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Impaired Mitochondrial Bioenergetics under Pathological Conditions
| Impaired Mitochondrial Bioenergetics under Pathological Conditions |
| Autore | Lenaz Giorgio |
| Pubbl/distr/stampa | Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 |
| Descrizione fisica | 1 electronic resource (460 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences Biochemistry |
| Soggetto non controllato |
aging heart
Bcl-2 family mitochondria programmed cell death fatty acid oxidation palmitate oleate m.3243A> G mutation MT-ATP6 m.8909T> C ATP synthase nephropathy oxidative phosphorylation mitochondrial disease cardiolipin Barth syndrome Sengers syndrome respiratory chain Dilated Cardiomyopathy with Ataxia cardiomyopathy mammalian complex I NADH dehydrogenase complex I assembly complex I structure complex I deficiency supernumerary subunits electron transport chain mitochondrial dysfunction Leigh syndrome mitochondrial diseases yeast Saccharomyces cerevisiae pet mutants pancreatic endocrine cells mathematical model cellular bioenergetics diabetes glucagon insulin exercise immune system metabolic disease COVID-19 mitochondrial dynamics viral infections MAVS RIG-I MDA5 innate immune response SARS CoV-2 RSV influenza respiratory supercomplexes ROS ATP synthase/hydrolase mitochondrial permeability transition pore cristae cellular signaling human disease mitochondrial dynamic cell signaling cancer respiratory complexes oxidative stress mitochondrial DNA MTCYB mutations cytochrome b complex III aging energy metabolism entorhinal cortex lipoxidation-derived damage neurodegeneration oxidative damage protein import respiratory complex assembly supercomplexes mitochondrial proteostasis heart failure bioenergetics assembly factor atypical myopathy high-resolution respirometry toxicity assays cell culture equine primary myoblasts fibroblasts frozen tissue leukocytes oxygen consumption platelets respirometry skeletal muscle |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910585934503321 |
Lenaz Giorgio
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| Basel, : MDPI - Multidisciplinary Digital Publishing Institute, 2022 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Mitochondria in Health and Diseases
| Mitochondria in Health and Diseases |
| Autore | Javadov Sabzali |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (434 p.) |
| Soggetto topico | Medicine |
| Soggetto non controllato |
hypoglycemia
sodium dichloroacetate pyruvate dehydrogenase kinase pyruvate dehydrogenase oxidative stress neuron death cholangiocellular carcinoma mitochondria energy metabolism oxidative phosphorylation 4-HNE DRP1 ERK1/2 hippocampus JNK mitochondrial dynamics PKA protein phosphatases TUNEL DDE high-fat diet mitochondrial UCP2 ROS antioxidant system uncoupling protein mitochondria: energy metabolism lipid handling fatty acid oxidation potassium channel reactive oxygen species antioxidants life span aging BKCa channels pravastatin gemfibrozil liver colon mitochondrial function cyclosporin A mitochondria calcium buffering mitochondria bioenergetics mitochondria permeability transition pore inorganic phosphate hepatic fibrogenesis HtrA2/Omi reactive oxygen species stress mitochondrial homeostasis complex I (CI) deficiency metabolome and proteome profiling reactive oxygen species (ROS) respirasome assembly electron tunneling (ET) perilipin 5 lipid droplet H9c2 cardiomyoblasts adenine nucleotide translocase respiratory supercomplexes ETC complexes dentate granule cell epilepsy hyperforin LONP1 neuroprotection pilocarpine seizure siRNA cardioprotection mitochondrial permeability transition pores mitochondrial connexin 43 cardiolipin iron overload hepcidin transferrin ferritin ZIP inflammation mtDNA mitochondrial dysfunction muscle aging physical performance LHON Siberian population ancient mutation specific genetic background apoptosis human amniotic membrane mitochondrial cell death BAX BCL-2 tensile strength mitochondrial gene expression mtDNA transcription mtRNA post-transcriptional mtRNA processing dsRNA innate immunity interferon response amino acid neurotransmitter cerebellar amino acid metabolism hypoxia 2-oxoglutarate dehydrogenase tricarboxylic acid cycle heart cytoskeletal proteins mitochondrial interactions plectin tubulin beta signaling GW9662 ischemia reperfusion injury Langendorff myocardial pioglitazone redox state rosiglitazone TZD uncoupling ADP/ATP carrier KmADP dextran morphology cardiomyocytes telomere length telomerase activity development regeneration intranuclear mitochondria healthy cells electron and confocal microscopy signaling pathways ion homeostasis human diseases |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557577203321 |
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Javadov Sabzali
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Regulation of Central Carbon and Amino Acid Metabolism in Plants
| Regulation of Central Carbon and Amino Acid Metabolism in Plants |
| Autore | Timm Stefan |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 |
| Descrizione fisica | 1 electronic resource (182 p.) |
| Soggetto topico |
Research & information: general
Technology: general issues |
| Soggetto non controllato |
Arabidopsis
abiotic stress response photosynthesis phosphoglycolate phosphatase photorespiration 2-phosphoglycolate Arabidopsis thaliana glycolate oxidase protein phosphorylation Zea mays Portulaca grandiflora C4 photosynthesis Crassulacean acid metabolism (CAM), evolution development PEP carboxylase Portulacaceae glycine decarboxylase metabolite signaling/acclimation TCA cycle Calvin-Benson cycle photoperiodic changes redox-regulation environmental adaptation Glycolate oxidase evolution Archaeplastida Cyanobacteria MCF oxidative phosphorylation mitochondrial carriers transporters energy balancing cyclic electron flux malate valve C3 cycle acclimation chlorophyll a fluorescence fluctuating light natural variation pyruvate kinase glycolysis respiratory metabolism |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557355703321 |
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Timm Stefan
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2021 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Tuberculosis Drug Discovery and Development 2019
| Tuberculosis Drug Discovery and Development 2019 |
| Autore | Riccardi Giovanna |
| Pubbl/distr/stampa | Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 |
| Descrizione fisica | 1 electronic resource (296 p.) |
| Soggetto topico |
Research & information: general
Biology, life sciences |
| Soggetto non controllato |
mycobacteria
tuberculosis multi-drug resistance drug discovery promiscuous targets Mycobacterium tuberculosis rifampin isoniazid mechanisms of resistance mutations granulomas caseum cell envelope dormancy delpazolid macozinone DprE1 inhibitor clinical studies discovery mode of action drug resistance toxicity target energy metabolism electron transport chain oxidative phosphorylation bedaquiline Q203 MID3 pharmacokinetics pharmacodynamics drug-drug interactions in vitro in vivo drug development tuberculosis treatment biomarkers drug combination clinical trial BCG tuberculosis vaccines TBVI EDCTP IAVI CTVD host-directed therapy anti-virulence compounds TB post-treatment sequelae surgery pulmonary rehabilitation Carlo Forlanini artificial pneumothorax structure-based drug design target-based drug design PknB PknG DNA gyrase antibiotic mycobacterium genomics transcriptomics proteomics metabolomics lipidomics target identification mechanism of action antimicrobial drug resistance (AMR) target-based screening phenotypic screening antituberculosis agents antimycobacterial anti-TB drug pipeline privileged targets lead generation |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Record Nr. | UNINA-9910557627203321 |
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Riccardi Giovanna
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| Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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