |
| Soggetto non controllato |
LotkaЖolterra models
Maynard Smith model Richard Lenski adaptive diversification adaptive dynamics theory adaptive dynamics adaptive speciation anisogamy asexual speciation assortative mating biological diversity clonal models coevolution coevolutionary dynamics conformist cultures cooperative interactions crossfeeding cultural evolution dispersal rates disruptive selection diverging phenotypic clusters diversification ecological character displacement ecological dynamics ecology ecosystem evolutionary biology evolutionary branching evolutionary dynamics evolutionary processes evolutionary trajectory experimental evolution frequency dependence frequency independence frequency-dependent competition frequency-dependent interactions frequency-dependent selection gamete size individual-based models intraspecific cooperation language memes language mainstream culture mathematical modeling mating populations microbes mutualism mutualistic interactions niche ecology partial differential equation models pattern formation phenotype distributions phenotype phenotypic differentiation phenotypic divergence polymorphic populations polymorphism polymorphisms predation predatorаrey interactions prezygotic reproductive isolation religion religious diversification reproductive isolation resource competition sexual populations sexual reproduction speciation model trophic preference |
| ISBN |
1-283-15248-7
9786613152480 1-4008-3893-2 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front matter -- Contents -- Acknowledgments -- CHAPTER ONE. Introduction -- CHAPTER TWO. Evolutionary Branching in a Classical Model for Sympatric Speciation -- CHAPTER THREE. Adaptive Diversification Due to Resource Competition in Asexual Models -- CHAPTER FOUR. Adaptive Diversification Due to Resource Competition in Sexual Models -- CHAPTER FIVE. Adaptive Diversification Due to Predator-Prey Interactions -- CHAPTER SIX. Adaptive Diversification Due to Cooperative Interactions -- CHAPTER SEVEN. More Examples: Adaptive Diversification in Dispersal Rates, the Evolution of Anisogamy, and the Evolution of Trophic Preference -- CHAPTER EIGHT. Cultural Evolution: Adaptive Diversification in Language and Religion -- CHAPTER NINE. Adaptive Diversification and Speciation as Pattern Formation in Partial Differential Equation Models -- CHAPTER TEN. Experimental Evolution of Adaptive Diversification in Microbes -- APPENDIX. Basic Concepts in Adaptive Dynamics -- Bibliography -- Index |
| Record Nr. | UNINA-9910456402603321 |
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Doebeli Michael <1961->
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| Princeton, N.J., : Princeton University Press, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Adaptive diversification [[electronic resource] /] / Michael Doebeli
| Adaptive diversification [[electronic resource] /] / Michael Doebeli |
| Autore | Doebeli Michael <1961-> |
| Edizione | [Course Book] |
| Pubbl/distr/stampa | Princeton, N.J., : Princeton University Press, 2011 |
| Descrizione fisica | 1 online resource (346 p.) |
| Disciplina | 578.4 |
| Collana | Monographs in population biology |
| Soggetto topico |
Adaptation (Biology) - Mathematical models
Biodiversity - Mathematical models Evolution (Biology) - Mathematical models |
| Soggetto non controllato |
LotkaЖolterra models
Maynard Smith model Richard Lenski adaptive diversification adaptive dynamics theory adaptive dynamics adaptive speciation anisogamy asexual speciation assortative mating biological diversity clonal models coevolution coevolutionary dynamics conformist cultures cooperative interactions crossfeeding cultural evolution dispersal rates disruptive selection diverging phenotypic clusters diversification ecological character displacement ecological dynamics ecology ecosystem evolutionary biology evolutionary branching evolutionary dynamics evolutionary processes evolutionary trajectory experimental evolution frequency dependence frequency independence frequency-dependent competition frequency-dependent interactions frequency-dependent selection gamete size individual-based models intraspecific cooperation language memes language mainstream culture mathematical modeling mating populations microbes mutualism mutualistic interactions niche ecology partial differential equation models pattern formation phenotype distributions phenotype phenotypic differentiation phenotypic divergence polymorphic populations polymorphism polymorphisms predation predatorаrey interactions prezygotic reproductive isolation religion religious diversification reproductive isolation resource competition sexual populations sexual reproduction speciation model trophic preference |
| ISBN |
1-283-15248-7
9786613152480 1-4008-3893-2 |
| Classificazione | SCI088000SCI020000SCI027000 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Front matter -- Contents -- Acknowledgments -- CHAPTER ONE. Introduction -- CHAPTER TWO. Evolutionary Branching in a Classical Model for Sympatric Speciation -- CHAPTER THREE. Adaptive Diversification Due to Resource Competition in Asexual Models -- CHAPTER FOUR. Adaptive Diversification Due to Resource Competition in Sexual Models -- CHAPTER FIVE. Adaptive Diversification Due to Predator-Prey Interactions -- CHAPTER SIX. Adaptive Diversification Due to Cooperative Interactions -- CHAPTER SEVEN. More Examples: Adaptive Diversification in Dispersal Rates, the Evolution of Anisogamy, and the Evolution of Trophic Preference -- CHAPTER EIGHT. Cultural Evolution: Adaptive Diversification in Language and Religion -- CHAPTER NINE. Adaptive Diversification and Speciation as Pattern Formation in Partial Differential Equation Models -- CHAPTER TEN. Experimental Evolution of Adaptive Diversification in Microbes -- APPENDIX. Basic Concepts in Adaptive Dynamics -- Bibliography -- Index |
| Record Nr. | UNINA-9910781692503321 |
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Doebeli Michael <1961->
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| Princeton, N.J., : Princeton University Press, 2011 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Biochemical Biomarkers and Neurodegenerative Diseases
| Biochemical Biomarkers and Neurodegenerative Diseases |
| Autore | Ciaccio Marcello |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (156 p.) |
| Soggetto topico |
Medicine
Neurosciences |
| Soggetto non controllato |
GLUT3
cerebral ischemia MCAO resveratrol astrocytes AMPK amyotrophic lateral sclerosis GSK3β neurodegenerative disease PD Arylsulfatase A lysosomes GWAS Gaucher's disease prognostic biomarker focused ultrasound MR-guided focused ultrasound high-intensity focused ultrasound ablation magnetic resonance imaging image quality stereotaxic techniques essential tremor Alzheimer's disease amyloid precursor protein Tyr682 residue YENPTY motif Fyn tyrosine kinase amyloid beta ALS biomarker beta amyloid AD biomarkers SARS-CoV-2 neuroinflammation neurodegenerative nisease nervous system Alzheimer's Disease Vitamin D 25(OH)D levels Vitamin D deficiency inherited neuromuscular disorders rare diseases multiple sclerosis genetic polymorphisms FOXP3 GATA3 vitamin D neuromelanin nigrosome-1 iron radiomics neurodegenerative diseases Parkinson's disease parkinsonian disorders |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557361103321 |
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Ciaccio Marcello
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
| Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0 |
| Autore | Dansette Patrick M |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (286 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
Antibiotics
Bacillus biosynthetic gene clusters comparative analysis cytochrome P450 monooxygenase Mycobacterium P450 diversity percentage P450 profiling secondary metabolites NADPH-cytochrome P450 reductase (CPR) microsomal cytochrome P450 (CYP) Cytochrome b5 (CYB5) protein dynamics electron-transfer (ET) protein–protein interaction cytochromes P450 CYP3A4 active site access channels cavities boundaries minimal cost paths CYP139A1 genome data mining host metabolism Mycobacterium tuberculosis polyketides tuberculosis cryptococcus cryptococcus neoformans CYP51 fungal pathogens genome data-mining human pathogens CYP diversity analysis tremellomycetes trichosporon mechanism-based inhibitor crystal structure CYP4 genes genetic polymorphisms 20-HETE fatty acid arachidonic acid SNPs molecular functionality metabolism lamellar ichthyosis Bietti’s crystalline dystrophy cytochrome P450 isoform membrane protein protein-membrane interactions enzyme substrate specificity mutagenesis molecular dynamics simulation Sogatella furcifera sulfoxaflor transcriptome RNA interference CYP2C8 polymorphisms reactive oxygen species paclitaxel cytochrome P450 reductase electron transfer extracellular vesicles exosomes extrahepatic tissues plasma circulatory CYPs CYP450 drug metabolism precision Cardio-Oncology precision medicine systems medicine cytochromes P450 monooxygenases Cyanobacteria gene-cluster diversity percentage mathematical formula phylogenetic analysis Streptomyces cytochrome P450 monooxygenases terpenes P450 blooming non-ribosomal peptides cytochrome P450 monooxygenenases CYP128A1 Mycobacterium tuberculosis H37Rv molecular dynamic simulations azole drugs menaquinone |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Cytochromes P450 |
| Record Nr. | UNINA-9910557761103321 |
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Dansette Patrick M
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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HLA-G-mediated Immune Tolerance: Past and New Outlooks
| HLA-G-mediated Immune Tolerance: Past and New Outlooks |
| Autore | Silvia Gregori |
| Pubbl/distr/stampa | Frontiers Media SA, 2017 |
| Descrizione fisica | 1 electronic resource (92 p.) |
| Collana | Frontiers Research Topics |
| Soggetto non controllato |
Pregnancy
Autoimmunity Immuno-modulation Pre-Eclampsia Infections Exosomes HLA-G polymorphisms tolerance Cancer |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | HLA-G-mediated Immune Tolerance |
| Record Nr. | UNINA-9910220053103321 |
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Silvia Gregori
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| Frontiers Media SA, 2017 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Odyssey of Surfactant Proteins SP-A and SP-D: Innate Immune Surveillance Molecules
| Odyssey of Surfactant Proteins SP-A and SP-D: Innate Immune Surveillance Molecules |
| Autore | Kishore Uday |
| Pubbl/distr/stampa | Frontiers Media SA, 2020 |
| Descrizione fisica | 1 electronic resource (205 p.) |
| Soggetto topico |
Medicine
Immunology |
| Soggetto non controllato |
SP-A
SP-D inflammation cancer innate immunity infection polymorphisms |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Odyssey of Surfactant Proteins SP-A and SP-D |
| Record Nr. | UNINA-9910557219903321 |
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Kishore Uday
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| Frontiers Media SA, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Pharmacogenomics : From Basic Research to Clinical Implementation
| Pharmacogenomics : From Basic Research to Clinical Implementation |
| Autore | Scheinfeldt Laura B |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (162 p.) |
| Soggetto topico |
Medicine
Pharmacology |
| Soggetto non controllato |
pharmacogenomics
return of results genetic counseling qualitative pharmacogenetics implementation pharmacogenetics service screening pre-emptive personalized medicine precision medicine community pharmacy pharmacogenomic testing genetic privacy pharmaco-economics polymorphisms pharmacogenes pharmacogenomic machine learning adaptation human evolution US Food and Drug Administration clinical actionability clinical translation chronic kidney disease CYP3A5 polymorphism progression pharmacogenomics (PGx) pediatrics best practice alerts (BPAs) electronic health records (EHR) genomic indicators clinical decision support (CDS) phenotype genotype polypharmacy chronic disease medication management electronic medical record artificial intelligence |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Pharmacogenomics |
| Record Nr. | UNINA-9910566459103321 |
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Scheinfeldt Laura B
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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