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Advances and Novel Treatment Options in Metastatic Melanoma
| Advances and Novel Treatment Options in Metastatic Melanoma |
| Autore | Facchiano Antonio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 online resource (528 p.) |
| Soggetto topico | Medicine and Nursing |
| Soggetto non controllato |
ABT-737
acetazolamide acetylcholine adjuvant therapy amoeboid motility angiogenesis apoptosis arthralgia Bcl-2 family BCL2L10 biomarkers BRAF BRAF inhibitor BRAF inhibitors BRAF-mutant melanoma cancer cancer associated fibroblast cancer stem cells carbonic anhydrase cell therapy checkpoint inhibitor cholinergic system combined therapy ctDNA CXCL10 cyclopamine cytokines cytotoxicity diagnosis DOCK4 drug resistance essential oils exosomes extracellular vesicles FAK hedgehog HIPPO HuR immunity immunotherapy interferon invasion ipilimumab lactate dehydrogenase lipid metabolism liquid biopsy liver-directed-therapies machine learning MANS peptide MARCKS mechanism of action melanoma melanoma immune infiltrate melanoma markers melanoma metastasis melanoma PDX melanomagenesis metalloproteinases metastases metastasis metastatic dormancy metastatic therapy metastatic uveal melanoma (mUM) microenvironment microRNAs MITF ML258 motility mucosal melanoma muscarinic receptors n/a nanoparticles nicotinic receptors nivolumab OXPHOS patient stratification PD-1 pembrolizumab phosphorylation plasmacytoid dendritic cells prediction principal component analysis prognosis prognostication protein tyrosine phosphatase PTPs inhibitors Rac1 radiotherapy resistance rheumatoid arthritis sex-hormones sex/gender ShcD adaptor protein siRNA slow cycling phenotype small molecules SOCE STAT3 Support Vector Machine survival target therapy targeted therapy targeted-therapy therapeutic resistance therapy TLR TPC2 tumor microenvironment tumour microenvironment uveal melanoma (UM) WNT5A |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557612103321 |
Facchiano Antonio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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AMP-Activated Protein Kinase Signalling
| AMP-Activated Protein Kinase Signalling |
| Autore | Neumann Dietbert |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (452 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
?-linker
?RIM 2-methoxyestradiol 3T3-L1 A769662 acetyl-CoA activation loop adaptive thermogenesis adenosine monophosphate-activated protein kinase adherent junctions adipocyte adipose tissue AICAR AID Akt AML AMP-activated protein kinase AMP-activated protein kinase (AMPK) AMPK AMPK kinase AS160 assisted reproduction techniques atrophy autophagy beiging CaMKK2 carrier catechol-O-methyltransferase CBS cellular energy sensing chromatin remodeling CML CMML co-expression CREB developmental origins of health and disease (DOHaD) dietary fatty acids differentiation DNA methylation endothelial cells endothelial function endothelial nitric-oxide synthase energy deficiency energy metabolism energy utilization epigenetics epithelial cells exercise fatty acid oxidation fiber-type food intake gestational diabetes mellitus glucose uptake glycogen glycogen storage disease HDAC4/5 HDACs heat shock protein hepatocyte hindlimb suspension histone modification host defense hypertension hypertrophy hypothalamus IL-1? Immediate early genes indirect calorimetry infection insulin signalling ionomycin KATs kidney disease lipid metabolism liver LKB1 macrophages MDCK MDS mechanical unloading medulloblastoma membrane membranes metabolic disease metabolic-inflammation metabolism microarrays mitochondria monocytes motility motor endplate remodeling mTOR mycobacteria MyHC I(?) n/a NAD+ nectin-afadin NLRP3 nutrient-sensing signals nutrigenomics nutrition oxidative stress p70S6K par complex peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) phenylephrine phosphorylation PKA preeclampsia pregnancy proteasome protein acetylation protein kinase B protein synthesis pump regrowth renin-angiotensin system resveratrol signaling sirtuin 1 (SIRT1) skeletal muscle soleus muscle soluble Adenylyl cyclase sonic hedgehog spermatozoa steatosis stress synaptic activation TAK1 TBC1D4 tight junctions transcription transporter ULK vasoconstriction vasodilation ZO-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346858503321 |
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Neumann Dietbert
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Benefits of Resveratrol Supplementation / María P. Portillo, Alfredo Fernandez-Quintela
| Benefits of Resveratrol Supplementation / María P. Portillo, Alfredo Fernandez-Quintela |
| Autore | Portillo María P |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 electronic resource (260 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
polyphenols
?-viniferin leptin resistance p53 kidney energy restriction grape powder extract cytokines phosphorylation obesity energy metabolism metabolic pathways endothelial function polyol pathway antioxidant caloric restriction rat adipose tissue microparticles pathways angiotensin converting enzyme 2 resistance esRAGE interleukins metabolic syndrome dissolution rate thermogenesis streptozotocin bioavailability solubility metabolism renin-angiotensin system microbiota Sirt-1 magnesium dihydroxide hypertrophy metabolic diseases physiological adaption red wine extract lens distribution MTA1 sirtuin inflammation cardiac function rats cisplatin resveratrol mitochondria breast cancer ischemia-reperfusion cardiovascular metabolites gut microbiota prostate cancer performance type 2 diabetes cafeteria diet high-fat high-sucrose diet resistance exercise aging diabetes oxidative stress |
| ISBN |
9783039212767
3039212761 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910346854603321 |
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Portillo María P
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Characterization and Clinical Management of Dilated Cardiomyopathy
| Characterization and Clinical Management of Dilated Cardiomyopathy |
| Autore | Merlo Marco |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (232 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
alternative splicing
arrhythmias arrhythmic risk stratification atrial fibrillation biomarkers calcium cardiac channelopathy cardiac magnetic resonance cardiac magnetic resonance imaging cardiac resynchronization therapy cardiac sodium channel cardiomyopathy congenital heart disease congestive heart failure desmin diastolic dysfunction dilated cardiomyopathy DNA methylation duchenne muscular distrophy epigenetics gene therapy genetics heart heart failure laminopathy late gadolinium enhancement left atrial strain left ventricle non-compaction cardiomyopathy left ventricle sphericity index left ventricular noncompaction left ventricular reverse remodelling LMNA long axis strain long-term outcomes major adverse cardiovascular events malignant ventricular arrhythmia mammalian target of rapamycin (mTOR) complex-1 mdx membrane stabilization mitochondrial dysfunction muscular dystrophy myopathy n/a non-ischemic cardiomyopathy non-sense mRNA decay nonischemic dilated cardiomyopathy NT-proBNP oxidative stress phospholamban phosphorylation precision medicine RNA binding motif protein 20 (RBM20) sarcomere SCN5A Serca2a sex differences supraventricular arrhythmia systolic dysfunction tachycardiomyopathy titin troponin T ventricular arrhythmia whole exome sequencing |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557595503321 |
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Merlo Marco
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Disease and the Hippo Pathway: Cellular and Molecular Mechanisms
| Disease and the Hippo Pathway: Cellular and Molecular Mechanisms |
| Autore | Hansen Carsten Gram |
| Pubbl/distr/stampa | MDPI - Multidisciplinary Digital Publishing Institute, 2019 |
| Descrizione fisica | 1 online resource (226 p.) |
| Soggetto topico | Biology, life sciences |
| Soggetto non controllato |
adaptive immunity
angiogenesis anti-cancer therapy autoimmunity cancer cancer immunity castration resistance chromatin ECM EMT epigenetic feedback loops fibroblasts fibrosis G protein-coupled receptor GPCR Hippo hippo pathway Hippo pathway Hippo signalling innate immunity LATS LATS (large tumor suppressor kinase) LATS1/2 Lats2 Mps one binder MST MST (mammalian STE20-like protein kinase) MST1/2 myofibroblast n/a NDR peripheral nerve sheath tumor phosphorylation prostate cancer protein kinase protein-protein interactions schwannoma signal cross-talk signal transduction skin cancer skin development stem cell stem cells STK38 STRIPAK structure biology Taz TAZ TAZ (transcriptional co-activator with PDZ-binding motif) TEAD transcription tumorigenesis vascular mimicry wound healing Yap YAP YAP (yes-associated protein) YAP/TAZ zebrafish |
| ISBN | 3-03921-777-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Disease and the Hippo Pathway |
| Record Nr. | UNINA-9910367742003321 |
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Hansen Carsten Gram
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| MDPI - Multidisciplinary Digital Publishing Institute, 2019 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor
| Fibroblast Growth Factor Receptor (FGFR) Signaling Pathway in Tumor |
| Autore | Holzmann Klaus |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (276 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
adenocarcinoma of the esophagogastric junction
AKT anticancer astrocytoma autocrine signaling autophagy brain cancer breast cancer cancer cancer signaling cancer-associated fibroblasts coreceptor ERK ERK1/2 estrogen FGF FGF-mediated signaling FGF18 FGF19 FGF2 FGF8 FGFR FGFR1 FGFR2 FGFR2c FGFR4 fibroblast growth factor fibroblast growth factor receptors FRS2 gastric cancer gene regulation GPER HCC HEK293 immunohistochemistry infigratinib sensitivity inhibitors JNK1 keratinocyte kinase inhibitor LY2874455 malignant glioma malignant pleural mesothelioma melanoma membrane proteins monoclonal antibody MTOR n/a negative feedback loop neoadjuvant therapy neurite outgrowth NVP-BGJ398 optogenetics overall survival PC12 phosphorylation prognosis receptor cross-talk receptor kinase resistance review sarcoma seborrheic keratosis serine signaling skin small molecule Sprouty proteins squamous and basal cell carcinoma structure targeted therapy tumor promoter tumor suppressor |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Fibroblast Growth Factor Receptor |
| Record Nr. | UNINA-9910557898903321 |
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Holzmann Klaus
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Functionally Relevant Macromolecular Interactions of Disordered Proteins
| Functionally Relevant Macromolecular Interactions of Disordered Proteins |
| Autore | Simon Istvan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 online resource (520 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
aggregation
CABS model co-evolution coarse-grained conformational plasticity copper binding correlated mutations decision tree based artificial neural network dehydron differentially regulated genes disorder-to-order regions disordered protein disordered protein platform DNA conformational landscape DNA-protein interactions drug discovery drugs dual threshold eIF4E epiproteome evolution evolutionary couplings extracellular FG-Nups fluorescence anisotropy folding functional analysis gene ontology analysis histone lysine methyltransferase homodimer HOTAIR hydration hydrogen bond immune inter-subunit interaction interaction surface intrinsic disorder intrinsic disorder prediction intrinsically disorder proteins intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered proteins (IDPs) intrinsically disordered region ion pair leukemia lncRNA MC simulations MEG3 membrane-less organelle meta strategy Microarray MLL proteins MLL4 molecular machines molecular recognition feature molten globule mutual synergistic folding N-terminal prion protein neurodegenerative disease neurodegenerative diseases Nuclear pore complex oligomer p300 HAT acetylation p53 phosphorylation physiological homeostasis plant virus post-translational modification post-translational modifications potyvirus prion disease mutations protein protein aggregation protein conformation protein hydrodynamics protein intrinsic disorder protein stability protein structure protein thermostability protein-protein interaction protein-RNA interactions residue co-variation residue contact network ribosomal protein RIN4 RNA binding RNA sequencing salt bridges secretion sequential DNA bending significance voting smFRET solvent-accessible surface area Sox2 sequential DNA loading spectroscopy stabilization center statistical force fields stress response structural disorder structural domain Tau fibrillation temperature response transcription factor dosage transcription factors transcriptome unstructured proteins VPg wide-line 1H NMR |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557509403321 |
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Simon Istvan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Information Theory in Molecular Evolution: From Models to Structures and Dynamics
| Information Theory in Molecular Evolution: From Models to Structures and Dynamics |
| Autore | Morcos Faruck |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (135 p.) |
| Soggetto topico |
Biology, life sciences
Research and information: general |
| Soggetto non controllato |
allostery
bacterial signaling Brownian process catalytic mechanism chaos co-evolution coevolutionary analysis conformational changes contact prediction cumulative sum DD-transpeptidase direct coupling analysis direct-coupling analysis elastic network model entropy epistasis evolution evolutionary coupling analysis fitness landscape interaction specificity Kolmogorov complexity maximum entropy models monofractal mutational phenotypes n/a non-linear PBP-A phosphorylation phylogenetic bias phylogeny power law protein conformational dynamics protein contact predictions protein engineering sequence analysis sequence reweighting specificity determining contacts statistical inference TEM-1 TOHO-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Altri titoli varianti | Information Theory in Molecular Evolution |
| Record Nr. | UNINA-9910557351503321 |
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Morcos Faruck
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Insulin-Like Growth Factors in Development, Cancers and Aging
| Insulin-Like Growth Factors in Development, Cancers and Aging |
| Autore | Werner Haim |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (196 p.) |
| Soggetto topico |
Biology, life sciences
Research & information: general |
| Soggetto non controllato |
age-related disease
aging agonists anti-metastatic anti-tumor atrophy autophagy cachexia cognitive impairment diabetes functional RTK/GPCR hybrid G-proteins glucose regulated protein (GRP) 94 GPCRs growth hormone health-span hybrids hypertrophy IGF system IGF-1 IGF-1R IGF-I IGF-I receptor IGF-II IGF-IR IGF-Trap IGFBP IGFBP-1 IGFBP-3 IGFBP-3R insulin insulin receptor insulin-like growth factor insulin-like growth factor-1 IR-A IRs longevity longitudinal study mAb therapy mitochondria mouse models MSCs muscle regeneration myogenesis n/a nuclear translocation obligate chaperone older adults oxidative stress phosphorylation receptor activation senescence signaling skeletal muscle structural studies targeted therapeutics TMEM219 tyrosine kinase receptor β-arrestins |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557735703321 |
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Werner Haim
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Intrinsically Disordered Proteins and Chronic Diseases
| Intrinsically Disordered Proteins and Chronic Diseases |
| Autore | Kulkarni Prakash |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 online resource (224 p.) |
| Soggetto topico | Research & information: general |
| Soggetto non controllato |
binding mechanism
coactivators conformational ensemble conformational plasticity COR15A depletion interaction diffusion disease-related proteins drug design dynamic configuration electrostatics entropic force extremely fuzzy complex free energy landscape functional segments fuzzy interactions gene regulation glucocorticoid receptor IDP intrinsic disordered protein intrinsically disordered intrinsically disordered protein intrinsically disordered proteins intrinsically disordered regions Kinase-inducible domain interacting domain kinetics Late embryogenesis abundant liquid-liquid phase separation low-complexity sequences membraneless organelles microtubule associated protein microtubules molecular dynamics molecular modelling mouse double minute 2 mouse double minute 4 n/a nuclear magnetic resonance Nuclear magnetic resonance optical tweezer order-disorder transition PAGE4 phosphomimetics phosphorylation protein complementation assays protein diffusion protein interaction protein structure prediction protein-protein interaction replica exchange molecular dynamics split-GFP reassembly subcellular location tau tau-microtubule association transactivation activity transient secondary structure Trifluoroethanol tumor protein p53 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557746903321 |
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Kulkarni Prakash
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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